Delivering Microrobots in the Musculoskeletal System

IF 26.6 1区 材料科学 Q1 Engineering Nano-Micro Letters Pub Date : 2024-07-22 DOI:10.1007/s40820-024-01464-8
Mumin Cao, Renwang Sheng, Yimin Sun, Ying Cao, Hao Wang, Ming Zhang, Yunmeng Pu, Yucheng Gao, Yuanwei Zhang, Panpan Lu, Gaojun Teng, Qianqian Wang, Yunfeng Rui
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Abstract

Highlights

  • A systematic review of recent advances of microrobots applied in the musculoskeletal system with an emphasis on design strategies of microrobotic systems for tissue regeneration.

  • The fabrication, motion and control, and image-guided delivery of microrobots in the musculoskeletal system are reviewed based on the up-to-date works.

  • Prospects and challenges for future clinical translation of microrobots in the musculoskeletal system and regenerative medicine are discussed.

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在肌肉骨骼系统中输送微型机器人。
肌肉骨骼系统疾病是造成全球疾病负担的主要因素,而目前的治疗方法疗效有限。患者经常遭受慢性疼痛的折磨,最终可能不得不接受终末期手术。因此,未来的治疗应侧重于早期发现和干预区域病变。微型机器人具有智能、精确和微创靶向给药的优势,已逐渐应用于生物体内。通过与控制系统和成像系统的结合,具有良好生物安全性的微机器人可被输送到所需的区域进行治疗。在肌肉骨骼系统中,微机器人主要用于运送干细胞/药物或清除体内有害物质。与传统的生物材料和组织工程策略相比,主动运动提高了细胞/药物局部靶向的效率和穿透力。本综述讨论了微机器人系统在肌肉骨骼系统不同组织中的前沿应用。通过评估不同微型机器人的特点,我们总结了阻碍临床转化的挑战和障碍,最后指出了微型机器人在肌肉骨骼系统中的未来发展方向。
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来源期刊
Nano-Micro Letters
Nano-Micro Letters NANOSCIENCE & NANOTECHNOLOGY-MATERIALS SCIENCE, MULTIDISCIPLINARY
CiteScore
32.60
自引率
4.90%
发文量
981
审稿时长
1.1 months
期刊介绍: Nano-Micro Letters is a peer-reviewed, international, interdisciplinary, and open-access journal published under the SpringerOpen brand. Nano-Micro Letters focuses on the science, experiments, engineering, technologies, and applications of nano- or microscale structures and systems in various fields such as physics, chemistry, biology, material science, and pharmacy.It also explores the expanding interfaces between these fields. Nano-Micro Letters particularly emphasizes the bottom-up approach in the length scale from nano to micro. This approach is crucial for achieving industrial applications in nanotechnology, as it involves the assembly, modification, and control of nanostructures on a microscale.
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