Pub Date : 2024-07-20DOI: 10.21608/jampr.2024.285984.1068
Aalaa Salem, El-Sayed Marwan, Saleh H. El-Sharkawy, Amira Mira
The present study aimed to the in vitro investigation of the ethanol extracts of Washingtonia filifera roots (W.R), barks (W.B), leaves (W.L), fruitless bunches (W.F) and seeds (W.S) for their neuroprotective activities including the phenolic content, antioxidant activity, anti-inflammatory activity and the potentiality to protect mouse neuroblastoma (neuro-2A) cells against H 2 O 2 and A β 1 - 42 -induced neurotoxicity. Among the extracts, W.L and W.F had the highest phenolic content; 226.7 and 172.3 GAE, respectively. Consequently, W.L and W.F showed pronounced DPPH radical scavenging activity with IC 50 values of 19.95 and 30.46 µg/mL, respectively. The highest inhibitory potential of COX-2 was achieved by W.F then W.L with IC 50 values of 111.62 and 191.77 µg/mL. The most efficient extract for the neuroprotection against H 2 O 2 and A β 1 - 42 -induced neurotoxicity was W.F which had more potent activity than the positive control in A β 1 - 42 assay. To the best of our knowledge, this is the first report to indicate the neuroprotective activities of W. filifera leaf and the fruitless bunch extracts.
本研究旨在体外研究华盛顿藤（Washingtonia filifera）根（W.R）、树皮（W.B）、叶（W.L）、无果穗（W.F）和种子（W.S）的乙醇提取物的神经保护活性，包括酚含量、抗氧化活性、抗炎活性以及保护小鼠神经母细胞瘤（neuro-2A）细胞免受 H 2 O 2 和 A β 1 - 42 诱导的神经毒性的潜力。在这些提取物中，W.L 和 W.F 的酚含量最高，分别为 226.7 和 172.3 GAE。因此，W.L 和 W.F 具有明显的 DPPH 自由基清除活性，IC 50 值分别为 19.95 和 30.46 µg/mL。W.F 和 W.L 对 COX-2 的抑制潜力最高，IC 50 值分别为 111.62 和 191.77 µg/mL。W.F 是对 H 2 O 2 和 A β 1 - 42 诱导的神经毒性最有效的神经保护提取物，在 A β 1 - 42 试验中比阳性对照具有更强的活性。据我们所知，这是首次报道丝核果叶和无果束提取物的神经保护活性。
{"title":"Comparative Neuroprotective Activities of the Ethanol Extracts of Washingtonia filifera","authors":"Aalaa Salem, El-Sayed Marwan, Saleh H. El-Sharkawy, Amira Mira","doi":"10.21608/jampr.2024.285984.1068","DOIUrl":"https://doi.org/10.21608/jampr.2024.285984.1068","url":null,"abstract":"The present study aimed to the in vitro investigation of the ethanol extracts of Washingtonia filifera roots (W.R), barks (W.B), leaves (W.L), fruitless bunches (W.F) and seeds (W.S) for their neuroprotective activities including the phenolic content, antioxidant activity, anti-inflammatory activity and the potentiality to protect mouse neuroblastoma (neuro-2A) cells against H 2 O 2 and A β 1 - 42 -induced neurotoxicity. Among the extracts, W.L and W.F had the highest phenolic content; 226.7 and 172.3 GAE, respectively. Consequently, W.L and W.F showed pronounced DPPH radical scavenging activity with IC 50 values of 19.95 and 30.46 µg/mL, respectively. The highest inhibitory potential of COX-2 was achieved by W.F then W.L with IC 50 values of 111.62 and 191.77 µg/mL. The most efficient extract for the neuroprotection against H 2 O 2 and A β 1 - 42 -induced neurotoxicity was W.F which had more potent activity than the positive control in A β 1 - 42 assay. To the best of our knowledge, this is the first report to indicate the neuroprotective activities of W. filifera leaf and the fruitless bunch extracts.","PeriodicalId":130435,"journal":{"name":"Journal of Advanced Medical and Pharmaceutical Research","volume":"117 33","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141820197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-13DOI: 10.21608/jampr.2024.283820.1066
Amira Omar, Tarek Elsaeed Elbanna, Fatma Sonbol, M. El-Bouseary
Staphylococcus aureus is the deadliest of all the common Staphylococcal bacteria and is regarded as one of the most common bacteria that cause illnesses. S. aureus's ability to build biofilms and other virulence variables determines whether it can cause superficial or invasive infections. It can also rapidly alter its virulence and metabolic responses in various tissues. Anti-virulent medications that stop the development of biofilms and virulence factors are therefore becoming increasingly necessary. As a result, we focused on an antibiotic that had already been approved and investigated whether changing the dosage would have an impact on S. aureus virulence. Most of the studied isolates exhibited a noteworthy decrease in S. aureus biofilm and virulence factors production (protease, hemolysin, and coagulase) upon treatment with 1/4 and 1/8 MICs of ceftriaxone, according to the data. It might therefore be regarded as a survival strategy to enhance patient outcomes and reduce germ resistance.
