Feeding the Body Through the Skin: Ethosomes and Transethosomes as a New Topical Delivery System for Bioactive Compounds.

IF 10.6 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Annual review of food science and technology Pub Date : 2024-06-01 DOI:10.1146/annurev-food-072023-034528
Elisabetta Esposito, Alessandra Pecorelli, Francesca Ferrara, Mary Ann Lila, Giuseppe Valacchi
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Abstract

Because the feeding of our body through the oral route can be associated with many drawbacks due to the degradation of natural molecules during transit in the gastrointestinal tract, a transdermal delivery strategy, usually employed in the pharmaceutical field, can present an effective alternative for delivery of bioactives and nutrients from foods. In this review, the chance to feed the body with nutritive and bioactive molecules from food through transdermal administration is discussed. Various nanotechnological devices employed for topical and transdermal delivery of bioactive compounds are described. In addition, mechanisms underlying their potential use in the delivery of nutritive molecules, as well as their capability to efficaciously reach the dermis and promote systemic distribution, are detailed.

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通过皮肤喂养身体:Ethosomes and Transethosomes as a new Topical Delivery System for Bioactive Compounds.
由于天然分子在胃肠道中的转运过程中会发生降解,因此通过口服途径喂养人体会有许多弊端,而通常在制药领域采用的透皮给药策略,则可以为从食物中提供生物活性物质和营养物质提供一种有效的替代方法。本综述将讨论通过透皮给药从食物中向人体提供营养和生物活性分子的机会。文中介绍了用于局部和透皮给药生物活性化合物的各种纳米技术装置。此外,还详细介绍了这些设备可能用于输送营养分子的机制,以及它们有效到达真皮层并促进全身分布的能力。
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来源期刊
CiteScore
22.40
自引率
0.80%
发文量
20
审稿时长
>12 weeks
期刊介绍: Since 2010, the Annual Review of Food Science and Technology has been a key source for current developments in the multidisciplinary field. The covered topics span food microbiology, food-borne pathogens, and fermentation; food engineering, chemistry, biochemistry, rheology, and sensory properties; novel ingredients and nutrigenomics; emerging technologies in food processing and preservation; and applications of biotechnology and nanomaterials in food systems.
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