Yongwei Hao, Dalin Liu, Kaiyuan Wang, Qian Liu, Hongli Chen, Shenglu Ji, Dan Ding
{"title":"Imaging and Therapy of Tumors Based on Neutrophil Extracellular Traps","authors":"Yongwei Hao, Dalin Liu, Kaiyuan Wang, Qian Liu, Hongli Chen, Shenglu Ji, Dan Ding","doi":"10.1002/smsc.202400212","DOIUrl":null,"url":null,"abstract":"Neutrophil extracellular traps (NETs) formed by neutrophils are netlike scaffolds that mainly contain DNA and a variety of granule proteins. Many stimuli can lead to the NET formation through independent molecular pathways. Clinically, the abundance of NETs is correlated with poor tumor prognosis. The biological actions of NETs are complex and diverse, including promoting tumor progression, awakening the dormant cancer cells, and resulting in immunosuppression in support of tumor growth and metastasis. Therefore, NET-associated pathological processes provide an important clue for both diagnostic imaging and alternative therapies for many kinds of cancers. In recent years, scientists’ efforts have focused on developing novel imaging probes to visualize NETs and therapeutic strategies by degrading NETs or inhibiting its formation to block their pro-tumoral functions. In this review, the development and evaluation of NETs-targeted imaging and intervention progress for tumor therapy are focused on.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"27 1","pages":""},"PeriodicalIF":11.1000,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Small Science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/smsc.202400212","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Neutrophil extracellular traps (NETs) formed by neutrophils are netlike scaffolds that mainly contain DNA and a variety of granule proteins. Many stimuli can lead to the NET formation through independent molecular pathways. Clinically, the abundance of NETs is correlated with poor tumor prognosis. The biological actions of NETs are complex and diverse, including promoting tumor progression, awakening the dormant cancer cells, and resulting in immunosuppression in support of tumor growth and metastasis. Therefore, NET-associated pathological processes provide an important clue for both diagnostic imaging and alternative therapies for many kinds of cancers. In recent years, scientists’ efforts have focused on developing novel imaging probes to visualize NETs and therapeutic strategies by degrading NETs or inhibiting its formation to block their pro-tumoral functions. In this review, the development and evaluation of NETs-targeted imaging and intervention progress for tumor therapy are focused on.
由中性粒细胞形成的中性粒细胞胞外捕获物(NET)是一种网状支架,主要含有 DNA 和多种颗粒蛋白。许多刺激可通过独立的分子途径导致NET的形成。在临床上,NET 的丰富程度与肿瘤的不良预后相关。NETs 的生物作用复杂多样,包括促进肿瘤进展、唤醒休眠癌细胞、导致免疫抑制以支持肿瘤生长和转移。因此,NET相关病理过程为多种癌症的影像诊断和替代疗法提供了重要线索。近年来,科学家们致力于开发新型成像探针来观察NET,以及通过降解NET或抑制其形成来阻断其促瘤功能的治疗策略。在这篇综述中,我们将重点介绍NETs靶向成像的开发和评估,以及肿瘤治疗干预方面的进展。
期刊介绍:
Small Science is a premium multidisciplinary open access journal dedicated to publishing impactful research from all areas of nanoscience and nanotechnology. It features interdisciplinary original research and focused review articles on relevant topics. The journal covers design, characterization, mechanism, technology, and application of micro-/nanoscale structures and systems in various fields including physics, chemistry, materials science, engineering, environmental science, life science, biology, and medicine. It welcomes innovative interdisciplinary research and its readership includes professionals from academia and industry in fields such as chemistry, physics, materials science, biology, engineering, and environmental and analytical science. Small Science is indexed and abstracted in CAS, DOAJ, Clarivate Analytics, ProQuest Central, Publicly Available Content Database, Science Database, SCOPUS, and Web of Science.