{"title":"Evaluation of the effect of sub-inhibitory concentrations of ceftriaxone on combating multidrug-resistant Staphylococcus aureus","authors":"Amira Omar, Tarek Elsaeed Elbanna, Fatma Sonbol, M. El-Bouseary","doi":"10.21608/jampr.2024.283820.1066","DOIUrl":"https://doi.org/10.21608/jampr.2024.283820.1066","url":null,"abstract":"Staphylococcus aureus is the deadliest of all the common Staphylococcal bacteria and is regarded as one of the most common bacteria that cause illnesses. S. aureus's ability to build biofilms and other virulence variables determines whether it can cause superficial or invasive infections. It can also rapidly alter its virulence and metabolic responses in various tissues. Anti-virulent medications that stop the development of biofilms and virulence factors are therefore becoming increasingly necessary. As a result, we focused on an antibiotic that had already been approved and investigated whether changing the dosage would have an impact on S. aureus virulence. Most of the studied isolates exhibited a noteworthy decrease in S. aureus biofilm and virulence factors production (protease, hemolysin, and coagulase) upon treatment with 1/4 and 1/8 MICs of ceftriaxone, according to the data. It might therefore be regarded as a survival strategy to enhance patient outcomes and reduce germ resistance.","PeriodicalId":130435,"journal":{"name":"Journal of Advanced Medical and Pharmaceutical Research","volume":"27 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141650890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-06DOI: 10.21608/jampr.2024.284952.1067
Amira H. Kamal, M. Mabrouk, Sherin F Hammad, Badiea Soliman
Due to the widespread use of sildenafil, the market is full of different counterfeited preparations that contain either an unknown amount of sildenafil or mixed with one or more different varieties of unknown substances. These fake preparations are usually harmful to users. So, it is always necessary to develop specific as well as sensitive analytical procedures to detect sildenafil in such preparations. HPLC that equipped with modern sensitive detectors such as diode array detector (DAD) can play a great role in solving such problems. In this work, a new HPLC method was established for the detection of sildenafil in some marketed dietary supplements. Thermo scientific ODS HYPERSIL column (250 x 4.6 mm, 5µm) was used. The mobile phase was composed of methanol and potassium di-hydrogen phosphate buffer 0.05M (pH 3.5) at a ratio of 70:30 (v/v). Triethylamine (0.3%) was added to the mobile phase. The flow rate was 1mL/min. Detection was performed at 290 nm using a diode array detector. The method showed good linearity (5.0-80.0 µg/mL). The retention time was 5.3 min. The validation parameters were evaluated as per ICH guidelines. The findings given by the developed method were compared statistically to those achieved by a reported one. There was a good statistical agreement. The developed method is considered a sensitive and specific analytical method for the detection of sildenafil counterfeited dietary supplements.
