The challenge of generating lasting mucosal anti-viral sterilising immunity

Abstract

Achieving sterilising immunity is often challenging and sometimes even impossible. This article gives a glimpse into the concepts behind and highlights some recent advances and challenges. In its essence, sterilising immunity describes the removal of a virus from the host before it can replicate, and this kind of immunity would be the preferred outcome for vaccination as it efficiently limits the infection of the individual and the spread of disease within the community. A typical viral infection goes through a four-step cycle: first, the virus attaches to and enters a host cell; second, it copies its genetic material; third, it assembles new viral particles; and finally, it detaches to infect new cells. In its most straightforward form, sterilising immunity is achieved by the neutralisation of the infectious potential in the first step, (Wahl and Wardemann, Immunity, 2022) followed by their removal.