GnRH Vaccine Could Suppress Serum Testosterone in Stallion Mules.

IF 2.7 2区农林科学 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE Animals Pub Date : 2024-06-17 DOI:10.3390/ani14121800

Siriporn Khumsap, Sahatchai Tangtrongsup, Patcharapa Towiboon, Chaleamchat Somgird

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Abstract

Stallion mules have been used as working equids in several countries. Aggressiveness under the influence of testosterone results in the necessity for surgical castration before work training. The gonadotropin-releasing hormone (GnRH) vaccine may be an alternative method for immunocastration in mules. The objective of this study was to evaluate the effect of the GnRH vaccine on anti-GnRH antibody concentration, serum testosterone concentration, clinical adverse effects, and behavioral changes in response to receiving selected physical manipulations from humans. Twenty-five mules were separated into three groups: Control-intact, Control-castrated, and Treatment. The Treatment group was further divided according to condition (intact or unilateral cryptorchid) and age. The Treatment group received 195 µg of the GnRH vaccine intramuscularly at weeks 0, 4, and 8. The anti-GnRH antibody concentrations increased at weeks 6 and 10, and then they gradually decreased to baseline at week 24. The Treatment-intact-young group had the highest concentration of anti-GnRH antibody. The serum testosterone concentrations in the Treatment group were lower than before vaccination from weeks 6 to 14. Subcutaneous edema adjacent to the injection site was detected in the Treatment-intact group after booster vaccination. In conclusion, the mules responded to the GnRH vaccine, which could temporarily suppress testosterone for up to 14 weeks.

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GnRH 疫苗可抑制种公骡的血清睾酮。

在一些国家，种骡被用作工作马。骡子在睾丸激素的影响下具有攻击性，因此必须在工作训练前进行手术阉割。促性腺激素释放激素（GnRH）疫苗可能是骡子免疫阉割的替代方法。本研究的目的是评估 GnRH 疫苗对抗 GnRH 抗体浓度、血清睾酮浓度、临床不良反应以及接受人类特定物理操作后行为变化的影响。25 头骡子被分成三组：未接触对照组、阉割对照组和治疗组。治疗组又根据状况（完好或单侧隐睾）和年龄进一步划分。治疗组在第 0、4 和 8 周肌肉注射 195 µg GnRH 疫苗。抗GnRH抗体浓度在第6周和第10周升高，然后在第24周逐渐降至基线。治疗-接触-年轻组的抗GnRH抗体浓度最高。从第6周到第14周，治疗组的血清睾酮浓度低于接种前。加强免疫后，在治疗组的注射部位附近发现了皮下水肿。总之，骡子对 GnRH 疫苗有反应，该疫苗可暂时抑制睾酮长达 14 周。

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来源期刊

Animals Agricultural and Biological Sciences-Animal Science and Zoology

CiteScore

4.90

自引率

16.70%

发文量

3015

审稿时长

20.52 days

期刊介绍： Animals (ISSN 2076-2615) is an international and interdisciplinary scholarly open access journal. It publishes original research articles, reviews, communications, and short notes that are relevant to any field of study that involves animals, including zoology, ethnozoology, animal science, animal ethics and animal welfare. However, preference will be given to those articles that provide an understanding of animals within a larger context (i.e., the animals'' interactions with the outside world, including humans). There is no restriction on the length of the papers. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. Full experimental details and/or method of study, must be provided for research articles. Articles submitted that involve subjecting animals to unnecessary pain or suffering will not be accepted, and all articles must be submitted with the necessary ethical approval (please refer to the Ethical Guidelines for more information).