Large-scale study of blood markers in equine atypical myopathy reveals subclinical poisoning and advances in diagnostic and prognostic criteria

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES Environmental toxicology and pharmacology Pub Date : 2024-07-18 DOI:10.1016/j.etap.2024.104515

Benoît Renaud , Caroline-J. Kruse , Anne-Christine François , Carla Cesarini , Gunther van Loon , Katrien Palmers , François Boemer , Géraldine Luis , Pascal Gustin , Dominique-Marie Votion

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Abstract

Equine atypical myopathy (AM) is a severe rhabdomyolysis syndrome primarily caused by hypoglycin A (HGA) and methylenecyclopropylglycine protoxins. This study aimed to refine diagnostic and prognostic criteria for AM while exploring apparently healthy cograzers. Blood samples from 263 horses, including AM cases (n= 95), cograzers (n= 73), colic horses (n= 19), and controls (n= 76), were analyzed for HGA, its toxic metabolite, and acylcarnitines profile. Diseased horses exhibited alterations in acylcarnitines that strongly distinguished them from controls and colic horses. Regression analyses identified distinct acylcarnitines profiles among groups, with cograzers showing intermediate alterations. Age and gelding status emerged as protective factors against AM. Furthermore, serum acylcarnitines profiling was valuable in predicting AM survival, with isovaleryl-/2-methylbutyrylcarnitine (i.e., C5 acylcarnitine) showing promise as both a diagnostic and prognostic marker. Subclinical alterations in cograzers underscore a novel aspect: the presence of subclinical cases of AM.

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对马非典型肌病血液标记物的大规模研究揭示了亚临床中毒以及诊断和预后标准的进展。

马非典型肌病（AM）是一种严重的横纹肌溶解综合征，主要由低甘氨酸 A（HGA）和亚甲基环丙基甘氨酸原毒素引起。本研究旨在完善 AM 的诊断和预后标准，同时探索表面上健康的马匹。研究人员对 263 匹马的血液样本进行了 HGA、其毒性代谢物和酰基肉碱谱分析，其中包括 AM 病例（95 匹）、cograzers（73 匹）、肠绞痛马（19 匹）和对照组（76 匹）。患病马的酰基肉碱发生了变化，与对照组和肠绞痛马有明显区别。回归分析确定了各组之间不同的酰基肉碱谱，其中阉马的变化介于两者之间。年龄和阉割状态是防止急性髓系白血病的保护因素。此外，血清酰基肉碱谱分析对预测急性髓系白血病的存活率很有价值，其中异戊酰-/2-甲基丁酰肉碱（即 C5酰基肉碱）有望成为诊断和预后标志物。cograzers的亚临床改变强调了一个新的方面：AM亚临床病例的存在。

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来源期刊

Environmental toxicology and pharmacology 医学-毒理学

CiteScore

7.00

自引率

4.70%

发文量

185

审稿时长

34 days

期刊介绍： Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man. Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxicokinetics (including toxicokinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals. In addition to full length papers, short communications, full-length reviews and mini-reviews, Environmental Toxicology and Pharmacology will publish in depth assessments of special problem areas. The latter publications may exceed the length of a full length paper three to fourfold. A basic requirement is that the assessments are made under the auspices of international groups of leading experts in the fields concerned. The information examined may either consist of data that were already published, or of new data that were obtained within the framework of collaborative research programmes. Provision is also made for the acceptance of minireviews on (classes of) compounds, toxicities or mechanisms, debating recent advances in rapidly developing fields that fall within the scope of the journal.