Hepatic transcriptomic assessment of Sprague Dawley rats in response to dietary perfluorobutane sulfonate (PFBS) ingestion

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES Environmental toxicology and pharmacology Pub Date : 2024-07-05 DOI:10.1016/j.etap.2024.104497

Isaac Appiah , M. Akpan Ayangaifiok , M. Austin Seymour , P. Corbett Megan , E. Gato Worlanyo

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Abstract

Perfluorobutane sulfonate is a short-chain PFAS that is a less toxic replacement for the rather more toxic long-chain perfluorooctane sulfonate. PFBS is widespread in the environment and has raised environmental and health concerns. The study goal was to investigate whether dietary ingestion of PFBS would induce hepatic damage. Sprague-Dawley rats were assigned to three PFBS treatment groups for 11 weeks followed by clinical markers analyses in the serum and liver. There was a significant increase in liver and body weights of PFBS rats. Total antioxidant capacity was significantly reduced in the PFBS-treated group. ALT levels increased based on concentration ingested. Close to 1000 gene transcripts were differentially expressed. Further, transmembrane transport and oxidation-reduction processes were the most up-regulated biological processes. Inflammatory genes were up-regulated in the exposed group and those associated with oxidative damage were down-regulated. In conclusion, PFBS ingestion produced mild effects in the liver of Sprague Dawley rats.

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斯普拉格道利大鼠肝脏转录组评估对摄入全氟丁烷磺酸盐 (PFBS) 的反应

全氟丁烷磺酸是一种短链全氟辛烷磺酸，是毒性较低的长链全氟辛烷磺酸的替代品。全氟丁烷磺酸在环境中广泛存在，引起了人们对环境和健康的关注。这项研究的目的是调查从膳食中摄入全氟辛烷磺酸是否会诱发肝损伤。研究人员将 Sprague-Dawley 大鼠分为三个 PFBS 处理组，每组 11 周，然后对血清和肝脏中的临床指标进行分析。PFBS大鼠的肝脏和体重明显增加。PFBS 处理组的总抗氧化能力明显降低。ALT水平随摄入浓度的增加而升高。近 1000 个基因转录本出现差异表达。此外，跨膜运输和氧化还原过程是上调最多的生物过程。暴露组的炎症基因上调，而与氧化损伤相关的基因下调。总之，摄入全氟辛烷磺酸会对 Sprague Dawley 大鼠的肝脏产生轻微影响。

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来源期刊

Environmental toxicology and pharmacology 医学-毒理学

CiteScore

7.00

自引率

4.70%

发文量

185

审稿时长

34 days

期刊介绍： Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man. Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxicokinetics (including toxicokinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals. In addition to full length papers, short communications, full-length reviews and mini-reviews, Environmental Toxicology and Pharmacology will publish in depth assessments of special problem areas. The latter publications may exceed the length of a full length paper three to fourfold. A basic requirement is that the assessments are made under the auspices of international groups of leading experts in the fields concerned. The information examined may either consist of data that were already published, or of new data that were obtained within the framework of collaborative research programmes. Provision is also made for the acceptance of minireviews on (classes of) compounds, toxicities or mechanisms, debating recent advances in rapidly developing fields that fall within the scope of the journal.