Bisphenol A (BPA) and neurological disorders: An overview

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-06-27 DOI:10.1016/j.biocel.2024.106614

Sung-Ae Hyun, Minhan Ka

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Abstract

The human body is commonly exposed to bisphenol A (BPA), which is widely used in consumer and industrial products. BPA is an endocrine-disrupting chemical that has adverse effects on human health. In particular, many studies have shown that BPA can cause various neurological disorders by affecting brain development and neural function during prenatal, infancy, childhood, and adulthood exposure. In this review, we discussed the correlation between BPA and neurological disorders based on molecular cell biology, neurophysiology, and behavioral studies of the effects of BPA on brain development and function. Recent studies, both animal and epidemiological, strongly indicate that BPA significantly impacts brain development and function. It hinders neural processes, such as proliferation, migration, and differentiation during development, affecting synaptic formation and activity. As a result, BPA is implicated in neurodevelopmental and neuropsychiatric disorders like autism spectrum disorder (ASD), attention-deficit hyperactivity disorder (ADHD), and schizophrenia.

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双酚 A (BPA) 与神经系统疾病：概述。

人体通常会接触到广泛用于消费品和工业产品的双酚 A（BPA）。双酚 A 是一种干扰内分泌的化学物质，对人体健康有不良影响。特别是，许多研究表明，在产前、婴儿期、儿童期和成年期接触双酚 A 会影响大脑发育和神经功能，从而导致各种神经系统疾病。在这篇综述中，我们基于分子细胞生物学、神经生理学和行为学研究，讨论了双酚 A 对大脑发育和功能影响的相关性。最近的动物学和流行病学研究都强烈表明，双酚 A 会严重影响大脑的发育和功能。它阻碍神经过程，如发育过程中的增殖、迁移和分化，影响突触的形成和活动。因此，双酚 A 与自闭症谱系障碍（ASD）、注意力缺陷多动障碍（ADHD）和精神分裂症等神经发育和神经精神疾病有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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