A. D. Khaudov, M. H. Zhekamukhov, A. M. Zaitsev, Z. H. Amshokova, N. V. Berbekova, H. K. Amshokov
{"title":"Analysis of ASIP and MC1R Gene Polymorphisms in Kabardin Horses","authors":"A. D. Khaudov, M. H. Zhekamukhov, A. M. Zaitsev, Z. H. Amshokova, N. V. Berbekova, H. K. Amshokov","doi":"10.3103/s1068367424700010","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>Horses’ coat color has been a subject of interest due to its aesthetic appeal and importance as a criterion for breed identification. Understanding the genetic mechanisms underlying the coat color variations is very important for horse breeders and geneticists. The purpose of the research is to study the effects of polymorphisms of the <i>MC1R</i> and <i>ASIP</i> genes on the coat color of Kabardin horses. The frequencies of occurrence of various alleles and genotypes affecting the equine coat colors and patterns were calculated based on the results of genotyping 127 Kabardin horses for the <i>MC1R</i> and <i>ASIP</i> genes. A statistical analysis was performed to reveal any relationships between them. The Kabardin horses exhibit a diverse array of coat colors, including black-and-bay, black, bay, dark bay, and gray. The majority of the horses surveyed (96.9%) were found to have the dominant allele <i>E</i> of the <i>MC1R</i> gene, associated with the eumelanin synthesis and the darker coat color. The frequency of occurrence of genotype A/A of the <i>ASIP</i> gene tended to increase with the base coat color growing lighter, reaching 0.0, 9.5, 56.6, and 84.8% for black, black-and-bay, dark bay, and bay coat colors, respectively. The mutant allele <i>a</i> frequency made up 0.280. In general, it contributed to the occurrence of the black coat color in Kabardin horses. The outcomes of the research study can contribute to insights into understanding the genetic mechanisms underlying the coat color variations in equine populations.</p>","PeriodicalId":21531,"journal":{"name":"Russian Agricultural Sciences","volume":"26 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Agricultural Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3103/s1068367424700010","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
Horses’ coat color has been a subject of interest due to its aesthetic appeal and importance as a criterion for breed identification. Understanding the genetic mechanisms underlying the coat color variations is very important for horse breeders and geneticists. The purpose of the research is to study the effects of polymorphisms of the MC1R and ASIP genes on the coat color of Kabardin horses. The frequencies of occurrence of various alleles and genotypes affecting the equine coat colors and patterns were calculated based on the results of genotyping 127 Kabardin horses for the MC1R and ASIP genes. A statistical analysis was performed to reveal any relationships between them. The Kabardin horses exhibit a diverse array of coat colors, including black-and-bay, black, bay, dark bay, and gray. The majority of the horses surveyed (96.9%) were found to have the dominant allele E of the MC1R gene, associated with the eumelanin synthesis and the darker coat color. The frequency of occurrence of genotype A/A of the ASIP gene tended to increase with the base coat color growing lighter, reaching 0.0, 9.5, 56.6, and 84.8% for black, black-and-bay, dark bay, and bay coat colors, respectively. The mutant allele a frequency made up 0.280. In general, it contributed to the occurrence of the black coat color in Kabardin horses. The outcomes of the research study can contribute to insights into understanding the genetic mechanisms underlying the coat color variations in equine populations.
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