Various systemic metabolic diseases arise from prolonged crosstalk across multiple organs, triggering serious impairments in various physiological systems. These diseases are intricate systemic pathologies characterized by complex mechanisms and an unclear etiology, making the treatment challenging. Efforts have been made to develop in vitro models to understand these diseases and devise new treatments. However, there are limitations in reconstructing the causal relationships between diseases and interorgan crosstalk, including the tissue-specific microenvironment. Alternatively, multi-organ microphysiological systems (MOMPS) present new possibilities for capturing the complexity of systemic metabolic diseases by replicating human microphysiology and simulating diverse interorgan crosstalk. Controlled interactions and scalable representations of biological complexity in MOMPS offer a more accurate portrayal of organ interactions, enabling the identification of novel relationships between organ crosstalk, metabolism, and immunity. This, in turn, can yield valuable insights into disease mechanisms and drug development research and enhance the efficiency of preclinical studies. In this review, the examples and technical capabilities of MOMPS pathological modeling for various diseases are discussed, leveraging state-of-the-art biofabrication technology of MOMPS. It evaluates the current opportunities and challenges in this field.
{"title":"Multi-Organ Microphysiological Systems Targeting Specific Organs for Recapitulating Disease Phenotypes via Organ Crosstalk","authors":"Joeng Ju Kim, Mihyeon Bae, Dong-Woo Cho","doi":"10.1002/smsc.202400314","DOIUrl":"https://doi.org/10.1002/smsc.202400314","url":null,"abstract":"Various systemic metabolic diseases arise from prolonged crosstalk across multiple organs, triggering serious impairments in various physiological systems. These diseases are intricate systemic pathologies characterized by complex mechanisms and an unclear etiology, making the treatment challenging. Efforts have been made to develop in vitro models to understand these diseases and devise new treatments. However, there are limitations in reconstructing the causal relationships between diseases and interorgan crosstalk, including the tissue-specific microenvironment. Alternatively, multi-organ microphysiological systems (MOMPS) present new possibilities for capturing the complexity of systemic metabolic diseases by replicating human microphysiology and simulating diverse interorgan crosstalk. Controlled interactions and scalable representations of biological complexity in MOMPS offer a more accurate portrayal of organ interactions, enabling the identification of novel relationships between organ crosstalk, metabolism, and immunity. This, in turn, can yield valuable insights into disease mechanisms and drug development research and enhance the efficiency of preclinical studies. In this review, the examples and technical capabilities of MOMPS pathological modeling for various diseases are discussed, leveraging state-of-the-art biofabrication technology of MOMPS. It evaluates the current opportunities and challenges in this field.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"54 1","pages":""},"PeriodicalIF":12.7,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142253647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wenhua Xue, Jie Chen, Honghao Yao, Jun Mao, Chen Chen, Yumei Wang, Qian Zhang
Zintl phases attract extensive attention due to the characteristic of “electron-crystal, phonon glass”. In this work, an ultralow lattice thermal conductivity ≈0.59 W m−1 K−1 at 300 K and ≈0.3 W m−1 K−1 at 623 K is obtained in CaAgSb Zintl phase, which is much lower than that of other well-known Zintl compounds. The origin of this ultralow lattice thermal conductivity is explored through first-principles calculations and Cs-corrected scanning transmission electron microscopy. Theoretical phonon calculations provide evidence for complex phonon characteristics such as avoided-crossing effect and low-frequency flat band that favor the low lattice thermal conductivity. Moreover, subsequent microstructure results reveal abundant structural defects created in the CaAgSb sample, including superlattice structure and interface structure, which further contribute to the ultralow lattice thermal conductivity.
