Determining the optimal daily gonadotropin dose to maximize the oocyte yield in elective egg freezing cycles.

IF 4.2 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Reproductive Biology and Endocrinology Pub Date : 2024-06-06 DOI:10.1186/s12958-024-01236-4
Raoul Orvieto, Anouk Savir Kadmon, Nira Morag, Aliza Segev-Zahav, Ravit Nahum
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Abstract

Objective: Ovarian stimulation (OS) with high daily gonadotropin doses are commonly offered to patients attempting social/elective egg freezing. However, the optimal daily gonadotropin dose that would allow a higher oocyte yield in the successive IVF cycle attempt was not settled and should be determined.

Patients and methods: Data from all women admitted to our IVF unit for social/EEF, who underwent two consecutive IVF cycle attempts, with only those who used in the first attempt a starting daily gonadotropin dose of 300IU were analyzed. Patients characteristics and OS variables were used in an attempt to build a logistic model, helping in determining the daily gonadotropin dose that should be offered to patient during their second EEF attempt, aiming to further increase their oocyte yield.

Results: Three hundred and thirteen consecutive women undergoing two successive IVF cycle attempts were evaluated. Using logistic regression model, two equations were developed using individual patient-level data that determine the daily gonadotropin dose needed aiming to increase the oocyte yield in the successive cycle. (a): X=-0.514 + 2.87*A1 + 1.733*A2-0.194* (E2/1000) and (b): P = EXP(X) / [1 + EXP(X)].

Conclusions: Using the aforementioned equations succeeded in determining the daily gonadotropin dose that might result in increasing oocyte yield, with an AUC of 0.85. Any additional oocyte retrieved to these EEF patients might get them closer to fulfil their desire to parenthood.

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确定促性腺激素的最佳日剂量,以最大限度地提高选择性卵子冷冻周期的卵母细胞产量。
目的:卵巢刺激(OS)与高剂量的每日促性腺激素通常提供给尝试社会/选择性卵子冷冻的患者。然而,能够在连续试管婴儿周期中获得更多卵母细胞的最佳促性腺激素日剂量尚未确定,因此应加以确定:分析了所有在本院试管婴儿科接受社会/EEF治疗并连续两次尝试试管婴儿周期的妇女的数据,其中只有第一次尝试时使用的促性腺激素起始剂量为每日300IU。通过分析患者的特征和操作系统变量,试图建立一个逻辑模型,帮助确定在第二次EEF尝试中应向患者提供的每日促性腺激素剂量,以进一步提高其卵母细胞产量:对连续两次尝试试管婴儿周期的 313 名妇女进行了评估。通过逻辑回归模型,利用患者的个人数据建立了两个方程,以确定在连续周期中增加卵母细胞产量所需的促性腺激素日剂量。(a):X=-0.514+2.87*A1+1.733*A2-0.194*(E2/1000)和(b):P=EXP(X)/[1+EXP(X)]:使用上述公式成功地确定了可增加卵母细胞产量的促性腺激素日剂量,其 AUC 为 0.85。任何额外的卵母细胞都可能使这些EEF患者更接近于实现为人父母的愿望。
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来源期刊
Reproductive Biology and Endocrinology
Reproductive Biology and Endocrinology 医学-内分泌学与代谢
CiteScore
7.90
自引率
2.30%
发文量
161
审稿时长
4-8 weeks
期刊介绍: Reproductive Biology and Endocrinology publishes and disseminates high-quality results from excellent research in the reproductive sciences. The journal publishes on topics covering gametogenesis, fertilization, early embryonic development, embryo-uterus interaction, reproductive development, pregnancy, uterine biology, endocrinology of reproduction, control of reproduction, reproductive immunology, neuroendocrinology, and veterinary and human reproductive medicine, including all vertebrate species.
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