Strategies for the development of metalloimmunotherapies

IF 26.8 1区医学 Q1 ENGINEERING, BIOMEDICAL Nature Biomedical Engineering Pub Date : 2024-06-24 DOI:10.1038/s41551-024-01221-7

Xiaoqi Sun, Xingwu Zhou, Xiaoyue Shi, Omar A. Abed, Xinran An, Yu Leo Lei, James J. Moon

引用次数: 0

Abstract

Metal ions play crucial roles in the regulation of immune pathways. In fact, metallodrugs have a long record of accomplishment as effective treatments for a wide range of diseases. Here we argue that the modulation of interactions of metal ions with molecules and cells involved in the immune system forms the basis of a new class of immunotherapies. By examining how metal ions modulate the innate and adaptive immune systems, as well as host–microbiota interactions, we discuss strategies for the development of such metalloimmunotherapies for the treatment of cancer and other immune-related diseases. This Perspective examines how metal ions modulate the immune system and host–microbiota interactions, and proposes strategies for the development of metal-ion-based immunotherapies.

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开发金属免疫疗法的策略

金属离子在调节免疫途径方面发挥着至关重要的作用。事实上，金属药物作为治疗多种疾病的有效药物已有悠久的历史。在此，我们认为，调节金属离子与免疫系统中的分子和细胞之间的相互作用是新型免疫疗法的基础。通过研究金属离子如何调节先天性免疫系统和适应性免疫系统以及宿主与微生物群之间的相互作用，我们探讨了开发此类金属免疫疗法治疗癌症和其他免疫相关疾病的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Biomedical Engineering Medicine-Medicine (miscellaneous)

CiteScore

45.30

自引率

1.10%

发文量

138

期刊介绍： Nature Biomedical Engineering is an online-only monthly journal that was launched in January 2017. It aims to publish original research, reviews, and commentary focusing on applied biomedicine and health technology. The journal targets a diverse audience, including life scientists who are involved in developing experimental or computational systems and methods to enhance our understanding of human physiology. It also covers biomedical researchers and engineers who are engaged in designing or optimizing therapies, assays, devices, or procedures for diagnosing or treating diseases. Additionally, clinicians, who make use of research outputs to evaluate patient health or administer therapy in various clinical settings and healthcare contexts, are also part of the target audience.

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