Partially oxidized polyvinyl alcohol + functionalized water soluble multiwalled carbon nanotubes: A new conductive nanocomposite material with promising implications for neuroregeneration

IF 6.7 3区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Journal of Science: Advanced Materials and Devices Pub Date : 2024-07-02 DOI:10.1016/j.jsamd.2024.100762
Elena Stocco , Silvia Barbon , Ludovica Ceroni , Marta Confalonieri , Giada Pulzato , Samuel Pressi , Alice D'Osualdo , Marta Contran , Rafael Boscolo-Berto , Cesare Tiengo , Silvia Todros , Piero G. Pavan , Veronica Macchi , Raffaele De Caro , Laura Calvillo , Enzo Menna , Andrea Porzionato
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Abstract

Carbon nanotubes (CNT) are promising electroconductive nano-scale materials for neuroregeneration. Herein, we report on a new electroconductive composite scaffold made of the polymer 1% oxidized polyvinyl alcohol (OxPVA) combined with functionalized water soluble multiwalled CNT (OxPVA + MWCNT-S) (diazotization reaction). Preliminarily, MWCNT-S were characterized to evaluate the reaction outcome, the degree of functionalization and the dispersibility in water. Thereafter, OxPVA + MWCNT-S nanocomposite membranes were fabricated and analyzed for physicochemical properties (Raman spectroscopy, thermal decomposition, calorimetric properties, electroconductivity), macroscopic appearance and ultrastructure, mechanical behavior, in vitro cytotoxicity and in vivo biocompatibility. In parallel, OxPVA + MWCNT-S membranes with a linear pattern were also developed and analyzed for interaction with SH-SY5Y cells. Compared to OxPVA, the presence of MWCNT-S (only 0.016 wt%) significantly increased polymer conductivity and imparted a certain porosity without altering mechanical behaviour, as corroborated by uniaxial tensile tests. Neither cytotoxicity nor local signs of inflammation were detected in vitro and after subcutaneous implantation (14 and 42 days), proving composite material biocompatibility. OxPVA + MWCNT-S nanocomposite revealed as promising for future electroconductive conduits free from toxic effects amenable to CNT agglomeration within the polymer. Ideally, nerve lesions with wide gaps, may be effectively supported by those “active” devices, overcoming limitations of the available ones. Despite preliminary data, the presence of a linear pattern confirmed to have a beneficial effect over the scaffold/cells interaction.

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部分氧化聚乙烯醇+功能化水溶性多壁碳纳米管:一种新型导电纳米复合材料,有望用于神经再生
碳纳米管(CNT)是一种很有前景的用于神经再生的纳米级导电材料。在此,我们报告了一种新型导电复合支架,由聚合物 1%氧化聚乙烯醇(OxPVA)与功能化水溶性多壁碳纳米管(OxPVA+MWCNT-S)(重氮化反应)制成。首先,对 MWCNT-S 进行表征,以评估反应结果、功能化程度和在水中的分散性。随后,制备了 OxPVA+MWCNT-S 纳米复合膜,并对其理化性质(拉曼光谱、热分解、量热性质、电导率)、宏观外观和超微结构、机械行为、细胞毒性和生物相容性进行了分析。同时,还开发了线性图案的 OxPVA+MWCNT-S 膜,并分析了其与 SH-SY5Y 细胞的相互作用。单轴拉伸测试证实,与 OxPVA 相比,MWCNT-S(仅 0.016 wt%)的存在显著提高了聚合物的导电性,并在不改变机械性能的情况下赋予其一定的多孔性。皮下植入(14 天和 42 天)后,既未发现细胞毒性,也未发现局部炎症迹象,这证明了复合材料的生物相容性。OxPVA+MWCNT-S纳米复合材料具有良好的前景,可用于未来的导电导管,且不会因CNT在聚合物中聚集而产生毒性效应。理想情况下,这些 "有源 "装置可以有效支持间隙较大的神经损伤,克服现有装置的局限性。尽管有初步数据,但线性模式的存在已证实对支架/细胞的相互作用有好处。
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来源期刊
Journal of Science: Advanced Materials and Devices
Journal of Science: Advanced Materials and Devices Materials Science-Electronic, Optical and Magnetic Materials
CiteScore
11.90
自引率
2.50%
发文量
88
审稿时长
47 days
期刊介绍: In 1985, the Journal of Science was founded as a platform for publishing national and international research papers across various disciplines, including natural sciences, technology, social sciences, and humanities. Over the years, the journal has experienced remarkable growth in terms of quality, size, and scope. Today, it encompasses a diverse range of publications dedicated to academic research. Considering the rapid expansion of materials science, we are pleased to introduce the Journal of Science: Advanced Materials and Devices. This new addition to our journal series offers researchers an exciting opportunity to publish their work on all aspects of materials science and technology within the esteemed Journal of Science. With this development, we aim to revolutionize the way research in materials science is expressed and organized, further strengthening our commitment to promoting outstanding research across various scientific and technological fields.
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