{"title":"Alliaceumolide A: A rare undescribed 17-membered macrolide from Indonesian Dysoxylum alliaceum","authors":"Sandra Amalia Riyadi , Al Arofatus Naini , Tri Mayanti , Kindi Farabi , Desi Harneti , Nurlelasari , Rani Maharani , Ronny Lesmana , Sofa Fajriah , Siriporn Jungsuttiwong , Khalijah Awang , Mohamad Nurul Azmi , Unang Supratman","doi":"10.1016/j.phytol.2024.07.004","DOIUrl":null,"url":null,"abstract":"<div><p>Alliaceumolide A (<strong>1</strong>), a new macrolide together with known ivorenolide B (<strong>2</strong>) were isolated from <em>Dysoxylum alliaceum</em> (Blume) Blume ex A.Juss. These compounds were classified as 17-membered macrolide, which is a rare structure for plant-derived natural products. The structures were elucidated by extensive spectroscopic analyses, and the absolute configuration of <strong>1</strong> was determined by electronic circular dichroism (ECD) using TDDFT method. Furthermore, compounds <strong>1</strong> and <strong>2</strong> were tested for cytotoxic activity against two cancer MCF-7 and HeLa cell lines.</p></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"62 ","pages":"Pages 73-77"},"PeriodicalIF":1.3000,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phytochemistry Letters","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1874390024001022","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
Alliaceumolide A (1), a new macrolide together with known ivorenolide B (2) were isolated from Dysoxylum alliaceum (Blume) Blume ex A.Juss. These compounds were classified as 17-membered macrolide, which is a rare structure for plant-derived natural products. The structures were elucidated by extensive spectroscopic analyses, and the absolute configuration of 1 was determined by electronic circular dichroism (ECD) using TDDFT method. Furthermore, compounds 1 and 2 were tested for cytotoxic activity against two cancer MCF-7 and HeLa cell lines.
期刊介绍：
Phytochemistry Letters invites rapid communications on all aspects of natural product research including:
• Structural elucidation of natural products
• Analytical evaluation of herbal medicines
• Clinical efficacy, safety and pharmacovigilance of herbal medicines
• Natural product biosynthesis
• Natural product synthesis and chemical modification
• Natural product metabolism
• Chemical ecology
• Biotechnology
• Bioassay-guided isolation
• Pharmacognosy
• Pharmacology of natural products
• Metabolomics
• Ethnobotany and traditional usage
• Genetics of natural products
Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.
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