Rapid spectrophotometric determination and extraction of platinum(IV) from pharmaceuticals assisted by 2-(2-(1-(thiophene-2-yl) ethylidene) hydrazinyl) benzoic acid (TEHBA)

IF 1.8 4区 化学 Q3 CHEMISTRY, ANALYTICAL Analytical Sciences Pub Date : 2024-06-17 DOI:10.1007/s44211-024-00612-9
Amruta Murkute, Haribhau Aher, Somnath Bhumkar, Shashikant Kuchekar
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Abstract

It has been suggested that the chelating agent 2-(2-(1-thiophene-2-yl) ethylidene) hydrazinyl) benzoic acid (TEHBA) be utilized to extract, separate and measure platinum(IV) by UV–visible spectrophotometry at the microgram level. Following 5 min of heating the reaction mixture in a water bath, Pt(IV)-TEHBA complex formed. This complex was formed in the presence of potassium iodide solution with a molar absorption coefficient 1.9 × 103 dm3 mol−1 cm−1. At 420 nm, the substance exhibited the greatest absorption. As Beer’s law described, the Pt(IV)-TEHBA complex for platinum(IV) has a beer’s range of 10–50 μg cm−3. It was determined that the proportion ratio of the Pt(IV)-TEHBA complex was 1:1 after its extraction. Despite the investigation of interference from various ions, it was ascertained that the method exhibited selectivity exclusively towards platinum(IV). The trace amounts of platinum(IV) were extracted and quantified from synthetic mixtures representing alloys, binaries and ternary synthetic mixtures. The process of extracting platinum(IV) from pharmaceutical samples involves the implementation of a specific method. Moreover, the procedure exhibits a progressive segregation of palladium(II), platinum(IV) and nickel(II) while also boasting its ease of operation.

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用 2-(2-(1-(噻吩-2-基)亚乙基)肼基)苯甲酸 (TEHBA) 辅助快速分光光度法测定和萃取药物中的铂(IV)。
有人建议利用螯合剂 2-(2-(1-噻吩-2-基)亚乙基)肼基苯甲酸(TEHBA)来提取、分离铂(IV),并通过紫外可见分光光度法进行微克级测量。在水浴中加热反应混合物 5 分钟后,铂(IV)-TEHBA 复合物形成。这种络合物是在碘化钾溶液中形成的,摩尔吸收系数为 1.9 × 103 dm3 mol-1 cm-1。在 420 纳米波长处,该物质的吸收率最大。根据比尔定律,铂(IV)-TEHBA 复合物的比尔范围为 10-50 μg cm-3。经测定,铂(IV)-TEHBA 复合物提取后的比例为 1:1。尽管调查了各种离子的干扰,但确定该方法只对铂(IV)具有选择性。从代表合金、二元和三元合成混合物中萃取并定量了铂(IV)的痕量。从药物样品中提取铂(IV)的过程需要采用特定的方法。此外,该方法还能逐步分离钯(II)、铂(IV)和镍(II),而且操作简便。
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来源期刊
Analytical Sciences
Analytical Sciences 化学-分析化学
CiteScore
2.90
自引率
18.80%
发文量
232
审稿时长
1 months
期刊介绍: Analytical Sciences is an international journal published monthly by The Japan Society for Analytical Chemistry. The journal publishes papers on all aspects of the theory and practice of analytical sciences, including fundamental and applied, inorganic and organic, wet chemical and instrumental methods. This publication is supported in part by the Grant-in-Aid for Publication of Scientific Research Result of the Japanese Ministry of Education, Culture, Sports, Science and Technology.
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