Zintl 相因其 "电子晶体、声子玻璃 "的特性而受到广泛关注。在这项研究中，CaAgSb Zintl 相在 300 K 时的超低晶格热导率≈0.59 W m-1 K-1，在 623 K 时的超低晶格热导率≈0.3 W m-1 K-1，远低于其他著名的 Zintl 化合物。我们通过第一原理计算和铯校正扫描透射电子显微镜探究了这种超低晶格热导率的来源。理论声子计算证明了声子的复杂特性，如避免交叉效应和低频平带，这有利于实现低晶格热导率。此外，随后的微观结构结果表明，钙银锑样品中存在大量结构缺陷，包括超晶格结构和界面结构，这进一步促进了超低晶格热导率的产生。
{"title":"Ultralow Lattice Thermal Conductivity of Zintl-Phase CaAgSb Induced by Interface and Superlattice Scattering","authors":"Wenhua Xue, Jie Chen, Honghao Yao, Jun Mao, Chen Chen, Yumei Wang, Qian Zhang","doi":"10.1002/smsc.202400147","DOIUrl":"https://doi.org/10.1002/smsc.202400147","url":null,"abstract":"Zintl phases attract extensive attention due to the characteristic of “electron-crystal, phonon glass”. In this work, an ultralow lattice thermal conductivity ≈0.59 W m<sup>−1</sup> K<sup>−1</sup> at 300 K and ≈0.3 W m<sup>−1</sup> K<sup>−1</sup> at 623 K is obtained in CaAgSb Zintl phase, which is much lower than that of other well-known Zintl compounds. The origin of this ultralow lattice thermal conductivity is explored through first-principles calculations and <i>C</i><sub><i>s</i></sub>-corrected scanning transmission electron microscopy. Theoretical phonon calculations provide evidence for complex phonon characteristics such as avoided-crossing effect and low-frequency flat band that favor the low lattice thermal conductivity. Moreover, subsequent microstructure results reveal abundant structural defects created in the CaAgSb sample, including superlattice structure and interface structure, which further contribute to the ultralow lattice thermal conductivity.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"9 1","pages":""},"PeriodicalIF":12.7,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142253648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minhye Kim, Myeongyeon Shin, Yaping Zhao, Mrinmoy Ghosh, Young-Ok Son
Advancing therapeutic progress is centered on developing drug delivery systems (DDS) that control therapeutic molecule release, ensuring precise targeting and optimal concentrations. Targeted DDS enhances treatment efficacy and minimizes off-target effects, but struggles with drug degradation. Over the last three decades, nanopharmaceuticals have evolved from laboratory concepts into clinical products, highlighting the profound impact of nanotechnology in medicine. Despite advancements, the effective delivery of therapeutics remains challenging because of biological barriers. Nanocarriers offer a solution with a small size, high surface-to-volume ratios, and customizable properties. These systems address physiological and biological challenges, such as shear stress, protein adsorption, and quick clearance. They allow targeted delivery to specific tissues, improve treatment outcomes, and reduce adverse effects. Nanocarriers exhibit controlled release, decreased degradation, and enhanced efficacy. Their size facilitates cell membrane penetration and intracellular delivery. Surface modifications increase affinity for specific cell types, allowing precise treatment delivery. This study also elucidates the potential integration of artificial intelligence with nanoscience to innovate future nanocarrier systems.
{"title":"Transformative Impact of Nanocarrier-Mediated Drug Delivery: Overcoming Biological Barriers and Expanding Therapeutic Horizons","authors":"Minhye Kim, Myeongyeon Shin, Yaping Zhao, Mrinmoy Ghosh, Young-Ok Son","doi":"10.1002/smsc.202400280","DOIUrl":"https://doi.org/10.1002/smsc.202400280","url":null,"abstract":"Advancing therapeutic progress is centered on developing drug delivery systems (DDS) that control therapeutic molecule release, ensuring precise targeting and optimal concentrations. Targeted DDS enhances treatment efficacy and minimizes off-target effects, but struggles with drug degradation. Over the last three decades, nanopharmaceuticals have evolved from laboratory concepts into clinical products, highlighting the profound impact of nanotechnology in medicine. Despite advancements, the effective delivery of therapeutics remains challenging because of biological barriers. Nanocarriers offer a solution with a small size, high surface-to-volume ratios, and customizable properties. These systems address physiological and biological challenges, such as shear stress, protein adsorption, and quick clearance. They allow targeted delivery to specific tissues, improve treatment outcomes, and reduce adverse effects. Nanocarriers exhibit controlled release, decreased degradation, and enhanced efficacy. Their size facilitates cell membrane penetration and intracellular delivery. Surface modifications increase affinity for specific cell types, allowing precise treatment delivery. This study also elucidates the potential integration of artificial intelligence with nanoscience to innovate future nanocarrier systems.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"11 1","pages":""},"PeriodicalIF":12.7,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142253654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ho-Jin Moon, Karan Gulati, Tao Li, Corey Stephen Moran, Sašo Ivanovski
Modulating macrophage phenotype based on implant surface characteristics, including topography and chemistry, has been employed to enhance osseointegration and long-term functional outcomes for titanium (Ti)-based implants. An excessive and/or prolonged M1 macrophage response can lead to damaging immune-inflammatory reactions, negatively influencing the fate of the implant, and hence, modulating these responses via nanoscale implant surface modification is an emerging paradigm. Herein, an anodized titanium implant surface based on single-step electrochemical anodization, with preserved underlying microfeatures and superimposed nanopores (50 and 70 nm), compared with irregular rough and microrough (machined-like) surfaces, is investigated for its effect on the functions of primary macrophages in vitro. Significantly reduced macrophage proliferation and increased tissue-reparative M2 phenotype polarization are confirmed for the nanopores, which are more pronounced for 70 nm diameter. Moreover, osteoclastogenesis is reduced while osteogenic differentiation of osteoblasts is enhanced for the nanopores (higher for 70 nm pores). Advanced nanoengineered Ti implants can enhance titanium implant tissue integration by modulating the inflammatory response at the implant–cell interface.
