Evaluation of some biomarkers (phosphorus, Parathyroid hormone, Calcium, vitamin D) in patient's serum with chronic kidney disease (CKD)

Abstract

Background chronic kidney disease (CKD) can be defined as abnormalities either in kidney structure or function by decreasing glomerular filtration rate (GFR) of less than 60 mL/min/1.73 m² for at least 3 months. it is considered to be a major medical problem, especially in developing countries and emerging economies. The study aims to measure biochemical markers (calcium, phosphorus, vitamin D, and PTH) in patients with CKD and healthy control, also finding out the effect of CKD on formation active form of vitamin D. Methods: This study includes (90) individuals (60) patients (30 males and 30 females) and (30) healthy control. The criteria of inclusion were: patients previously diagnosed with chronic kidney disease, In the study population age ranged between ( 30-70) years old for both groups who visited Al-Basra General Hospital in the province of Basra (The National Hemodialysis Project, artificial kidney Center) through period from November 2022 to February 2023.VIDAS was used to measure parathyroid hormone and vitamin D, while COBAS C111 was used to measure serum phosphorus and calcium levels, for both patients and healthy control groups. The results of the current study have shown that there was a high significant increase (P < 0.001) in the levels following biomarkers in CKD patients: PTH and phosphorus, the results also showed that a significant decrease was recorded in levels following biomarkers in CKD patients: serum calcium and vitamin D. There was also a positive relationship between the levels of calcium in patients with CKD and vitamin D while it was recorded that there was a negative relationship between the level of vitamin D with phosphorus and parathyroid hormone levels. In conclusion, the results of the current study have shown that there was a highly significant increase in PTH and phosphorus and a significant decrease in levels of serum calcium and vitamin D.