Yi-Fei Yao , Wei Ni , Yong-Sheng Zhou , Huan Yan , Hai-Yang Liu
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引用次数: 0
Abstract
Three new dammarane-type triterpenoid saponins, namely 6′-crotonyl-(20 S)-ginsenoside Rg3 (1), 6′-crotonyl-(20 R)-ginsenoside Rg3 (2), and notoginsenolide A (3), were isolated from the steamed Panax notoginseng. Among them, 3 is the first tetranordamarane triterpenoid glucoside with an α, β-unsaturated γ-lactone group. The three isolates were evaluated for their cytotoxicities against five human cancer cell lines (HL-60, A-549, SMMC-7721, MDA-MB-231, and SW480). The results showed that compound 1 had moderate cytotoxicity against HL-60 cell line with an IC50 value of 23.39 μM.
期刊介绍：
Phytochemistry Letters invites rapid communications on all aspects of natural product research including:
• Structural elucidation of natural products
• Analytical evaluation of herbal medicines
• Clinical efficacy, safety and pharmacovigilance of herbal medicines
• Natural product biosynthesis
• Natural product synthesis and chemical modification
• Natural product metabolism
• Chemical ecology
• Biotechnology
• Bioassay-guided isolation
• Pharmacognosy
• Pharmacology of natural products
• Metabolomics
• Ethnobotany and traditional usage
• Genetics of natural products
Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.
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