{"title":"Hot technology and technical evolution of polypeptide nanotechnology in medical application field based on patent data analysis","authors":"Kai Zhao, Tong Wu, Donglin Wei, Hongmei Yuan","doi":"10.1007/s11051-024-06055-7","DOIUrl":null,"url":null,"abstract":"<p>The design of nanostructures based on peptides has attracted wide attention, especially the design of new nanomaterials with higher levels of multifunctional ability is gradually needed. Patent layout allows to identification of related technologies and trends. To reveal the development of global polypeptide nanotechnology in the field of medical application, this paper uses the text mining technology based on patent semantic content to extract the contained knowledge from the patent data set from 1978 to 2023 retrieved from incoPat database and combines the knowledge network with the theme evolution. The hot topics were obtained, and the main technical topics of improving the function of nanomaterials modified by polypeptide were analyzed: the nanointelligent delivery system modified by polypeptide improved the response to stimuli, the transfection rate of gene therapy was improved, the targeting and cell penetration of tumor therapy were improved, the diagnostic sensitivity and biocompatibility were improved, and the detection time of sensors was improved. The research shows that most nanotechnology based on polypeptide is used in medicine to optimize the effect of chemotherapy for tumor treatment. The development of gene therapy is developing rapidly, and technologies such as diagnosis and sensors are emerging, which seems to be very promising. They may hide great potential and represent the field of opportunity research. Most importantly, the technologies related to polypeptide-modified nanostructures are still rapidly developing, and this trend is expected to continue in the next few years.</p>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":null,"pages":null},"PeriodicalIF":2.1000,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Nanoparticle Research","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1007/s11051-024-06055-7","RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
The design of nanostructures based on peptides has attracted wide attention, especially the design of new nanomaterials with higher levels of multifunctional ability is gradually needed. Patent layout allows to identification of related technologies and trends. To reveal the development of global polypeptide nanotechnology in the field of medical application, this paper uses the text mining technology based on patent semantic content to extract the contained knowledge from the patent data set from 1978 to 2023 retrieved from incoPat database and combines the knowledge network with the theme evolution. The hot topics were obtained, and the main technical topics of improving the function of nanomaterials modified by polypeptide were analyzed: the nanointelligent delivery system modified by polypeptide improved the response to stimuli, the transfection rate of gene therapy was improved, the targeting and cell penetration of tumor therapy were improved, the diagnostic sensitivity and biocompatibility were improved, and the detection time of sensors was improved. The research shows that most nanotechnology based on polypeptide is used in medicine to optimize the effect of chemotherapy for tumor treatment. The development of gene therapy is developing rapidly, and technologies such as diagnosis and sensors are emerging, which seems to be very promising. They may hide great potential and represent the field of opportunity research. Most importantly, the technologies related to polypeptide-modified nanostructures are still rapidly developing, and this trend is expected to continue in the next few years.
期刊介绍:
The objective of the Journal of Nanoparticle Research is to disseminate knowledge of the physical, chemical and biological phenomena and processes in structures that have at least one lengthscale ranging from molecular to approximately 100 nm (or submicron in some situations), and exhibit improved and novel properties that are a direct result of their small size.
Nanoparticle research is a key component of nanoscience, nanoengineering and nanotechnology.
The focus of the Journal is on the specific concepts, properties, phenomena, and processes related to particles, tubes, layers, macromolecules, clusters and other finite structures of the nanoscale size range. Synthesis, assembly, transport, reactivity, and stability of such structures are considered. Development of in-situ and ex-situ instrumentation for characterization of nanoparticles and their interfaces should be based on new principles for probing properties and phenomena not well understood at the nanometer scale. Modeling and simulation may include atom-based quantum mechanics; molecular dynamics; single-particle, multi-body and continuum based models; fractals; other methods suitable for modeling particle synthesis, assembling and interaction processes. Realization and application of systems, structures and devices with novel functions obtained via precursor nanoparticles is emphasized. Approaches may include gas-, liquid-, solid-, and vacuum-based processes, size reduction, chemical- and bio-self assembly. Contributions include utilization of nanoparticle systems for enhancing a phenomenon or process and particle assembling into hierarchical structures, as well as formulation and the administration of drugs. Synergistic approaches originating from different disciplines and technologies, and interaction between the research providers and users in this field, are encouraged.