{"title":"Isocratic RP-HPLC Method for detection of Sildenafil in some Marketed Dietary Supplements","authors":"Amira H. Kamal, M. Mabrouk, Sherin F Hammad, Badiea Soliman","doi":"10.21608/jampr.2024.284952.1067","DOIUrl":"https://doi.org/10.21608/jampr.2024.284952.1067","url":null,"abstract":"Due to the widespread use of sildenafil, the market is full of different counterfeited preparations that contain either an unknown amount of sildenafil or mixed with one or more different varieties of unknown substances. These fake preparations are usually harmful to users. So, it is always necessary to develop specific as well as sensitive analytical procedures to detect sildenafil in such preparations. HPLC that equipped with modern sensitive detectors such as diode array detector (DAD) can play a great role in solving such problems. In this work, a new HPLC method was established for the detection of sildenafil in some marketed dietary supplements. Thermo scientific ODS HYPERSIL column (250 x 4.6 mm, 5µm) was used. The mobile phase was composed of methanol and potassium di-hydrogen phosphate buffer 0.05M (pH 3.5) at a ratio of 70:30 (v/v). Triethylamine (0.3%) was added to the mobile phase. The flow rate was 1mL/min. Detection was performed at 290 nm using a diode array detector. The method showed good linearity (5.0-80.0 µg/mL). The retention time was 5.3 min. The validation parameters were evaluated as per ICH guidelines. The findings given by the developed method were compared statistically to those achieved by a reported one. There was a good statistical agreement. The developed method is considered a sensitive and specific analytical method for the detection of sildenafil counterfeited dietary supplements.","PeriodicalId":130435,"journal":{"name":"Journal of Advanced Medical and Pharmaceutical Research","volume":" 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141672880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-01DOI: 10.21608/jampr.2024.290747.1073
T. Elebyary, Amal Sultan, Sally El-Sayed Abu-Risha, G. E. El Maghraby
Bilosomes are bile salts-containing vesicles that have recently drawn attention as a novel nanocarrier for drugs. Compared to traditional nanocarriers, bilosomes have the advantage of being able to withstand disruption caused by physiological bile salts normally secreted in the gastrointestinal tract. In addition to nonionic surfactants and bile salts, cholesterol is one important ingredient in bilosomes composition. This work investigated the effect of cholesterol concentration on the release rate of the entrapped drug. Tamoxifen was used as a model drug that suffers from poor oral bioavailability due to poor solubility and extensive pre-systemic degradation. Bilosomes composed of Span 60, cholesterol, and bile salts were prepared. Cholesterol was used at two different concentrations of 0.4% and 0.8% w/v, producing formulations BiL1 and BiL2, respectively. The entrapment efficiency and in vitro drug release were evaluated using Franz diffusion cells. Increasing cholesterol concentration reduced drug release. The release efficiency values after 24 hours of release study were 9.7 and 6.8% for BiL1 and BiL2, respectively. This indicates that increasing cholesterol concentration increased the rigidity of the bilosomal membrane and enhanced drug encapsulation. Reduced release would indicate that the vesicles retain the encapsulated drug, which is advantageous, taken into consideration the lymphatic absorption of the vesicles.
{"title":"Effect of formulation variables on drug release from bilosomes; effect of cholesterol concentration","authors":"T. Elebyary, Amal Sultan, Sally El-Sayed Abu-Risha, G. E. El Maghraby","doi":"10.21608/jampr.2024.290747.1073","DOIUrl":"https://doi.org/10.21608/jampr.2024.290747.1073","url":null,"abstract":"Bilosomes are bile salts-containing vesicles that have recently drawn attention as a novel nanocarrier for drugs. Compared to traditional nanocarriers, bilosomes have the advantage of being able to withstand disruption caused by physiological bile salts normally secreted in the gastrointestinal tract. In addition to nonionic surfactants and bile salts, cholesterol is one important ingredient in bilosomes composition. This work investigated the effect of cholesterol concentration on the release rate of the entrapped drug. Tamoxifen was used as a model drug that suffers from poor oral bioavailability due to poor solubility and extensive pre-systemic degradation. Bilosomes composed of Span 60, cholesterol, and bile salts were prepared. Cholesterol was used at two different concentrations of 0.4% and 0.8% w/v, producing formulations BiL1 and BiL2, respectively. The entrapment efficiency and in vitro drug release were evaluated using Franz diffusion cells. Increasing cholesterol concentration reduced drug release. The release efficiency values after 24 hours of release study were 9.7 and 6.8% for BiL1 and BiL2, respectively. This indicates that increasing cholesterol concentration increased the rigidity of the bilosomal membrane and enhanced drug encapsulation. Reduced release would indicate that the vesicles retain the encapsulated drug, which is advantageous, taken into consideration the lymphatic absorption of the vesicles.","PeriodicalId":130435,"journal":{"name":"Journal of Advanced Medical and Pharmaceutical Research","volume":"67 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141276871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives To investigate the relationship between single nucleotide polymorphism (SNP) of excision repair cross-complementation group 1 (ERCC1) rs11615 and the safety outcomes of cisplatin-based adjuvant chemotherapy in post-cystectomy bladder cancer patients. Methods This pilot single-center retrospective cohort research study involved 25 patients with muscle-invasive bladder cancer who were admitted to the Urology and Nephrology Center (UNC), Mansoura University, Egypt between January and December 2016. The study tried to reveal the association between SNP rs11615 in ERCC1 gene and the change from baseline characteristics in a median of 96 weeks follow-up in blood, renal, and hepatic biochemical parameters. Results Univariate analysis of the association between rs11615 and post-chemotherapy changes in uric acid and hemoglobin levels showed a statistically significant relationship. Conclusion These findings hint at possible genetic influences in response to chemotherapy, necessitating further research to understand the mechanisms and potential clinical implications. This could lead to personalized treatment plans enhancing patient care and outcomes.
