Exploring the triad: VPS35, neurogenesis, and neurodegenerative diseases

IF 4.2 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of Neurochemistry Pub Date : 2024-07-18 DOI:10.1111/jnc.16184

Zixiong Qiu, Xu Deng, Yuan Fu, Mei Jiang, Xiaojun Cui

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Abstract

Vacuolar protein sorting 35 (VPS35), a critical component of the retromer complex, plays a pivotal role in the pathogenesis of neurodegenerative diseases (NDs). It is involved in protein transmembrane sorting, facilitating the transport from endosomes to the trans-Golgi network (TGN) and plasma membrane. Recent investigations have compellingly associated mutations in the VPS35 gene with neurodegenerative disorders such as Parkinson's and Alzheimer's disease. These genetic alterations are implicated in protein misfolding, disrupted autophagic processes, mitochondrial dysregulation, and synaptic impairment. Furthermore, VPS35 exerts a notable impact on neurogenesis by influencing neuronal functionality, protein conveyance, and synaptic performance. Dysregulation or mutation of VPS35 may escalate the progression of neurodegenerative conditions, underscoring its pivotal role in safeguarding neuronal integrity. This review comprehensively discusses the role of VPS35 and its functional impairments in NDs. Furthermore, we provide an overview of the impact of VPS35 on neurogenesis and further explore the intricate relationship between neurogenesis and NDs. These research advancements offer novel perspectives and valuable insights for identifying potential therapeutic targets in the treatment of NDs.

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探索三要素：VPS35、神经发生和神经退行性疾病。

空泡蛋白分选 35（VPS35）是 retromer 复合物的重要组成部分，在神经退行性疾病（NDs）的发病机制中起着关键作用。它参与蛋白质跨膜分拣，促进从内体到跨高尔基网络（TGN）和质膜的转运。最近的研究发现，VPS35 基因突变与神经退行性疾病（如帕金森氏症和阿尔茨海默氏症）密切相关。这些基因改变与蛋白质错误折叠、自噬过程紊乱、线粒体失调和突触损伤有关。此外，VPS35 通过影响神经元功能、蛋白质传递和突触性能，对神经发生产生显著影响。VPS35 的失调或突变可能会加剧神经退行性疾病的进展，从而凸显其在保护神经元完整性方面的关键作用。本综述全面讨论了 VPS35 在 NDs 中的作用及其功能损伤。此外，我们还概述了 VPS35 对神经发生的影响，并进一步探讨了神经发生与 NDs 之间错综复杂的关系。这些研究进展为确定治疗 NDs 的潜在治疗靶点提供了新的视角和宝贵的见解。

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来源期刊

Journal of Neurochemistry 医学-神经科学

CiteScore

9.30

自引率

2.10%

发文量

181

审稿时长

2.2 months

期刊介绍： Journal of Neurochemistry focuses on molecular, cellular and biochemical aspects of the nervous system, the pathogenesis of neurological disorders and the development of disease specific biomarkers. It is devoted to the prompt publication of original findings of the highest scientific priority and value that provide novel mechanistic insights, represent a clear advance over previous studies and have the potential to generate exciting future research.