{"title":"Isoquercetin Neuroprotective Molecular Targets in Parkinson’s Disease: Recent Highlights and Future Perspectives","authors":"Dilpreet Kaur, Shamsher Singh","doi":"10.2174/0115701808294683240531111346","DOIUrl":null,"url":null,"abstract":"\n\nParkinson's disease (PD) is an age-related progressive neurodegenerative condition characterized\nby dopaminergic neuronal loss in the brain's substantia nigra pars compacta (SNpc). Growing\nevidence suggests that apoptosis, neuroinflammation, mitochondrial dysfunction, and oxidative\nstress are important factors in the pathogenesis of Parkinson's disease. Isoquercetin is a natural flavanol\ncompound possessing anti-apoptotic, anti-inflammatory, anti-oxidant, and neuroprotective\nactivities. Isoquercetin also has the capability to modulate various signaling pathways such as Rho\nsignaling cascade, Nrf-2, TLR4, NF-κB, MAPK, Bcl-2, Bax proteins, which are well-known causes\nfor the progression of the disease. These pathways are involved in cellular homeostasis, transcription\nof proinflammatory cytokines, oxidative stress, microglial activation, and regulation of the apoptotic\npathways. In this review, we have highlighted the mechanisms of the above-mentioned pathways and\ntheir modulation via the flavonoid compound isoquercetin in various ways.\n","PeriodicalId":18063,"journal":{"name":"Letters in Drug Design & Discovery","volume":" 3","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Letters in Drug Design & Discovery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/0115701808294683240531111346","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Parkinson's disease (PD) is an age-related progressive neurodegenerative condition characterized
by dopaminergic neuronal loss in the brain's substantia nigra pars compacta (SNpc). Growing
evidence suggests that apoptosis, neuroinflammation, mitochondrial dysfunction, and oxidative
stress are important factors in the pathogenesis of Parkinson's disease. Isoquercetin is a natural flavanol
compound possessing anti-apoptotic, anti-inflammatory, anti-oxidant, and neuroprotective
activities. Isoquercetin also has the capability to modulate various signaling pathways such as Rho
signaling cascade, Nrf-2, TLR4, NF-κB, MAPK, Bcl-2, Bax proteins, which are well-known causes
for the progression of the disease. These pathways are involved in cellular homeostasis, transcription
of proinflammatory cytokines, oxidative stress, microglial activation, and regulation of the apoptotic
pathways. In this review, we have highlighted the mechanisms of the above-mentioned pathways and
their modulation via the flavonoid compound isoquercetin in various ways.
帕金森病(Parkinson's disease,PD)是一种与年龄相关的进行性神经退行性疾病,其特征是大脑黑质下部(substantia nigra pars compacta,SNpc)多巴胺能神经元的丧失。越来越多的证据表明,细胞凋亡、神经炎症、线粒体功能障碍和氧化应激是帕金森病发病机制中的重要因素。异槲皮素是一种天然黄烷醇化合物,具有抗凋亡、抗炎、抗氧化和神经保护作用。异槲皮素还能调节各种信号通路,如Rhosignaling级联、Nrf-2、TLR4、NF-κB、MAPK、Bcl-2、Bax蛋白,这些都是众所周知的导致疾病进展的原因。这些通路参与了细胞平衡、促炎细胞因子转录、氧化应激、小胶质细胞活化和凋亡通路的调节。在这篇综述中,我们重点介绍了上述途径的机制,以及通过类黄酮化合物异槲皮素以各种方式对其进行调节的机制。