{"title":"ERCC1 rs11615 Single Nucleotide Polymorphism in Bladder Cancer Patients and Safety Outcomes of Cisplatin-Based Chemotherapy","authors":"Khaled Kotb, Moetaza Soliman, Amira Awadallah, Asmaa Ahmed, Hassan Abol-Enein, Mohamed Shams","doi":"10.21608/jampr.2024.271205.1063","DOIUrl":"https://doi.org/10.21608/jampr.2024.271205.1063","url":null,"abstract":"Objectives To investigate the relationship between single nucleotide polymorphism (SNP) of excision repair cross-complementation group 1 (ERCC1) rs11615 and the safety outcomes of cisplatin-based adjuvant chemotherapy in post-cystectomy bladder cancer patients. Methods This pilot single-center retrospective cohort research study involved 25 patients with muscle-invasive bladder cancer who were admitted to the Urology and Nephrology Center (UNC), Mansoura University, Egypt between January and December 2016. The study tried to reveal the association between SNP rs11615 in ERCC1 gene and the change from baseline characteristics in a median of 96 weeks follow-up in blood, renal, and hepatic biochemical parameters. Results Univariate analysis of the association between rs11615 and post-chemotherapy changes in uric acid and hemoglobin levels showed a statistically significant relationship. Conclusion These findings hint at possible genetic influences in response to chemotherapy, necessitating further research to understand the mechanisms and potential clinical implications. This could lead to personalized treatment plans enhancing patient care and outcomes.","PeriodicalId":130435,"journal":{"name":"Journal of Advanced Medical and Pharmaceutical Research","volume":"78 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140403171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-01DOI: 10.21608/jampr.2024.243076.1060
Mariam Hewala, Sara Abouzeid, Yhiya Amen, Farid Badria
{"title":"Bio-Modulation of Post-Harvested Potato: LC-ESI-MS, GC-MS Analysis, Antioxidant and -amylase Activity of Treated Potato Peels","authors":"Mariam Hewala, Sara Abouzeid, Yhiya Amen, Farid Badria","doi":"10.21608/jampr.2024.243076.1060","DOIUrl":"https://doi.org/10.21608/jampr.2024.243076.1060","url":null,"abstract":"","PeriodicalId":130435,"journal":{"name":"Journal of Advanced Medical and Pharmaceutical Research","volume":"48 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139880845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-01DOI: 10.21608/jampr.2024.243076.1060
Mariam Hewala, Sara Abouzeid, Yhiya Amen, Farid Badria
{"title":"Bio-Modulation of Post-Harvested Potato: LC-ESI-MS, GC-MS Analysis, Antioxidant and -amylase Activity of Treated Potato Peels","authors":"Mariam Hewala, Sara Abouzeid, Yhiya Amen, Farid Badria","doi":"10.21608/jampr.2024.243076.1060","DOIUrl":"https://doi.org/10.21608/jampr.2024.243076.1060","url":null,"abstract":"","PeriodicalId":130435,"journal":{"name":"Journal of Advanced Medical and Pharmaceutical Research","volume":"207 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139820841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-28DOI: 10.21608/jampr.2023.212799.1056
Eman Ezz
The pandemic novel coronavirus disease 2019 (COVID-19) has resulted in enormous economic damage and an exclusive health crisis, so developing a cure for this respiratory infectious disease has proceeded forward at full speed. Natural products and herbal medicines with accepted safety profiles are considered promising sources for discovering new medication leads. Genus Marrubium was reported to exhibit potential antiviral and antioxidant activities. Thus, this study aims to evaluate the inhibitory activity of the total methanolic extract and its soluble fractions: (petroleum ether, methylene chloride, and ethyl acetate) of the aerial parts of Marrubium alysson L . against SARS-CoV-2 main protease (M pro ). Also, they were quantitatively assayed for their phenolics and flavonoids contents, in addition to evaluating their antioxidant activity. The results showed that the petroleum ether fraction has the highest inhibitory activity against SARS-CoV-2 main protease (M pro ) enzyme with IC 50 value of 3.959±0.17 µg/mL compared to the reference tipranavir (IC 50 1.89±0.08 µg/mL). The ethyl acetate fraction showed the highest total phenolics and flavonoids contents as well as the highest antioxidant activity (IC 50 33.81±0.15 µg/mL) compared to the reference L-ascorbic acid (IC 50 30.43±0.14 µg/mL). It could be concluded that soluble fractions of the total methanolic extract of Marrubium alysson L . may be used as an alternative source for developing new natural inhibitors against the main protease enzyme and may be suggested for the treatment of COVID-19.
