Aspartic acid-Cu(Ⅱ)-based nanozymes for combating bacterial infections

IF 2.7 4区材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY Materials Letters Pub Date : 2024-06-18 DOI:10.1016/j.matlet.2024.136876

Yiting Cao, Yawei Chen, Jiajia Yang, Tongtong Zhang, Huiyun Zhou

{"title":"Aspartic acid-Cu(Ⅱ)-based nanozymes for combating bacterial infections","authors":"Yiting Cao, Yawei Chen, Jiajia Yang, Tongtong Zhang, Huiyun Zhou","doi":"10.1016/j.matlet.2024.136876","DOIUrl":null,"url":null,"abstract":"<div><p>Nanozymes based on the coordination of amino acids and metal ions exhibit pronounced peroxidase (POD)-like activity, holding promising prospects in mitigating bacterial resistance caused by antibiotic misuse and harboring tremendous potential in the treatment of bacterial infections. In this study, L-/D-aspartic acid (L-/D-Asp) were individually coordinated with copper ions using a simple self-assembly approach, culminating in the creation of L-/D-hydrogel and nanofibers (L-/D-Gel and NFs) with POD-like actiity. These materials displayed excellent inhibitory effects against <em>Escherichia coli (E. coli)</em> and <em>Staphylococcus aureus (S. aureus)</em>. Particularly, compared to L-/D-Gel, L-/D-NFs demonstrated excellent catalytic activity at extremely low concentrations. Moreover, our prepared nanozymes exhibited higher catalytic activity over a broader range of temperature and pH levels compared to the natural enzyme horseradish peroxidase (HRP). In summary, the prepared L-/D-Gel and NFs, as a novel type of nanozyme, hold great promise for widespread applications in the treatment of bacterial infections in wounds.</p></div>","PeriodicalId":384,"journal":{"name":"Materials Letters","volume":null,"pages":null},"PeriodicalIF":2.7000,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Materials Letters","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0167577X24010152","RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

Nanozymes based on the coordination of amino acids and metal ions exhibit pronounced peroxidase (POD)-like activity, holding promising prospects in mitigating bacterial resistance caused by antibiotic misuse and harboring tremendous potential in the treatment of bacterial infections. In this study, L-/D-aspartic acid (L-/D-Asp) were individually coordinated with copper ions using a simple self-assembly approach, culminating in the creation of L-/D-hydrogel and nanofibers (L-/D-Gel and NFs) with POD-like actiity. These materials displayed excellent inhibitory effects against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). Particularly, compared to L-/D-Gel, L-/D-NFs demonstrated excellent catalytic activity at extremely low concentrations. Moreover, our prepared nanozymes exhibited higher catalytic activity over a broader range of temperature and pH levels compared to the natural enzyme horseradish peroxidase (HRP). In summary, the prepared L-/D-Gel and NFs, as a novel type of nanozyme, hold great promise for widespread applications in the treatment of bacterial infections in wounds.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

基于天冬氨酸-铜(Ⅱ)的抗细菌感染纳米酶

基于氨基酸和金属离子配位的纳米酶表现出明显的过氧化物酶（POD）活性，在缓解滥用抗生素导致的细菌耐药性方面前景广阔，在治疗细菌感染方面潜力巨大。在这项研究中，采用简单的自组装方法将 L-/D- 天冬氨酸（L-/D-Asp）与铜离子单独配位，最终生成了具有 POD 类活性的 L-/D- 水凝胶和纳米纤维（L-/D-凝胶和 NFs）。这些材料对大肠杆菌（E. coli）和金黄色葡萄球菌（S. aureus）有很好的抑制作用。特别是，与 L-/D-Gel 相比，L-/D-NFs 在极低浓度下就能表现出卓越的催化活性。此外，与天然酶辣根过氧化物酶（HRP）相比，我们制备的纳米酶在更宽的温度和 pH 值范围内表现出更高的催化活性。总之，制备的 L-/D-Gel 和 NFs 作为一种新型纳米酶，有望广泛应用于伤口细菌感染的治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Materials Letters 工程技术-材料科学：综合

CiteScore

5.60

自引率

3.30%

发文量

1948

审稿时长

50 days

期刊介绍： Materials Letters has an open access mirror journal Materials Letters: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Materials Letters is dedicated to publishing novel, cutting edge reports of broad interest to the materials community. The journal provides a forum for materials scientists and engineers, physicists, and chemists to rapidly communicate on the most important topics in the field of materials. Contributions include, but are not limited to, a variety of topics such as: • Materials - Metals and alloys, amorphous solids, ceramics, composites, polymers, semiconductors • Applications - Structural, opto-electronic, magnetic, medical, MEMS, sensors, smart • Characterization - Analytical, microscopy, scanning probes, nanoscopic, optical, electrical, magnetic, acoustic, spectroscopic, diffraction • Novel Materials - Micro and nanostructures (nanowires, nanotubes, nanoparticles), nanocomposites, thin films, superlattices, quantum dots. • Processing - Crystal growth, thin film processing, sol-gel processing, mechanical processing, assembly, nanocrystalline processing. • Properties - Mechanical, magnetic, optical, electrical, ferroelectric, thermal, interfacial, transport, thermodynamic • Synthesis - Quenching, solid state, solidification, solution synthesis, vapor deposition, high pressure, explosive