Hepatotoxicity of usnic acid and underlying mechanisms.

IF 1.2 4区 环境科学与生态学 Q4 ENVIRONMENTAL SCIENCES Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Pub Date : 2024-06-21 DOI:10.1080/26896583.2024.2366737
Si Chen, Zhen Ren, Lei Guo
{"title":"Hepatotoxicity of usnic acid and underlying mechanisms.","authors":"Si Chen, Zhen Ren, Lei Guo","doi":"10.1080/26896583.2024.2366737","DOIUrl":null,"url":null,"abstract":"<p><p>Since usnic acid was first isolated in 1844 as a prominent secondary lichen metabolite, it has been used for various purposes worldwide. Usnic acid has been claimed to possess numerous therapeutic properties, including antimicrobial, anti-inflammatory, antiviral, anti-proliferative, and antipyretic activities. Approximately two decades ago, crude extracts of usnic acid or pure usnic acid were marketed in the United States as dietary supplements for aiding in weight loss as a \"fat-burner\" and gained popularity in the bodybuilding community; however, hepatotoxicity was documented for some usnic acid containing products. The US Food and Drug Administration (FDA) received numerous reports of liver toxicity associated with the use of dietary supplements containing usnic acid, leading the FDA to issue a warning letter in 2001 on a product, LipoKinetix. The FDA also sent a recommendation letter to the manufacturer of LipoKinetix, resulting in the withdrawal of LipoKinetix from the market. These events triggered investigations into the hepatotoxicity of usnic acid and its mechanisms. In 2008, we published a review article titled \"Usnic Acid and Usnea Barbata Toxicity\". This review is an updated version of our previous review article and incorporates additional data published since 2008. The purpose of this review is to provide a comprehensive summary of the understanding of the liver toxicity associated with usnic acid, with a particular focus on the current understanding of the putative mechanisms of usnic acid-related hepatotoxicity.</p>","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":" ","pages":"1-22"},"PeriodicalIF":1.2000,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","FirstCategoryId":"93","ListUrlMain":"https://doi.org/10.1080/26896583.2024.2366737","RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}
引用次数: 0

Abstract

Since usnic acid was first isolated in 1844 as a prominent secondary lichen metabolite, it has been used for various purposes worldwide. Usnic acid has been claimed to possess numerous therapeutic properties, including antimicrobial, anti-inflammatory, antiviral, anti-proliferative, and antipyretic activities. Approximately two decades ago, crude extracts of usnic acid or pure usnic acid were marketed in the United States as dietary supplements for aiding in weight loss as a "fat-burner" and gained popularity in the bodybuilding community; however, hepatotoxicity was documented for some usnic acid containing products. The US Food and Drug Administration (FDA) received numerous reports of liver toxicity associated with the use of dietary supplements containing usnic acid, leading the FDA to issue a warning letter in 2001 on a product, LipoKinetix. The FDA also sent a recommendation letter to the manufacturer of LipoKinetix, resulting in the withdrawal of LipoKinetix from the market. These events triggered investigations into the hepatotoxicity of usnic acid and its mechanisms. In 2008, we published a review article titled "Usnic Acid and Usnea Barbata Toxicity". This review is an updated version of our previous review article and incorporates additional data published since 2008. The purpose of this review is to provide a comprehensive summary of the understanding of the liver toxicity associated with usnic acid, with a particular focus on the current understanding of the putative mechanisms of usnic acid-related hepatotoxicity.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
烟酸的肝毒性及其潜在机制
自从 1844 年首次分离出作为一种重要的地衣次生代谢物的鸟苷酸以来,鸟苷酸已在全球范围内被用于各种用途。据称,鸟苷酸具有多种治疗特性,包括抗菌、消炎、抗病毒、抗增殖和解热等活性。大约二十年前,美国市场上出现了作为 "脂肪燃烧剂 "帮助减肥的膳食补充剂的野葛根酸粗提取物或纯野葛根酸,并在健美界大受欢迎;然而,一些含有野葛根酸的产品出现了肝毒性。美国食品和药物管理局(FDA)收到了许多与使用含烟酸的膳食补充剂有关的肝脏毒性报告,导致 FDA 于 2001 年对一种名为 LipoKinetix 的产品发出了警告信。美国食品及药物管理局还向 LipoKinetix 的制造商发出了建议信,导致 LipoKinetix 退出市场。这些事件引发了对烟酸肝毒性及其机制的调查。2008 年,我们发表了一篇题为 "乌司尼酸和巴巴塔乌司尼酸毒性 "的综述文章。本综述是我们上一篇综述文章的更新版,并纳入了 2008 年以来发表的更多数据。本综述的目的是全面总结人们对与鸟苷酸有关的肝脏毒性的认识,尤其侧重于目前对鸟苷酸相关肝毒性假定机制的认识。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
CiteScore
4.60
自引率
0.00%
发文量
10
期刊最新文献
An efficient enzymatic system for studying structure-carcinogenicity relationships: metabolism of pyrrolizidine alkaloids by human liver microsomes in the presence of calf thymus DNA, resulting in the formation of DNA adducts. Reconsideration of the health effects of monosodium glutamate: from bench to bedside evidence. Unlocking the potential of AI: Machine learning and deep learning models for predicting carcinogenicity of chemicals. Hepatotoxicity of usnic acid and underlying mechanisms. Heavy metal and microbial testing of selected cosmetic products in the Palestinian market.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1