Evaluation of the effect of sub-inhibitory concentrations of ceftriaxone on combating multidrug-resistant Staphylococcus aureus

Amira Omar, Tarek Elsaeed Elbanna, Fatma Sonbol, M. El-Bouseary
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Abstract

Staphylococcus aureus is the deadliest of all the common Staphylococcal bacteria and is regarded as one of the most common bacteria that cause illnesses. S. aureus's ability to build biofilms and other virulence variables determines whether it can cause superficial or invasive infections. It can also rapidly alter its virulence and metabolic responses in various tissues. Anti-virulent medications that stop the development of biofilms and virulence factors are therefore becoming increasingly necessary. As a result, we focused on an antibiotic that had already been approved and investigated whether changing the dosage would have an impact on S. aureus virulence. Most of the studied isolates exhibited a noteworthy decrease in S. aureus biofilm and virulence factors production (protease, hemolysin, and coagulase) upon treatment with 1/4 and 1/8 MICs of ceftriaxone, according to the data. It might therefore be regarded as a survival strategy to enhance patient outcomes and reduce germ resistance.
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评价亚抑制浓度头孢曲松对抗耐多药金黄色葡萄球菌的影响
金黄色葡萄球菌是所有常见葡萄球菌中最致命的一种,被认为是最常见的致病细菌之一。金黄色葡萄球菌构建生物膜的能力和其他毒力变量决定了它是能引起表皮感染还是入侵性感染。它还能迅速改变其毒力和各种组织中的代谢反应。因此,阻止生物膜和毒力因子发展的抗病毒药物变得越来越有必要。因此,我们重点研究了一种已获批准的抗生素,并调查了改变剂量是否会对金黄色葡萄球菌的毒力产生影响。数据显示,在使用 1/4、1/8 MICs 的头孢曲松处理后,大多数研究分离菌株的金黄色葡萄球菌生物膜和毒力因子(蛋白酶、溶血素和凝固酶)产生量都有明显下降。因此,可将其视为一种生存策略,以提高患者疗效并降低病菌耐药性。
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