Subpectineal obturator nerve block reduces opioid consumption after hip arthroscopy: a triple-blind, randomized, placebo-controlled trial.

IF 5.1 2区 医学 Q1 ANESTHESIOLOGY Regional Anesthesia and Pain Medicine Pub Date : 2024-06-25 DOI:10.1136/rapm-2024-105638
Christian Jessen, Ulrick Skipper Espelund, Lone Dragnes Brix, Thomas Dahl Nielsen, Bent Lund, Thomas Fichtner Bendtsen
{"title":"Subpectineal obturator nerve block reduces opioid consumption after hip arthroscopy: a triple-blind, randomized, placebo-controlled trial.","authors":"Christian Jessen, Ulrick Skipper Espelund, Lone Dragnes Brix, Thomas Dahl Nielsen, Bent Lund, Thomas Fichtner Bendtsen","doi":"10.1136/rapm-2024-105638","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Hip arthroscopy causes severe pain during the first few hours in the postoperative care unit. This is probably due to the intraoperative stretching of the hip joint capsule. Pain relief requires high doses of opioids which may prolong recovery and may cause opioid-related adverse events.The majority of hip joint capsule nociceptors are located anteriorly. The obturator nerve innervates the anteromedial part of the hip joint capsule. We hypothesized that a subpectineal obturator nerve block using 15 ml bupivacaine 5 mg/mL with added epinephrine 5 μg/mL would reduce the opioid consumption after hip arthroscopy.</p><p><strong>Methods: </strong>40 ambulatory hip arthroscopy patients were enrolled in this randomized, triple-blind controlled trial. All patients were allocated to a preoperative active or placebo subpectineal obturator nerve block. The primary outcome was opioid consumption for the first 3 hours in the postanesthesia care unit. Secondary outcomes were pain, nausea, and hip adductor strength.</p><p><strong>Results: </strong>34 patients were analyzed for the primary outcome. The mean intravenous morphine equivalent consumption in the subpectineal obturator nerve block group was 11.9 mg vs 19.7 mg in the placebo group (p<0.001). The hip adductor strength was significantly reduced in the active group. No other intergroup differences were observed regarding the secondary outcomes.</p><p><strong>Conclusion: </strong>We found a significant reduction in the opioid consumption for patients receiving an active subpectineal obturator nerve block. The postoperative intravenous morphine equivalent reduction the first painful 3 hours was reduced by 40% for patients receiving a subpectineal obturator nerve block in this randomized, triple-blind trial.</p><p><strong>Trial registration number: </strong>EudraCT database 2021-006575-42.</p>","PeriodicalId":54503,"journal":{"name":"Regional Anesthesia and Pain Medicine","volume":null,"pages":null},"PeriodicalIF":5.1000,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Regional Anesthesia and Pain Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1136/rapm-2024-105638","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ANESTHESIOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Hip arthroscopy causes severe pain during the first few hours in the postoperative care unit. This is probably due to the intraoperative stretching of the hip joint capsule. Pain relief requires high doses of opioids which may prolong recovery and may cause opioid-related adverse events.The majority of hip joint capsule nociceptors are located anteriorly. The obturator nerve innervates the anteromedial part of the hip joint capsule. We hypothesized that a subpectineal obturator nerve block using 15 ml bupivacaine 5 mg/mL with added epinephrine 5 μg/mL would reduce the opioid consumption after hip arthroscopy.

Methods: 40 ambulatory hip arthroscopy patients were enrolled in this randomized, triple-blind controlled trial. All patients were allocated to a preoperative active or placebo subpectineal obturator nerve block. The primary outcome was opioid consumption for the first 3 hours in the postanesthesia care unit. Secondary outcomes were pain, nausea, and hip adductor strength.

Results: 34 patients were analyzed for the primary outcome. The mean intravenous morphine equivalent consumption in the subpectineal obturator nerve block group was 11.9 mg vs 19.7 mg in the placebo group (p<0.001). The hip adductor strength was significantly reduced in the active group. No other intergroup differences were observed regarding the secondary outcomes.

Conclusion: We found a significant reduction in the opioid consumption for patients receiving an active subpectineal obturator nerve block. The postoperative intravenous morphine equivalent reduction the first painful 3 hours was reduced by 40% for patients receiving a subpectineal obturator nerve block in this randomized, triple-blind trial.

Trial registration number: EudraCT database 2021-006575-42.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
髋关节镜术后会阴下闭孔神经阻滞可减少阿片类药物的用量:一项三盲、随机、安慰剂对照试验。
背景:髋关节镜手术在术后监护室的最初几小时会引起剧烈疼痛。这可能是由于术中拉伸了髋关节囊。缓解疼痛需要大剂量的阿片类药物,这可能会延长恢复时间,并可能引起阿片类药物相关的不良反应。钝神经支配髋关节囊的前内侧部分。我们假设,使用 15 毫升布比卡因 5 毫克/毫升并添加肾上腺素 5 微克/毫升进行会阴下钝神经阻滞可减少髋关节镜术后的阿片类药物用量。所有患者均被分配接受术前活性或安慰剂脐下闭孔神经阻滞。主要结果是麻醉后护理病房前 3 小时的阿片类药物消耗量。次要结果是疼痛、恶心和髋关节内收肌力量:对 34 名患者进行了主要结果分析。结果:对 34 名患者进行了主要结果分析。脐下闭孔神经阻滞组的平均静脉注射吗啡当量消耗量为 11.9 毫克,而安慰剂组为 19.7 毫克(p 结论:我们发现脐下闭孔神经阻滞组的鸦片用量显著减少:我们发现,接受主动脐下闭孔神经阻滞的患者阿片类药物消耗量明显减少。在这项随机三盲试验中,接受瑜膜下闭孔神经阻滞的患者术后最初3小时疼痛时的静脉注射吗啡当量减少了40%:EudraCT 数据库 2021-006575-42。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
CiteScore
8.50
自引率
11.80%
发文量
175
审稿时长
6-12 weeks
期刊介绍: Regional Anesthesia & Pain Medicine, the official publication of the American Society of Regional Anesthesia and Pain Medicine (ASRA), is a monthly journal that publishes peer-reviewed scientific and clinical studies to advance the understanding and clinical application of regional techniques for surgical anesthesia and postoperative analgesia. Coverage includes intraoperative regional techniques, perioperative pain, chronic pain, obstetric anesthesia, pediatric anesthesia, outcome studies, and complications. Published for over thirty years, this respected journal also serves as the official publication of the European Society of Regional Anaesthesia and Pain Therapy (ESRA), the Asian and Oceanic Society of Regional Anesthesia (AOSRA), the Latin American Society of Regional Anesthesia (LASRA), the African Society for Regional Anesthesia (AFSRA), and the Academy of Regional Anaesthesia of India (AORA).
期刊最新文献
End-tidal carbon dioxide monitoring in spontaneously breathing patients: a low-cost strategy. Comparing modalities of opioid education in patients undergoing total knee arthroplasty: a randomized pilot trial. Peripheral nerve microanatomy: new insights into possible mechanisms for block success. Evolving Regional Anesthesiology and Acute Pain Medicine fellowship application process: a program director survey. Mortality in patients undergoing thoracotomy with continuous neuraxial analgesia.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1