The therapeutic potential of indole hybrids, dimers, and trimers against drug-resistant ESKAPE pathogens

IF 4.3 3区医学 Q2 CHEMISTRY, MEDICINAL Archiv der Pharmazie Pub Date : 2024-06-26 DOI:10.1002/ardp.202400295

Ye Qiongxian, Deng Jun, Zhang Zhenfeng, Luo Tongyou, Tan Zhicong, Tan Zhenyou

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Abstract

Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter (ESKAPE) species as causative agents are characterized by increased levels of resistance toward multiple classes of first-line as well as last-resort antibiotics and represent serious global health concerns, creating a critical need for the development of novel antibacterials with therapeutic potential against drug-resistant ESKAPE species. Indole derivatives with structural and mechanistic diversity demonstrated broad-spectrum antibacterial activity against various clinically important pathogens including drug-resistant ESKAPE. Moreover, several indole-based agents that are exemplified by creatmycin have already been used in clinics or under clinical trials for the treatment of bacterial infections, demonstrating that indole derivatives hold great promise for the development of novel antibacterials. This review is an endeavor to highlight the current scenario of indole hybrids, dimers, and trimers with therapeutic potential against drug-resistant ESKAPE pathogens, covering articles published from 2020 to the present, to open new avenues for the exploration of novel antidrug-resistant ESKAPE candidates.

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吲哚混合物、二聚体和三聚体对耐药性 ESKAPE 病原体的治疗潜力。

粪肠球菌、金黄色葡萄球菌、肺炎克雷伯氏菌、鲍曼不动杆菌、铜绿假单胞菌和肠杆菌（ESKAPE）作为致病菌，对多类一线抗生素和最后手段抗生素的耐药性不断增加，是严重的全球健康问题，因此亟需开发具有治疗潜力的新型抗菌药物来对付耐药 ESKAPE 物种。具有结构和机理多样性的吲哚衍生物对包括耐药 ESKAPE 在内的各种临床重要病原体具有广谱抗菌活性。此外，以 creatmycin 为代表的几种吲哚类药物已经用于临床或正在进行临床试验，用于治疗细菌感染，这表明吲哚衍生物在开发新型抗菌药物方面大有可为。本综述旨在重点介绍具有抗耐药性 ESKAPE 病原体治疗潜力的吲哚杂化物、二聚体和三聚体的现状，涵盖 2020 年至今发表的文章，为探索新型抗耐药性 ESKAPE 候选药物开辟新途径。

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来源期刊

Archiv der Pharmazie 医学-化学综合

CiteScore

7.90

自引率

5.90%

发文量

176

审稿时长

3.0 months

期刊介绍： Archiv der Pharmazie - Chemistry in Life Sciences is an international journal devoted to research and development in all fields of pharmaceutical and medicinal chemistry. Emphasis is put on papers combining synthetic organic chemistry, structural biology, molecular modelling, bioorganic chemistry, natural products chemistry, biochemistry or analytical methods with pharmaceutical or medicinal aspects such as biological activity. The focus of this journal is put on original research papers, but other scientifically valuable contributions (e.g. reviews, minireviews, highlights, symposia contributions, discussions, and essays) are also welcome.