Pu-erh tea reduces the transmission of CRD-mediated alopecia risk to offspring

IF 7.4 Q1 FOOD SCIENCE & TECHNOLOGY Food frontiers Pub Date : 2024-04-30 DOI:10.1002/fft2.409
Shanshan Hu, Jie Wang, Zhiyuan Lin, Bowen Zhang, Liyong Luo, Liang Zeng
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Abstract

Circadian rhythm disorder (CRD) is closely associated with hair regression and shedding, but whether this risk can be transmitted to the offspring is unknown. Whether Pu-erh tea, with alleviating effects of CRD-mediated syndrome, can act on the transmission of alopecia risk to offspring is also unproven. Here, we obtained CRD parental mice offspring and found that CRD-mediated alopecia risk can be transmitted to offspring, especially male offspring. Parental consumption of Pu-erh tea, especially in females or both parents, reduced the risk of CRD-mediated alopecia transmitted to offspring by inhibiting subcutaneous fat accumulation (downregulation of Rab18, fat-specific protein 27 (Fsp27), and perilipin 1 (Plin1)), reducing oxidative stress and inflammation in skin tissue (NADPH oxidase 4 (NOX4)/ nuclear factor kappa-B (NF-κB)), balancing androgen and hair growth factor release (hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), insulin-like growth factor 1 (IGF-1)), and restoring hair follicle DNA repair function (upregulation of Ku70, 8-Oxoguanine DNA glycosylase 1 (OGG1), and Rad51). Transcriptomic analysis further clarified that the mechanism stemmed from the upregulation of gene expression in pathways such as the Wnt, Hippo, and other signaling pathways.

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普洱茶可降低CRD介导的脱发风险向后代的传递
昼夜节律紊乱(CRD)与毛发退行性脱落密切相关,但这种风险是否会遗传给后代尚不清楚。普洱茶具有缓解昼夜节律紊乱综合征的作用,是否能将脱发风险传递给后代也尚未得到证实。在此,我们获得了 CRD 亲本小鼠的后代,并发现 CRD 介导的脱发风险可传递给后代,尤其是雄性后代。通过抑制皮下脂肪堆积(Rab18、脂肪特异性蛋白27(Fsp27)和过脂素1(Plin1)的下调)、减少皮肤组织的氧化应激和炎症(NADPH氧化酶4(NOX4)/核因子卡巴-B(NF-κB)),父母(尤其是雌性或父母双方)饮用普洱茶可降低CRD介导的脱发遗传给后代的风险、平衡雄激素和毛发生长因子的释放(肝细胞生长因子(HGF)、血管内皮生长因子(VEGF)、胰岛素样生长因子 1(IGF-1)),恢复毛囊 DNA 修复功能(上调 Ku70、8-氧鸟嘌呤 DNA 糖基化酶 1(OGG1)和 Rad51)。转录组分析进一步明确了这一机制源于 Wnt、Hippo 和其他信号通路中基因表达的上调。
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CiteScore
10.50
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审稿时长
10 weeks
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