Homoflavonoids and other constituents from Brenania brieyi De Wild (Rubiaceae) with their bioactivities

IF 1.3 4区生物学 Q4 CHEMISTRY, MEDICINAL Phytochemistry Letters Pub Date : 2025-02-03 DOI:10.1016/j.phytol.2025.01.1000

Ingrid Ornella Tchakouamo Matefo , Kevine Johane Dongmo Jumeta , Billy Toussie Tchegnitegni , Noella Molisa Efange , Lawrence Ayong , Yannick Stéphane Fotsing Fongang , Jean Jules Kezetas Bankeu , Jean Rodolphe Chouna , Norbert Sewald , Bruno Ndjakou Lenta

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Abstract

The chemical investigation of the CH₂Cl₂/MeOH (1:1, v/v) extract of the leaves and the stem bark of Brenania brieyi (Rubiaceae), which displayed antiplasmodial activity during preliminary screening resulted in the isolation of a new saponin (1), two new homoflavonoids (2 and 3) alongside 21 known compounds (424). Their structures were elucidated on the basis of their spectrometric and spectroscopic data, and by chemical reactions. All the compounds were isolated for the first time from the genus Brenania. Furthermore, fractions and some of the isolated compounds were assessed in vitro for their antiplasmodial potency against the chloroquine-sensitive strain of Plasmodium falciparum 3D7 (Pf3D7) and for their antibacterial activity against Escherichia coli 35218, Salmonella typhi CPC, Staphylococcus aureus 700098 and Pseudomonas aeruginosa HM 801. The extracts and fractions displayed moderate to good antiplasmodial activity with IC₅₀ values ranging from 12.17 to 32.63 µg/mL. Compounds 5, 7, 19, and 21 exhibited moderate antiplasmodial activity while the other tested compounds were inactive. Regarding the antibacterial activity, compounds 2 and 23 exhibited potent antibacterial activity against at least one tested strain with MIC values between 8.313 and 19.423 µM.

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.

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