Optimizing the identification of long-interval intracortical inhibition from the dorsolateral prefrontal cortex.

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY Clinical Neurophysiology Pub Date : 2024-11-16 DOI:10.1016/j.clinph.2024.10.018

Mayuko Takano, Masataka Wada, Shinichiro Nakajima, Keita Taniguchi, Shiori Honda, Yu Mimura, Ryosuke Kitahata, Reza Zomorrodi, Daniel M Blumberger, Zafiris J Daskalakis, Hiroyuki Uchida, Masaru Mimura, Yoshihiro Noda

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Abstract

Objective: This study aimed to optimally evaluate the effect of the long-interval intracortical inhibition (LICI) in the dorsolateral prefrontal cortex (DLPFC) through transcranial magnetic stimulation combined with electroencephalography (TMS-EEG) by eliminating the volume conductance with signal source estimation and using a realistic sham coil as a control.

Methods: We compared the LICI effects from the DLPFC between the active and sham stimulation conditions in 27 healthy participants. Evoked responses between the two conditions were evaluated at the sensor and source levels.

Results: At the sensor level, a significant LICI effect was confirmed in the active condition in the global mean field power analysis; however, in the local mean field power analysis focused on the DLPFC, no LICI effect was observed in the active condition. However, in the signal source estimation analysis for the DLPFC, we could reconfirm a significant LICI effect (p = 0.023) in the interval 30-250 ms post-stimulus, compared to the sham condition.

Conclusions: Our results demonstrate that application of realistic sham stimulation condition and source estimation method allows for a robust and optimal identification of the LICI effect in the DLPFC.

Significance: The optimal DLPFC-LICI effect was identified by the use of the sophisticated sham coil.

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优化背外侧前额叶皮层对长间隔皮层内抑制的识别。

研究目的本研究旨在通过经颅磁刺激结合脑电图（TMS-EEG），利用信号源估计消除体积传导，并使用真实的假线圈作为对照，以最佳方式评估皮层内长间隔抑制（LICI）在背外侧前额叶皮层（DLPFC）中的效果：我们比较了 27 名健康参与者在主动刺激和假刺激条件下 DLPFC 的 LICI 效果。我们在传感器和信号源层面评估了两种刺激条件下的诱发反应：结果：在传感器层面，全局平均场功率分析证实在主动条件下存在显著的LICI效应；然而，在以DLPFC为重点的局部平均场功率分析中，主动条件下未观察到LICI效应。然而，在对DLPFC进行信号源估计分析时，我们再次证实，与假刺激条件相比，在刺激后30-250毫秒区间内存在显著的LICI效应（p = 0.023）：结论：我们的研究结果表明，应用真实的假刺激条件和源估计方法可以对 DLPFC 的 LICI 效应进行稳健而优化的识别：意义：通过使用复杂的假线圈，可以识别出最佳的DLPFC-LICI效应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.