Multivariate sharp-wave ripples in schizophrenia during awake state.

IF 5 3区 医学 Q1 CLINICAL NEUROLOGY Psychiatry and Clinical Neurosciences Pub Date : 2024-09-01 Epub Date: 2024-06-24 DOI:10.1111/pcn.13702
Takefumi Ohki, Zenas C Chao, Yuichi Takei, Yutaka Kato, Masakazu Sunaga, Tomohiro Suto, Minami Tagawa, Masato Fukuda
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Abstract

Aims: Schizophrenia (SZ) is a brain disorder characterized by psychotic symptoms and cognitive dysfunction. Recently, irregularities in sharp-wave ripples (SPW-Rs) have been reported in SZ. As SPW-Rs play a critical role in memory, their irregularities can cause psychotic symptoms and cognitive dysfunction in patients with SZ. In this study, we investigated the SPW-Rs in human SZ.

Methods: We measured whole-brain activity using magnetoencephalography (MEG) in patients with SZ (n = 20) and sex- and age-matched healthy participants (n = 20) during open-eye rest. We identified SPW-Rs and analyzed their occurrence and time-frequency traits. Furthermore, we developed a novel multivariate analysis method, termed "ripple-gedMEG" to extract the global features of SPW-Rs. We also examined the association between SPW-Rs and brain state transitions. The outcomes of these analyses were modeled to predict the positive and negative syndrome scale (PANSS) scores of SZ.

Results: We found that SPW-Rs in the SZ (1) occurred more frequently, (2) the delay of the coupling phase (3) appeared in different brain areas, (4) consisted of a less organized spatiotemporal pattern, and (5) were less involved in brain state transitions. Finally, some of the neural features associated with the SPW-Rs were found to be PANSS-positive, a pathological indicator of SZ. These results suggest that widespread but disorganized SPW-Rs underlies the symptoms of SZ.

Conclusion: We identified irregularities in SPW-Rs in SZ and confirmed that their alternations were strongly associated with SZ neuropathology. These results suggest a new direction for human SZ research.

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清醒状态下精神分裂症的多变量尖波涟漪。
目的:精神分裂症(SZ)是一种以精神病性症状和认知功能障碍为特征的脑部疾病。最近,有报道称精神分裂症患者的锐波波纹(SPW-Rs)不规则。由于SPW-Rs在记忆中起着关键作用,其不规则性可导致SZ患者出现精神症状和认知功能障碍。本研究调查了人类 SZ 中的 SPW-Rs:我们使用脑磁图(MEG)测量了SZ患者(20人)和性别、年龄匹配的健康参与者(20人)在睁眼休息时的全脑活动。我们确定了 SPW-Rs,并分析了它们的发生率和时间频率特征。此外,我们还开发了一种称为 "涟漪-gedMEG "的新型多变量分析方法,以提取 SPW-Rs 的全局特征。我们还研究了 SPW-Rs 与大脑状态转换之间的关联。这些分析结果被用来预测 SZ 的阳性和阴性综合征量表(PANSS)评分:我们发现,SPW-Rs在SZ中(1)出现的频率更高;(2)耦合阶段延迟;(3)出现在不同的脑区;(4)由组织性较差的时空模式组成;(5)较少参与脑状态转换。最后,与 SPW-Rs 相关的一些神经特征被发现呈 PANSS 阳性,这是 SZ 的病理指标。这些结果表明,广泛但无序的SPW-Rs是SZ症状的基础:我们发现了SPW-Rs在SZ中的不规则性,并证实其交替与SZ神经病理学密切相关。这些结果为人类 SZ 研究指明了新的方向。
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来源期刊
CiteScore
7.40
自引率
4.20%
发文量
181
审稿时长
6-12 weeks
期刊介绍: PCN (Psychiatry and Clinical Neurosciences) Publication Frequency: Published 12 online issues a year by JSPN Content Categories: Review Articles Regular Articles Letters to the Editor Peer Review Process: All manuscripts undergo peer review by anonymous reviewers, an Editorial Board Member, and the Editor Publication Criteria: Manuscripts are accepted based on quality, originality, and significance to the readership Authors must confirm that the manuscript has not been published or submitted elsewhere and has been approved by each author
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