{"title":"Inflammatory or Reparative? Tuning Macrophage Polarization Using Anodized Anisotropic Nanoporous Titanium Implant Surfaces","authors":"Ho-Jin Moon, Karan Gulati, Tao Li, Corey Stephen Moran, Sašo Ivanovski","doi":"10.1002/smsc.202400211","DOIUrl":"https://doi.org/10.1002/smsc.202400211","url":null,"abstract":"Modulating macrophage phenotype based on implant surface characteristics, including topography and chemistry, has been employed to enhance osseointegration and long-term functional outcomes for titanium (Ti)-based implants. An excessive and/or prolonged M1 macrophage response can lead to damaging immune-inflammatory reactions, negatively influencing the fate of the implant, and hence, modulating these responses via nanoscale implant surface modification is an emerging paradigm. Herein, an anodized titanium implant surface based on single-step electrochemical anodization, with preserved underlying microfeatures and superimposed nanopores (50 and 70 nm), compared with irregular rough and microrough (machined-like) surfaces, is investigated for its effect on the functions of primary macrophages in vitro. Significantly reduced macrophage proliferation and increased tissue-reparative M2 phenotype polarization are confirmed for the nanopores, which are more pronounced for 70 nm diameter. Moreover, osteoclastogenesis is reduced while osteogenic differentiation of osteoblasts is enhanced for the nanopores (higher for 70 nm pores). Advanced nanoengineered Ti implants can enhance titanium implant tissue integration by modulating the inflammatory response at the implant–cell interface.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"14 1","pages":""},"PeriodicalIF":12.7,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142253346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yigit Sozen, Gülsüm Ersu, Thomas Pucher, Jorge Quereda, Andres Castellanos-Gomez
Phototransistors are used in plenty of diverse applications such as optical communication systems, light sensors, imaging devices, and biomedical instruments for detecting and amplifying light signals. Herein, an approach for the large-scale production of low-cost and flexible phototransistors by integrating the inks of PEDOT:PSS, and graphite with paper, which serves as an ionic conductor material to gate the PEDOT:PSS channel, is proposed. The fabrication of the devices is carried out by sequentially depositing the PEDOT:PSS channel and graphite electrodes onto paper using a benchtop XY plotter. To characterize device-to-device variability, 200 devices are fabricated and their electrical and optical properties are statistically analyzed. By performing a detailed characterization on the optical properties under varying wavelength, power, and bias conditions, it is found that devices exhibit good photoresponse across a wide spectrum range. Moreover, devices maintain their photoactive characteristics even when subjected to high mechanical tensile strain, indicating the suitability of these paper-supported devices for flexible electronic applications. Time and photocurrent magnitude can be tuned via gate voltages applied through the graphite-based back-gate configuration.
