Arginine vasopressin in mood disorders: A potential biomarker of disease pathology and a target for pharmacologic intervention.

IF 5 3区 医学 Q1 CLINICAL NEUROLOGY Psychiatry and Clinical Neurosciences Pub Date : 2024-09-01 Epub Date: 2024-06-25 DOI:10.1111/pcn.13703
Hiroe Hu, Carlos A Zarate, Joseph Verbalis
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Abstract

Vasopressin or arginine-vasopressin (AVP) is a neuropeptide molecule known for its antidiuretic effects and serves to regulate plasma osmolality and blood pressure. The existing literature suggests that AVP plays a multifaceted-though less well-known-role in the central nervous system (CNS), particularly in relation to the pathophysiology and treatment of mood disorders. Animal models have demonstrated that AVP is implicated in regulating social cognition, affiliative and prosocial behaviors, and aggression, often in conjunction with oxytocin. In humans, AVP is implicated in mood disorders through its effects on the hypothalamic-pituitary-adrenal (HPA) axis as well as on the serotoninergic and glutamatergic systems. Measuring plasma AVP has yielded interesting but mixed results in mood and stress-related disorders. Recent advances have led to the development of copeptin as a stable and reliable surrogate biomarker for AVP. Another interesting but relatively unexplored issue is the interaction between the osmoregulatory system and mood disorder pathophysiology, given that psychotropic medications often cause dysregulation of AVP receptor expression or signaling that can subsequently lead to clinical syndromes like syndrome of inappropriate diuresis and diabetes insipidus. Finally, pharmaceutical trials of agents that act on V1a and V1b receptor antagonists are still underway. This narrative review summarizes: (1) the neurobiology of the vasopressinergic system in the CNS; (2) the interaction between AVP and the monoaminergic and glutamatergic pathways in the pathophysiology and treatment of mood disorders; (3) the iatrogenic AVP dysregulation caused by psychotropic medications; and (4) the pharmaceutical development of AVP receptor antagonists for the treatment of mood disorders.

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情绪障碍中的精氨酸加压素:疾病病理的潜在生物标志物和药物干预的目标。
血管加压素或精氨酸-血管加压素(AVP)是一种神经肽分子,以其抗利尿作用而闻名,具有调节血浆渗透压和血压的作用。现有文献表明,AVP 在中枢神经系统(CNS)中发挥着多方面的作用,尤其是在情绪障碍的病理生理学和治疗方面,但人们对其了解较少。动物模型已经证明,AVP 与社会认知、从属和亲社会行为以及攻击行为有关,通常与催产素一起发挥作用。在人体中,通过对下丘脑-垂体-肾上腺(HPA)轴以及血清素能和谷氨酸能系统的影响,AVP 与情绪障碍有关。在情绪和压力相关疾病中,血浆 AVP 的测量结果令人感兴趣,但好坏参半。最近的研究进展导致 copeptin 成为 AVP 稳定可靠的替代生物标志物。另一个有趣但相对尚未探索的问题是渗透调节系统与情绪障碍病理生理学之间的相互作用,因为精神药物通常会导致 AVP 受体表达或信号传导失调,进而导致不适当利尿综合征和糖尿病性尿崩症等临床综合征。最后,作用于 V1a 和 V1b 受体拮抗剂的药物试验仍在进行中。本综述概述了:(1)中枢神经系统中血管加压素能系统的神经生物学;(2)在情绪障碍的病理生理学和治疗中 AVP 与单胺能和谷氨酸能通路之间的相互作用;(3)精神药物导致的先天性 AVP 失调;以及(4)用于治疗情绪障碍的 AVP 受体拮抗剂的药物开发。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
7.40
自引率
4.20%
发文量
181
审稿时长
6-12 weeks
期刊介绍: PCN (Psychiatry and Clinical Neurosciences) Publication Frequency: Published 12 online issues a year by JSPN Content Categories: Review Articles Regular Articles Letters to the Editor Peer Review Process: All manuscripts undergo peer review by anonymous reviewers, an Editorial Board Member, and the Editor Publication Criteria: Manuscripts are accepted based on quality, originality, and significance to the readership Authors must confirm that the manuscript has not been published or submitted elsewhere and has been approved by each author
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