Alan Bao, Xian Xia, Hao Wang, Qin Li, Chunmei Chen*, Yonghui Zhang* and Hucheng Zhu*,
{"title":"Diterpenoids with Antibacterial Activities from the Fungus Trichoderma harzianum","authors":"Alan Bao, Xian Xia, Hao Wang, Qin Li, Chunmei Chen*, Yonghui Zhang* and Hucheng Zhu*, ","doi":"10.1021/acs.jafc.4c00067","DOIUrl":null,"url":null,"abstract":"<p >A new fusicoccane diterpenoid, harziaderma A (<b>1</b>), two novel harziane diterpenoids, harzianones G and H (<b>2</b> and <b>3</b>), one revised harziane diterpenoid (<b>4</b>), and two known diterpenoids (<b>5</b> and <b>6</b>) were isolated from the fungus <i>Trichoderma harzianum</i> and established via NMR, HRESIMS, Mo<sub>2</sub>(OAc)<sub>4</sub>-induced circular dichroism (ICD) and electronic circular dichroism (ECD) calculations. It is worth noting that compound <b>1</b> represents the first instance of a fusicoccane-type diterpenoid derived from <i>T. harzianum</i>. The structure of furanharzianone B was revised to <b>4</b> via careful spectroscopic analyses. Additionally, compounds <b>2</b> and <b>5</b> could suppress the overall growth of the foodborne bacterial pathogen <i>Bacillus cereus</i>. Compound <b>4</b> showed a moderate suppressive impact on NO generation in lipopolysaccharide (LPS)-treated RAW 264.7 cells. The discoveries from the current study not only expanded the structural variety of diterpenoids isolated from <i>T. harzianum</i> but also laid a robust foundation for the development of harziane diterpenoids as anti-foodborne pathogen agents.</p>","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":null,"pages":null},"PeriodicalIF":5.7000,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Agricultural and Food Chemistry","FirstCategoryId":"97","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acs.jafc.4c00067","RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"AGRICULTURE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
A new fusicoccane diterpenoid, harziaderma A (1), two novel harziane diterpenoids, harzianones G and H (2 and 3), one revised harziane diterpenoid (4), and two known diterpenoids (5 and 6) were isolated from the fungus Trichoderma harzianum and established via NMR, HRESIMS, Mo2(OAc)4-induced circular dichroism (ICD) and electronic circular dichroism (ECD) calculations. It is worth noting that compound 1 represents the first instance of a fusicoccane-type diterpenoid derived from T. harzianum. The structure of furanharzianone B was revised to 4 via careful spectroscopic analyses. Additionally, compounds 2 and 5 could suppress the overall growth of the foodborne bacterial pathogen Bacillus cereus. Compound 4 showed a moderate suppressive impact on NO generation in lipopolysaccharide (LPS)-treated RAW 264.7 cells. The discoveries from the current study not only expanded the structural variety of diterpenoids isolated from T. harzianum but also laid a robust foundation for the development of harziane diterpenoids as anti-foodborne pathogen agents.
期刊介绍:
The Journal of Agricultural and Food Chemistry publishes high-quality, cutting edge original research representing complete studies and research advances dealing with the chemistry and biochemistry of agriculture and food. The Journal also encourages papers with chemistry and/or biochemistry as a major component combined with biological/sensory/nutritional/toxicological evaluation related to agriculture and/or food.