The timing of sleep spindles is modulated by the respiratory cycle in humans

IF 3.7 3区 医学 Q1 CLINICAL NEUROLOGY Clinical Neurophysiology Pub Date : 2024-07-09 DOI:10.1016/j.clinph.2024.06.014
Valentin Ghibaudo , Maxime Juventin , Nathalie Buonviso , Laure Peter-Derex
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Abstract

Objective

Coupling of sleep spindles with cortical slow waves and hippocampus sharp-waves ripples is crucial for sleep-related memory consolidation. Recent literature evidenced that nasal respiration modulates neural activity in large-scale brain networks. In rodents, this respiratory drive strongly varies according to vigilance states. Whether sleep oscillations are also respiration-modulated in humans remains open. In this work, we investigated the influence of breathing on sleep spindles during non-rapid-eye-movement sleep in humans.

Methods

Full night polysomnography of twenty healthy participants were analysed. Spindles and slow waves were automatically detected during N2 and N3 stages. Spindle-related sigma power as well as spindle and slow wave events were analysed according to the respiratory phase.

Results

We found a significant coupling between both slow and fast spindles and the respiration cycle, with enhanced sigma activity and occurrence probability of spindles during the middle part of the expiration phase. A different coupling was observed for slow waves negative peaks which were rather distributed around the two respiration phase transitions.

Conclusion

Our findings suggest that breathing cycle influences the dynamics of brain activity during non-rapid-eye-movement sleep.

Significance

This coupling may enable sleep spindles to synchronize with other sleep oscillations and facilitate information transfer between distributed brain networks.

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睡眠棘波的时间受人类呼吸周期的调节。
目的睡眠棘波与大脑皮层慢波和海马锐波波纹的耦合对于与睡眠相关的记忆巩固至关重要。最近的文献证明,鼻腔呼吸可调节大规模大脑网络中的神经活动。在啮齿类动物中,这种呼吸驱动力随警觉状态的不同而强烈变化。在人类中,睡眠振荡是否也受呼吸调节的影响仍是未知数。在这项工作中,我们研究了人类非快速眼动睡眠期间呼吸对睡眠棘波的影响:方法:分析了 20 名健康参与者的整夜多导睡眠图。在 N2 和 N3 阶段自动检测主旋和慢波。根据呼吸阶段分析与纺锤体相关的σ功率以及纺锤体和慢波事件:结果:我们发现慢速和快速纺锤体与呼吸周期之间存在明显的耦合关系,在呼气阶段的中间部分,σ活动增强,纺锤体出现的概率增加。慢波负峰的耦合则有所不同,它们主要分布在两个呼吸相位的转换处:我们的研究结果表明,呼吸周期会影响非快速眼动睡眠时大脑活动的动态:这种耦合可能使睡眠棘波与其他睡眠振荡同步,并促进分布式大脑网络之间的信息传递。
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来源期刊
Clinical Neurophysiology
Clinical Neurophysiology 医学-临床神经学
CiteScore
8.70
自引率
6.40%
发文量
932
审稿时长
59 days
期刊介绍: As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.
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