Evaluation of antibiotic resistance changes in Acinetobacter baumannii in the era of COVID-19 in Northern Iran.

IF 1.3 Q4 MICROBIOLOGY Iranian Journal of Microbiology Pub Date : 2024-06-01 DOI:10.18502/ijm.v16i3.15762

Golnar Rahimzadeh, Reza Valadan, Shaghayegh Rezai, Mohammad Khosravi, Laleh Vahedi Larijani, Somayeh Sheidaei, Ebrahim Nemati Hevelaee, Faezeh Sadat Movahedi, Raha Rezai, Mohammad Sadegh Rezai

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Abstract

Background and objectives: During the coronavirus pandemic, the overuse of antibiotics to reduce coinfections and mortality may be contributing to the rise of antimicrobial resistance. In this study, we aim to investigate the antibiotic resistance changes of Acinetobacter baumannii post-COVID-19 pandemic in Northern Iran.

Materials and methods: The current study is a cross-sectional study. Between 2022 and 2023, 2190 clinical samples were collected from patients with healthcare-associated infections (HAIs) at four hospitals in Sari, which served as corona centers after the COVID-19 pandemic. Antimicrobial sensitivity was determined using standard broth macro-dilution, and resistance genes were detected using multiplex PCR.

Results: Based on the results co-amoxiclav had a resistance rate of 100%, while piperacillin/tazobactam showed the least resistance rate of 29.82%. In terms of GM MIC values, colistin was the most potent against multi-drug resistant isolates. The frequency of bla _OXA-51 , ampC, aphA6, and bla _NDM genes were 100%, 99.12%, 90.35%, and 69.30% respectively.

Conclusion: Our study revealed high multi-drug resistance rates. Piperacillin/tazobactam recommended for treating multi-drug resistant Acinetobacter baumannii infections in Northern Iran.

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评估 COVID-19 时代伊朗北部鲍曼不动杆菌的抗生素耐药性变化。

背景和目的：在冠状病毒大流行期间，为减少并发感染和死亡率而过度使用抗生素可能会导致抗生素耐药性的上升。在本研究中，我们旨在调查伊朗北部 COVID-19 大流行后鲍曼不动杆菌的抗生素耐药性变化：本研究为横断面研究。2022 年至 2023 年期间，从 COVID-19 大流行后作为日冕中心的萨里市四家医院的医源性感染（HAI）患者处收集了 2190 份临床样本。使用标准肉汤大稀释法测定抗菌药敏感性，并使用多重 PCR 检测耐药基因：结果显示，共阿莫西林的耐药率为 100%，而哌拉西林/他唑巴坦的耐药率最低，仅为 29.82%。从 GM MIC 值来看，可乐定对耐多药的分离株最有效。bla OXA-51、ampC、aphA6 和 bla NDM 基因的频率分别为 100%、99.12%、90.35% 和 69.30%：结论：我们的研究揭示了较高的多重耐药率。建议在伊朗北部治疗对多种药物耐药的鲍曼不动杆菌感染时使用哌拉西林/他唑巴坦。

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来源期刊

Iranian Journal of Microbiology MICROBIOLOGY-

CiteScore

2.40

自引率

7.10%

发文量

审稿时长

12 weeks

期刊介绍： The Iranian Journal of Microbiology (IJM) is an international, multi-disciplinary, peer-reviewed journal that provides rapid publication of the most advanced scientific research in the areas of basic and applied research on bacteria and other micro-organisms, including bacteria, viruses, yeasts, fungi, microalgae, and protozoa concerning the development of tools for diagnosis and disease control, epidemiology, antimicrobial agents, clinical microbiology, immunology, Genetics, Genomics and Molecular Biology. Contributions may be in the form of original research papers, review articles, short communications, case reports, technical reports, and letters to the Editor. Research findings must be novel and the original data must be available for review by the Editors, if necessary. Studies that are preliminary, of weak originality or merely descriptive as well as negative results are not appropriate for the journal. Papers considered for publication must be unpublished work (except in an abstract form) that is not under consideration for publication anywhere else, and all co-authors should have agreed to the submission. Manuscripts should be written in English.