Enviromental endocrine disruptor risks in the central nervous system: Neurotoxic effects of PFOS and glyphosate

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES Environmental toxicology and pharmacology Pub Date : 2024-07-02 DOI:10.1016/j.etap.2024.104496

Gianluca Antonio Franco , Francesco Molinari , Ylenia Marino , Nicla Tranchida , Francesca Inferrera , Roberta Fusco , Rosanna Di Paola , Rosalia Crupi , Salvatore Cuzzocrea , Enrico Gugliandolo , Domenico Britti

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Abstract

Endocrine disruptors (EDs) pose significant risks to human and environmental health, with potential implications for neurotoxicity. This study investigates the synergistic neurotoxic effects of perfluorooctane sulfonate (PFOS) and glyphosate (GLY), two ubiquitous EDs, using SHSY5Y neuronal and C6 astrocytic cell lines. While individual exposures to PFOS and glyphosate at non-toxic concentrations did not induce significant changes, their combination resulted in a marked increase in oxidative stress and neuroinflammatory responses. Specifically, the co-exposure led to elevated levels of interleukin-6, tumor necrosis factor alpha, and interferon gamma, along with reduced interleukin-10 expression, indicative of heightened neuroinflammatory processes. These findings underscore the importance of considering the synergistic interactions of EDs in assessing neurotoxic risks and highlight the urgent need for further research to mitigate the adverse effects of these compounds on neurological health.

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环境内分泌干扰素在中枢神经系统中的风险：全氟辛烷磺酸和草甘膦的神经毒性效应。

内分泌干扰物（EDs）对人类和环境健康构成重大风险，并对神经毒性产生潜在影响。本研究利用 SHSY5Y 神经元细胞系和 C6 星形胶质细胞系研究了全氟辛烷磺酸（PFOS）和草甘膦（GLY）这两种无处不在的 EDs 的协同神经毒性效应。虽然单独暴露于无毒浓度的全氟辛烷磺酸和草甘膦不会引起显著变化，但两者的结合会导致氧化应激和神经炎症反应明显增加。具体来说，同时暴露会导致白细胞介素-6、肿瘤坏死因子α和γ干扰素水平升高，同时白细胞介素-10的表达减少，这表明神经炎症过程加剧。这些发现强调了在评估神经毒性风险时考虑 EDs 协同作用的重要性，并突出表明迫切需要开展进一步研究，以减轻这些化合物对神经系统健康的不利影响。

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来源期刊

Environmental toxicology and pharmacology 医学-毒理学

CiteScore

7.00

自引率

4.70%

发文量

185

审稿时长

34 days

期刊介绍： Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man. Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxicokinetics (including toxicokinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals. In addition to full length papers, short communications, full-length reviews and mini-reviews, Environmental Toxicology and Pharmacology will publish in depth assessments of special problem areas. The latter publications may exceed the length of a full length paper three to fourfold. A basic requirement is that the assessments are made under the auspices of international groups of leading experts in the fields concerned. The information examined may either consist of data that were already published, or of new data that were obtained within the framework of collaborative research programmes. Provision is also made for the acceptance of minireviews on (classes of) compounds, toxicities or mechanisms, debating recent advances in rapidly developing fields that fall within the scope of the journal.