Incidence of side effects of antituberculosis drugs and their related factors in northern Iran: a retrospective cohort study.

IF 1.7 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH GMS Hygiene and Infection Control Pub Date : 2024-05-17 eCollection Date: 2024-01-01 DOI:10.3205/dgkh000482

Motahareh Kheradmand, Mahdi Afshari, Mohsen Aarabi, Siavosh Abedi, Mohammadreza Parsaee, Asghar Nezammahalleh, Mahmood Moosazadeh

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Abstract

Background: Antituberculosis drugs may cause mild, moderate or severe adverse drug reactions (ADR) leading to poor compliance. Description of the pattern of ADR and their related factors can help tuberculosis (TB) control program as part of the WHO programs. This study aims to investigate the incidence of ADR and associated factors among TB patients in northern Iran.

Methods: This is a retrospective cohort study. The required information, including year of diagnosis, age, gender, residence area, nationality, HIV co-morbidity, history of anti TB treatment and ADR, was obtained from the Deputy of Health, Mazandaran University of Medical Sciences, Iran. All data were analyzed using SPSS version 21 software.

Results: Out of 3903 TB patients, 136 (3.5%) experienced major ADR. The incidence of ADR for men and women as well as for those with and without previous treatment history were 3.9% vs. 3.3% and 5.3% vs. 3.4%, respectively (p>0.05). Multiple logistic regression models showed a higher chance of ADR among those aged over 59 compared with those aged under 29 (OR=2.63, 95% confidence interval: 1.54-4.49).

Conclusions: Age over 59 can be considered a risk factor for ADR with anti-TB drug administration.

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伊朗北部抗结核药物副作用的发生率及其相关因素：一项回顾性队列研究。

背景：抗结核药物可能会引起轻度、中度或严重的药物不良反应（ADR），从而导致用药依从性差。作为世界卫生组织计划的一部分，描述药物不良反应的模式及其相关因素有助于结核病（TB）控制计划。本研究旨在调查伊朗北部肺结核患者的药物不良反应发生率及其相关因素：这是一项回顾性队列研究。所需信息，包括诊断年份、年龄、性别、居住地区、国籍、HIV 并发症、抗结核治疗史和 ADR，均从伊朗马赞达兰医科大学卫生副校长处获得。所有数据均使用 SPSS 21 版软件进行分析：在 3903 名肺结核患者中，136 人（3.5%）出现了严重的 ADR。男性和女性以及有和无既往治疗史患者的 ADR 发生率分别为 3.9% vs. 3.3% 和 5.3% vs. 3.4% （P>0.05）。多元逻辑回归模型显示，59岁以上人群发生ADR的几率高于29岁以下人群（OR=2.63，95%置信区间：1.54-4.49）：结论：59 岁以上可被视为服用抗结核药物发生 ADR 的风险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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