{"title":"Flexible Phototransistors on Paper: Scalable Fabrication of PEDOT:PSS Devices Using a Pen Plotter","authors":"Yigit Sozen, Gülsüm Ersu, Thomas Pucher, Jorge Quereda, Andres Castellanos-Gomez","doi":"10.1002/smsc.202400063","DOIUrl":"https://doi.org/10.1002/smsc.202400063","url":null,"abstract":"Phototransistors are used in plenty of diverse applications such as optical communication systems, light sensors, imaging devices, and biomedical instruments for detecting and amplifying light signals. Herein, an approach for the large-scale production of low-cost and flexible phototransistors by integrating the inks of PEDOT:PSS, and graphite with paper, which serves as an ionic conductor material to gate the PEDOT:PSS channel, is proposed. The fabrication of the devices is carried out by sequentially depositing the PEDOT:PSS channel and graphite electrodes onto paper using a benchtop XY plotter. To characterize device-to-device variability, 200 devices are fabricated and their electrical and optical properties are statistically analyzed. By performing a detailed characterization on the optical properties under varying wavelength, power, and bias conditions, it is found that devices exhibit good photoresponse across a wide spectrum range. Moreover, devices maintain their photoactive characteristics even when subjected to high mechanical tensile strain, indicating the suitability of these paper-supported devices for flexible electronic applications. Time and photocurrent magnitude can be tuned via gate voltages applied through the graphite-based back-gate configuration.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"16 1","pages":""},"PeriodicalIF":12.7,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142253650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ruichao Mao, Jianping Guo, Lihua Bie, Lu-Ning Liu, Jun Gao
In photosynthesis, light energy is absorbed and transferred to the reaction center, ultimately leading to the reduction of quinone molecules through the electron transfer chain. The oxidation and reduction of quinones generate an electrochemical potential difference used for adenosine triphosphate synthesis. The trafficking of quinone/quinol molecules between electron transport components has been a long-standing question. Here, an atomic-level investigation into the molecular mechanism of quinol dissociation in the photosynthetic reaction center–light-harvesting complex 1 (RC–LH1) supercomplexes from Rhodopseudomonas palustris, using classical molecular dynamics (MD) simulations combined with self-random acceleration MD-MD simulations and umbrella sampling methods, is conducted. Results reveal a significant increase in the mobility of quinone molecules upon reduction within RC–LH1, which is accompanied by conformational modifications in the local protein environment. Quinol molecules have a tendency to escape from RC–LH1 in a tail-first mode, exhibiting channel selectivity, with distinct preferred dissociation pathways in the closed and open LH1 rings. Furthermore, comparative analysis of free energy profiles indicates that alternations in the protein environment accelerate the dissociation of quinol molecules through the open LH1 ring. In particular, aromatic amino acids form π-stacking interactions with the quinol headgroup, resembling the key components in a conveyor belt system. This study provides insights into the molecular mechanisms that govern quinone/quinol exchange in bacterial photosynthesis and lays the framework for tuning electron flow and energy conversion to improve metabolic performance.
{"title":"Tunneling Mechanisms of Quinones in Photosynthetic Reaction Center–Light Harvesting 1 Supercomplexes","authors":"Ruichao Mao, Jianping Guo, Lihua Bie, Lu-Ning Liu, Jun Gao","doi":"10.1002/smsc.202400188","DOIUrl":"https://doi.org/10.1002/smsc.202400188","url":null,"abstract":"In photosynthesis, light energy is absorbed and transferred to the reaction center, ultimately leading to the reduction of quinone molecules through the electron transfer chain. The oxidation and reduction of quinones generate an electrochemical potential difference used for adenosine triphosphate synthesis. The trafficking of quinone/quinol molecules between electron transport components has been a long-standing question. Here, an atomic-level investigation into the molecular mechanism of quinol dissociation in the photosynthetic reaction center–light-harvesting complex 1 (RC–LH1) supercomplexes from <i>Rhodopseudomonas palustris</i>, using classical molecular dynamics (MD) simulations combined with self-random acceleration MD-MD simulations and umbrella sampling methods, is conducted. Results reveal a significant increase in the mobility of quinone molecules upon reduction within RC–LH1, which is accompanied by conformational modifications in the local protein environment. Quinol molecules have a tendency to escape from RC–LH1 in a tail-first mode, exhibiting channel selectivity, with distinct preferred dissociation pathways in the closed and open LH1 rings. Furthermore, comparative analysis of free energy profiles indicates that alternations in the protein environment accelerate the dissociation of quinol molecules through the open LH1 ring. In particular, aromatic amino acids form <i>π</i>-stacking interactions with the quinol headgroup, resembling the key components in a conveyor belt system. This study provides insights into the molecular mechanisms that govern quinone/quinol exchange in bacterial photosynthesis and lays the framework for tuning electron flow and energy conversion to improve metabolic performance.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"47 1","pages":""},"PeriodicalIF":12.7,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142253653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mingli Liu, Shuai Liu, Jian Yao, Yu Teng, Lin Geng, Alei Li, Lin Wang, Yunfei Li, Qing Guo, Zongjie Shen, Lixing Kang, Mingsheng Long
In recent years, wide-bandgap semiconductor β-Ga2O3 material has been widely studied because of its excellent properties. Simultaneously, 2D metal oxides (2DMOs) have also become a focus of research owing to their superior stability and unique physical properties arising from quantum confinement effects. Therefore, the exploration of 2D β-Ga2O3 is expected to reveal its novel electrical properties in electronic applications. However, the synthesis of high-quality 2D β-Ga2O3 remains a formidable challenge. Herein, a confined space is constructed to synthesize high-quality 2D β-Ga2O3 nanoflakes by enhancing the control of the kinetics of chemical vapor deposition process. In the device results, it is shown that the grown nanoflakes have excellent switching properties and potential artificial synaptic response characteristics. Based on this premise, an artificial recognition system for handwritten numerals is developed, achieving a peak recognition accuracy of approximately 96%. This system holds significant potential for application within an emerging neuromorphic recognition framework tailored for advanced driver-assistance systems. In this work, a new feasible pathway is provided for the synthesis of 2D non-layered oxides and the potential of 2D oxides in the field of neuroanalog electronics and recognition is shown, thereby advancing the fields of 2D β-Ga2O3 electronics and 2DMOs electronics.
