Engineering of hierarchical mesoporous silica nanoparticles via control over surfactant nanoarchitectonics for biological applications

IF 7.9 2区化学 Q1 CHEMISTRY, PHYSICAL Current Opinion in Colloid & Interface Science Pub Date : 2024-06-06 DOI:10.1016/j.cocis.2024.101819

Yang Yang, Jingcheng Hao, Jiwei Cui

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Abstract

Compared to conventional mesoporous silica nanoparticles (MSNs) with ordered porous structures, hierarchical MSNs (HMSNs) have attracted increasing research interests in biological fields, owing to their highly porous structures with multiple distinct interfaces, which create more possibilities to explore complex biological realms. However, due to the structural complexity, the controllable assembly of HMSNs with desired nanostructures and well-defined particle properties is challenging. Herein, we review the advances of engineering HMSNs via control over surfactant nanoarchitectonics and discuss the synthesis-guiding principles and formation mechanisms. Based on the structural features of HMSNs, the corresponding bio-applications (e.g., macromolecule encapsulation, drug release, biointerface adhesion, immune cell activation and stimuli-responsive target motion) are summarized, highlighting the importance of structure–activity relationship. Challenges and future perspectives are also proposed for characterizations and extended applications of HMSNs.

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通过控制表面活性剂纳米结构设计分层介孔二氧化硅纳米颗粒，用于生物应用

与具有有序多孔结构的传统介孔二氧化硅纳米粒子（MSNs）相比，分层介孔二氧化硅纳米粒子（HMSNs）因其具有多个不同界面的高多孔结构，为探索复杂的生物领域创造了更多可能性，因而在生物领域吸引了越来越多的研究兴趣。然而，由于其结构的复杂性，要可控地组装出具有所需纳米结构和明确颗粒特性的 HMSNs 具有挑战性。在此，我们回顾了通过控制表面活性剂纳米结构来设计 HMSNs 的研究进展，并讨论了其合成指导原则和形成机制。根据 HMSNs 的结构特征，总结了相应的生物应用（如大分子封装、药物释放、生物界面粘附、免疫细胞活化和刺激响应目标运动），强调了结构-活性关系的重要性。此外，还就 HMSNs 的表征和扩展应用提出了挑战和未来展望。

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来源期刊

Current Opinion in Colloid & Interface Science 化学-物理化学

CiteScore

16.50

自引率

1.10%

发文量

审稿时长

11.3 weeks

期刊介绍： Current Opinion in Colloid and Interface Science (COCIS) is an international journal that focuses on the molecular and nanoscopic aspects of colloidal systems and interfaces in various scientific and technological fields. These include materials science, biologically-relevant systems, energy and environmental technologies, and industrial applications. Unlike primary journals, COCIS primarily serves as a guide for researchers, helping them navigate through the vast landscape of recently published literature. It critically analyzes the state of the art, identifies bottlenecks and unsolved issues, and proposes future developments. Moreover, COCIS emphasizes certain areas and papers that are considered particularly interesting and significant by the Editors and Section Editors. Its goal is to provide valuable insights and updates to the research community in these specialized areas.

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