2019年新型冠状病毒病(COVID-19)造成了巨大的经济损失和独家健康危机，因此开发这种呼吸道传染病的治疗方法正在全速进行。具有公认安全性的天然产品和草药被认为是发现新药物线索的有希望的来源。据报道，Marrubium属具有潜在的抗病毒和抗氧化活性。因此，本研究旨在评价马芦(Marrubium alysson L .)地上部位总甲醇提取物及其可溶性组分(石油醚、二氯甲烷和乙酸乙酯)的抑菌活性。抗SARS-CoV-2主要蛋白酶(M pro)。此外，定量测定了它们的酚类和类黄酮含量，并评估了它们的抗氧化活性。结果表明，石油醚组分对SARS-CoV-2主要蛋白酶(M pro)酶的抑制活性最高，ic50值为3.959±0.17µg/mL，而对照品替那韦的ic50值为1.89±0.08µg/mL。与对照品l -抗坏血酸(ic50为30.43±0.14µg/mL)相比，乙酸乙酯部位的总酚类物质和总黄酮含量最高，抗氧化活性最高(ic50为33.81±0.15µg/mL)。综上所述，马鲁比姆总甲醇提取物的可溶性组分。可作为开发针对主要蛋白酶的新型天然抑制剂的替代来源，并可建议用于治疗COVID-19。
{"title":"Anti-SARS-CoV-2 and Antioxidant Activities of The Methanolic Extract and Its Fractions of Marrubium alysson L. Aerial Parts","authors":"Eman Ezz","doi":"10.21608/jampr.2023.212799.1056","DOIUrl":"https://doi.org/10.21608/jampr.2023.212799.1056","url":null,"abstract":"The pandemic novel coronavirus disease 2019 (COVID-19) has resulted in enormous economic damage and an exclusive health crisis, so developing a cure for this respiratory infectious disease has proceeded forward at full speed. Natural products and herbal medicines with accepted safety profiles are considered promising sources for discovering new medication leads. Genus Marrubium was reported to exhibit potential antiviral and antioxidant activities. Thus, this study aims to evaluate the inhibitory activity of the total methanolic extract and its soluble fractions: (petroleum ether, methylene chloride, and ethyl acetate) of the aerial parts of Marrubium alysson L . against SARS-CoV-2 main protease (M pro ). Also, they were quantitatively assayed for their phenolics and flavonoids contents, in addition to evaluating their antioxidant activity. The results showed that the petroleum ether fraction has the highest inhibitory activity against SARS-CoV-2 main protease (M pro ) enzyme with IC 50 value of 3.959±0.17 µg/mL compared to the reference tipranavir (IC 50 1.89±0.08 µg/mL). The ethyl acetate fraction showed the highest total phenolics and flavonoids contents as well as the highest antioxidant activity (IC 50 33.81±0.15 µg/mL) compared to the reference L-ascorbic acid (IC 50 30.43±0.14 µg/mL). It could be concluded that soluble fractions of the total methanolic extract of Marrubium alysson L . may be used as an alternative source for developing new natural inhibitors against the main protease enzyme and may be suggested for the treatment of COVID-19.","PeriodicalId":130435,"journal":{"name":"Journal of Advanced Medical and Pharmaceutical Research","volume":"21 21","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121003928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-23DOI: 10.21608/jampr.2023.202326.1053
Hosam M El-Seadawy, Kamilia A Abo El-Seoud, Mona El-Aasr, Amany E. Ragab
{"title":"Phytochemical profile, Ethnobotanical and Biological Impacts of Various Zamia Species: A Mini-Review","authors":"Hosam M El-Seadawy, Kamilia A Abo El-Seoud, Mona El-Aasr, Amany E. Ragab","doi":"10.21608/jampr.2023.202326.1053","DOIUrl":"https://doi.org/10.21608/jampr.2023.202326.1053","url":null,"abstract":"","PeriodicalId":130435,"journal":{"name":"Journal of Advanced Medical and Pharmaceutical Research","volume":"149 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127264499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-26DOI: 10.21608/jampr.2023.209199.1055
M. Abdel Hamid, Ahmed A. Habib, M. Mabrouk, Sherin F Hammad, M. Elshahawy
{"title":"Colorimetric Sensor for Determination of Pregabalin Based on Localized Surface Plasmon Resonance of Silver Nanoparticles","authors":"M. Abdel Hamid, Ahmed A. Habib, M. Mabrouk, Sherin F Hammad, M. Elshahawy","doi":"10.21608/jampr.2023.209199.1055","DOIUrl":"https://doi.org/10.21608/jampr.2023.209199.1055","url":null,"abstract":"","PeriodicalId":130435,"journal":{"name":"Journal of Advanced Medical and Pharmaceutical Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126100276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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