{"title":"Space-Confined Growth of Ultrathin 2D β-Ga2O3 Nanoflakes for Artificial Neuromorphic Application","authors":"Mingli Liu, Shuai Liu, Jian Yao, Yu Teng, Lin Geng, Alei Li, Lin Wang, Yunfei Li, Qing Guo, Zongjie Shen, Lixing Kang, Mingsheng Long","doi":"10.1002/smsc.202400241","DOIUrl":"https://doi.org/10.1002/smsc.202400241","url":null,"abstract":"In recent years, wide-bandgap semiconductor β-Ga<sub>2</sub>O<sub>3</sub> material has been widely studied because of its excellent properties. Simultaneously, 2D metal oxides (2DMOs) have also become a focus of research owing to their superior stability and unique physical properties arising from quantum confinement effects. Therefore, the exploration of 2D β-Ga<sub>2</sub>O<sub>3</sub> is expected to reveal its novel electrical properties in electronic applications. However, the synthesis of high-quality 2D β-Ga<sub>2</sub>O<sub>3</sub> remains a formidable challenge. Herein, a confined space is constructed to synthesize high-quality 2D β-Ga<sub>2</sub>O<sub>3</sub> nanoflakes by enhancing the control of the kinetics of chemical vapor deposition process. In the device results, it is shown that the grown nanoflakes have excellent switching properties and potential artificial synaptic response characteristics. Based on this premise, an artificial recognition system for handwritten numerals is developed, achieving a peak recognition accuracy of approximately 96%. This system holds significant potential for application within an emerging neuromorphic recognition framework tailored for advanced driver-assistance systems. In this work, a new feasible pathway is provided for the synthesis of 2D non-layered oxides and the potential of 2D oxides in the field of neuroanalog electronics and recognition is shown, thereby advancing the fields of 2D β-Ga<sub>2</sub>O<sub>3</sub> electronics and 2DMOs electronics.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"100 1","pages":""},"PeriodicalIF":12.7,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142224587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elisa De Luca, Deborah Pedone, Anna Scarsi, Roberto Marotta, Federico Catalano, Doriana Debellis, Lorenzo Cursi, Benedetto Grimaldi, Mauro Moglianetti, Pier Paolo Pompa
Cellular Imaging
细胞成像
{"title":"Platinum Nanozyme Probes for Cellular Imaging by Electron Microscopy","authors":"Elisa De Luca, Deborah Pedone, Anna Scarsi, Roberto Marotta, Federico Catalano, Doriana Debellis, Lorenzo Cursi, Benedetto Grimaldi, Mauro Moglianetti, Pier Paolo Pompa","doi":"10.1002/smsc.202470035","DOIUrl":"https://doi.org/10.1002/smsc.202470035","url":null,"abstract":"<b>Cellular Imaging</b>","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"33 1","pages":""},"PeriodicalIF":12.7,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142188592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Raïssa Rathar, David Sanchez-Fuentes, Hugo Lachuer, Valentin Meire, Aude Boulay, Rudy Desgarceaux, Fabien P. Blanchet, Adrian Carretero-Genevrier, Laura Picas
Immune Cell Response
免疫细胞反应
{"title":"Tuning the Immune Cell Response through Surface Nanotopography Engineering","authors":"Raïssa Rathar, David Sanchez-Fuentes, Hugo Lachuer, Valentin Meire, Aude Boulay, Rudy Desgarceaux, Fabien P. Blanchet, Adrian Carretero-Genevrier, Laura Picas","doi":"10.1002/smsc.202470038","DOIUrl":"https://doi.org/10.1002/smsc.202470038","url":null,"abstract":"<b>Immune Cell Response</b>","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"20 1","pages":""},"PeriodicalIF":12.7,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142188594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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