Shear-thinning Catechol-modified Chitosan Hydrogel Loaded with Silver Nanoparticles for Endoscopic Submucosal Dissection

IF 4.1 2区 化学 Q2 POLYMER SCIENCE Chinese Journal of Polymer Science Pub Date : 2024-06-26 DOI:10.1007/s10118-024-3146-0
Wen-Jun Feng, Yan-He Wu, Xiao-Yang Liu, Zheng-Ke Wang
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Abstract

Shear-thinning hydrogels have emerged for endoscopic submucosal dissection, while wound intervention after surgery has rarely been mentioned. Herein, a catechol-modified chitosan hydrogel with shear-thinning property was developed for simultaneously facilitating endoscopic submucosal dissection and postoperative wound healing. Benefiting from the shear-thinning and self-healing characteristics, the asprepared hydrogel showed easily endoscopic injectability. It also performed very well as submucosal cushion, which could remain above 70% after injection for 120 min in ex vivo porcine large intestine model. In fact, the cushion height of normal saline dramatically decreased to 46% of the initial height at 30 min. Ag nanoparticles encapsulated into the network endowed the hydrogel with almost reached 100% antibacterial effect against E. coli and S. aureus. The hemolysis ratio of the hydrogel was calculated to be as low as 0.8%. Combined with good hemocompatibility and cytocompatibility, the as-prepared hydrogel displayed much higher in vivo wound closure and healing efficacy than normal saline. These results demonstrated the superiority of the shear-thinning chitosan hydrogel in facilitating clinical endoscopic submucosal dissection surgery.

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剪切稀化儿茶酚改性壳聚糖水凝胶载银纳米粒子用于内窥镜粘膜下剥离术
剪切稀化水凝胶已用于内镜粘膜下剥离术,但术后伤口干预却鲜有提及。本文开发了一种具有剪切稀化特性的邻苯二酚改性壳聚糖水凝胶,可同时促进内镜粘膜下剥离和术后伤口愈合。得益于剪切稀化和自愈合特性,所制备的水凝胶易于内窥镜注射。作为粘膜下垫,它的表现也非常出色,在猪大肠体外模型中注射 120 分钟后,粘膜下垫仍能保持在 70% 以上。事实上,正常生理盐水的缓冲高度在 30 分钟后急剧下降至初始高度的 46%。封装在网络中的银纳米粒子使水凝胶对大肠杆菌和金黄色葡萄球菌的抗菌效果几乎达到 100%。据计算,水凝胶的溶血率低至 0.8%。结合良好的血液相容性和细胞相容性,所制备的水凝胶在体内的伤口闭合和愈合效果远远高于生理盐水。这些结果证明了剪切稀化壳聚糖水凝胶在促进临床内镜粘膜下剥离手术方面的优越性。
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来源期刊
Chinese Journal of Polymer Science
Chinese Journal of Polymer Science 化学-高分子科学
CiteScore
7.10
自引率
11.60%
发文量
218
审稿时长
6.0 months
期刊介绍: Chinese Journal of Polymer Science (CJPS) is a monthly journal published in English and sponsored by the Chinese Chemical Society and the Institute of Chemistry, Chinese Academy of Sciences. CJPS is edited by a distinguished Editorial Board headed by Professor Qi-Feng Zhou and supported by an International Advisory Board in which many famous active polymer scientists all over the world are included. The journal was first published in 1983 under the title Polymer Communications and has the current name since 1985. CJPS is a peer-reviewed journal dedicated to the timely publication of original research ideas and results in the field of polymer science. The issues may carry regular papers, rapid communications and notes as well as feature articles. As a leading polymer journal in China published in English, CJPS reflects the new achievements obtained in various laboratories of China, CJPS also includes papers submitted by scientists of different countries and regions outside of China, reflecting the international nature of the journal.
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