Pathogenesis and Oral-Related Factors in Post-COVID-19 Mucormycosis Patients: A Protocol for a Systematic Review of Case Reports

Abstract

During the COVID-19 pandemic, there was a notable increase in cases of oral mucormycosis, with some researchers linking corticosteroid treatment to immune suppression, potentially increasing susceptibility to this fungal infection. Early oral manifestations may serve as indicators for timely diagnosis. This protocol for a systematic review aims to elucidate the pathogenesis and related factors of post-COVID-19 mucormycosis through the analysis of case reports. We will conduct a comprehensive search of relevant articles, excluding review articles and case series. Bias risk will be assessed using the ROBINS-E tool, and certainty of evidence will be evaluated using the GRADE framework. A narrative synthesis of the data will be performed, focusing on sociodemographic profiles, medical and family histories, diagnostic methods, treatment approaches, and dental relevance.