Zifeng Wang, Xiangyu Wang, Shenghang Xu, Dingxin Liu, Jingyao Zhang, Qiuyi Yue, Luge Wang, Pengfei Zhang, Yikang Jia, Jishen Zhang, Li Guo, Dandan Pei, Chang Liu and Mingzhe Rong
{"title":"Upgrading the production of plasma-activated water for sterilization by preloading long-lived reactive species","authors":"Zifeng Wang, Xiangyu Wang, Shenghang Xu, Dingxin Liu, Jingyao Zhang, Qiuyi Yue, Luge Wang, Pengfei Zhang, Yikang Jia, Jishen Zhang, Li Guo, Dandan Pei, Chang Liu and Mingzhe Rong","doi":"10.1088/1361-6463/ad60d9","DOIUrl":null,"url":null,"abstract":"Plasma-activated water (PAW) has broad prospects in the medical field because it is rich in reactive nitrogen and oxygen species. However, in most production processes of PAW, a large proportion of gaseous reactive species is converted into long-lived aqueous species with minor biochemical activity, and only a small proportion is converted into crucial short-lived aqueous species, which results in inefficient activation of PAW. Given the indispensability and easy availability of long-lived aqueous species, this study proposes to preload HNO3 and H2O2 into water and then generate plasma to induce short-lived aqueous species, thus improving the production rate of PAW. The addition of 1 mM HNO3 and 0.5% H2O2 results in a 100-fold increase in the production rate of the PAW with a bactericidal rate exceeding 99.9999%, and the preloaded HNO3 and H2O2 promote the dissolution of O3 and the generation of short-lived aqueous species, respectively. Moreover, the preloaded species improve the validity period of PAW and the resistance of sterilization to acid-base neutralizers. This study offers a novel approach for upgrading the production of PAW, which holds promise for realizing rapid PAW production with a portable device for clinical medical applications.","PeriodicalId":16789,"journal":{"name":"Journal of Physics D: Applied Physics","volume":null,"pages":null},"PeriodicalIF":3.1000,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Physics D: Applied Physics","FirstCategoryId":"101","ListUrlMain":"https://doi.org/10.1088/1361-6463/ad60d9","RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHYSICS, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
Plasma-activated water (PAW) has broad prospects in the medical field because it is rich in reactive nitrogen and oxygen species. However, in most production processes of PAW, a large proportion of gaseous reactive species is converted into long-lived aqueous species with minor biochemical activity, and only a small proportion is converted into crucial short-lived aqueous species, which results in inefficient activation of PAW. Given the indispensability and easy availability of long-lived aqueous species, this study proposes to preload HNO3 and H2O2 into water and then generate plasma to induce short-lived aqueous species, thus improving the production rate of PAW. The addition of 1 mM HNO3 and 0.5% H2O2 results in a 100-fold increase in the production rate of the PAW with a bactericidal rate exceeding 99.9999%, and the preloaded HNO3 and H2O2 promote the dissolution of O3 and the generation of short-lived aqueous species, respectively. Moreover, the preloaded species improve the validity period of PAW and the resistance of sterilization to acid-base neutralizers. This study offers a novel approach for upgrading the production of PAW, which holds promise for realizing rapid PAW production with a portable device for clinical medical applications.
期刊介绍:
This journal is concerned with all aspects of applied physics research, from biophysics, magnetism, plasmas and semiconductors to the structure and properties of matter.