Functional regulation of hydroxyproline, ascorbic acid and lipid peroxidation during GABA chitosan nanoparticles mediated liver regeneration

Abstract

BACKGROUND: Liver is a vital organ and the role of Gamma aminobutyric acid (GABA) conjugated chitosan nanoparticles in enhancing the hepatocyte proliferation was reported. To understand the influence of these nanoparticles on various biochemical parameters during enhanced liver regeneration will improve its clinical significance. OBJECTIVE: To highlight the influence of GABA chitosan nanoparticles on ascorbic acid, hydroxyproline and lipid peroxidation levels during liver regeneration. METHODS: Intraperitoneal administration of nanoparticles was done to partially hepatectomised female Sprague Dawley rats (GCNP) and compared the biochemical parameters with sham operated control (C) and with no treatment (PHNT) cases. RESULTS: The hydroxyproline content was increased in the liver of GCNP when compared to PHNT (P < 0.05). The lipid peroxidation level was increased (P < 0.01) in PHNT compared to the control whereas, decreased in GCNP when compared (P < 0.01) with PHNT. There was a significant increase (P < 0.01) in the ascorbic acid content in PHNT when compared with C. It was significantly decreased (P < 0.01) in GCNP when compared with PHNT. CONCLUSION: This highlighted the therapeutic implications of lipid peroxidation, hydroxyproline and ascorbic acid in GABA chitosan nanoparticles mediated liver regeneration, which will have immense clinical relevance in maintaining liver health.