The contribution of cumulative blood pressure load to dementia, cognitive function and mortality in older adults.

IF 4.3 3区 材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-11-01 Epub Date: 2024-07-11 DOI:10.1097/HJH.0000000000003808
Xiaoyue Xu, Vibeke S Catts, Katie Harris, Nelson Wang, Katya Numbers, Julian Trollor, Henry Brodaty, Perminder S Sachdev, Aletta E Schutte
{"title":"The contribution of cumulative blood pressure load to dementia, cognitive function and mortality in older adults.","authors":"Xiaoyue Xu, Vibeke S Catts, Katie Harris, Nelson Wang, Katya Numbers, Julian Trollor, Henry Brodaty, Perminder S Sachdev, Aletta E Schutte","doi":"10.1097/HJH.0000000000003808","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Few studies evaluated the contribution of long-term elevated blood pressure (BP) towards dementia and deaths. We examined the association between cumulative BP (cBP) load and dementia, cognitive decline, all-cause and cardiovascular deaths in older Australians. We also explored whether seated versus standing BP were associated with these outcomes.</p><p><strong>Methods: </strong>The Sydney Memory and Aging Study included 1037 community-dwelling individuals aged 70-90 years, recruited from Sydney, Australia. Baseline data was collected in 2005-2007 and the cohort was followed for seven waves until 2021. cSBP load was calculated as the area under the curve (AUC) for SBP ≥140 mmHg divided by the AUC for all SBP values. Cumulative diastolic BP (cDBP) and pulse pressure (cPP) load were calculated using thresholds of 90 mmHg and 60 mmHg. Cox and mixed linear models were used to assess associations.</p><p><strong>Results: </strong>Of 527 participants with both seated and standing BP data (47.7% men, median age 77), 152 (28.8%) developed dementia over a mean follow-up of 10.5 years. Higher cPP load was associated with a higher risk of all-cause deaths, and cSBP load was associated with a higher risk of cardiovascular deaths in multivariate models ( P for trend < 0.05). Associations between cPP load, dementia and cognitive decline lost statistical significance after adjustment for age. Differences between sitting and standing BP load were not associated with the outcomes.</p><p><strong>Conclusion: </strong>Long-term cPP load was associated with a higher risk of all-cause deaths and cSBP load associated with a higher risk of cardiovascular deaths in older Australians.</p>","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11451970/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Electronic Materials","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/HJH.0000000000003808","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/7/11 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"ENGINEERING, ELECTRICAL & ELECTRONIC","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Few studies evaluated the contribution of long-term elevated blood pressure (BP) towards dementia and deaths. We examined the association between cumulative BP (cBP) load and dementia, cognitive decline, all-cause and cardiovascular deaths in older Australians. We also explored whether seated versus standing BP were associated with these outcomes.

Methods: The Sydney Memory and Aging Study included 1037 community-dwelling individuals aged 70-90 years, recruited from Sydney, Australia. Baseline data was collected in 2005-2007 and the cohort was followed for seven waves until 2021. cSBP load was calculated as the area under the curve (AUC) for SBP ≥140 mmHg divided by the AUC for all SBP values. Cumulative diastolic BP (cDBP) and pulse pressure (cPP) load were calculated using thresholds of 90 mmHg and 60 mmHg. Cox and mixed linear models were used to assess associations.

Results: Of 527 participants with both seated and standing BP data (47.7% men, median age 77), 152 (28.8%) developed dementia over a mean follow-up of 10.5 years. Higher cPP load was associated with a higher risk of all-cause deaths, and cSBP load was associated with a higher risk of cardiovascular deaths in multivariate models ( P for trend < 0.05). Associations between cPP load, dementia and cognitive decline lost statistical significance after adjustment for age. Differences between sitting and standing BP load were not associated with the outcomes.

Conclusion: Long-term cPP load was associated with a higher risk of all-cause deaths and cSBP load associated with a higher risk of cardiovascular deaths in older Australians.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
累积血压负荷对老年人痴呆症、认知功能和死亡率的影响。
背景:很少有研究评估长期血压升高对痴呆症和死亡的影响。我们研究了澳大利亚老年人的累积血压(cBP)负荷与痴呆、认知能力下降、全因和心血管死亡之间的关系。我们还探讨了坐姿血压与站姿血压是否与这些结果有关:悉尼记忆与衰老研究包括从澳大利亚悉尼招募的 1037 名 70-90 岁的社区居民。cSBP 负荷以 SBP≥140 mmHg 的曲线下面积(AUC)除以所有 SBP 值的曲线下面积(AUC)计算。累积舒张压(cDBP)和脉压(cPP)负荷分别以 90 mmHg 和 60 mmHg 为阈值计算。采用 Cox 和混合线性模型评估相关性:在527名有坐位和站立血压数据的参与者(47.7%为男性,中位年龄为77岁)中,有152人(28.8%)在平均10.5年的随访期间患上了痴呆症。在多变量模型中,较高的 cPP 负荷与较高的全因死亡风险相关,而 cSBP 负荷与较高的心血管死亡风险相关(趋势 P < 0.05)。在对年龄进行调整后,cPP负荷与痴呆症和认知能力下降之间的关系失去了统计学意义。坐姿和站姿血压负荷之间的差异与结果无关:结论:在澳大利亚老年人中,长期 cPP 负荷与较高的全因死亡风险有关,而 cSBP 负荷与较高的心血管死亡风险有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
CiteScore
7.20
自引率
4.30%
发文量
567
期刊最新文献
Hyperbaric oxygen treatment promotes tendon-bone interface healing in a rabbit model of rotator cuff tears. Oxygen-ozone therapy for myocardial ischemic stroke and cardiovascular disorders. Comparative study on the anti-inflammatory and protective effects of different oxygen therapy regimens on lipopolysaccharide-induced acute lung injury in mice. Heme oxygenase/carbon monoxide system and development of the heart. Hyperbaric oxygen for moderate-to-severe traumatic brain injury: outcomes 5-8 years after injury.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1