Prevalence and prognostic role of thoracic lymphadenopathy in Covid-19.

IF 1.3 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Rofo-fortschritte Auf Dem Gebiet Der Rontgenstrahlen Und Der Bildgebenden Verfahren Pub Date : 2025-02-01 Epub Date: 2024-07-22 DOI:10.1055/a-2293-8132

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Abstract

Purpose: The prevalent coronavirus disease 2019 (COVID-19) pandemic has spread throughout the world and is considered a serious threat to global health. The prognostic role of thoracic lymphadenopathy in COVID-19 is unclear. The aim of the present meta-analysis was to analyze the prognostic role of thoracic lymphadenopathy for the prediction of 30-day mortality in patients with COVID-19.

Materials and methods: The MEDLINE library, Cochrane, and SCOPUS databases were screened for associations between CT-defined features and mortality in COVID-19 patients up to June 2021. In total, 21 studies were included in the present analysis. The quality of the included studies was assessed by the Newcastle-Ottawa Scale. The meta-analysis was performed using RevMan 5.3. Heterogeneity was calculated by means of the inconsistency index I2. DerSimonian and Laird random-effect models with inverse variance weights were performed without any further correction.

Results: The included studies comprised 4621 patients. The prevalence of thoracic lymphadenopathy varied between 1 % and 73.4 %. The pooled prevalence was 16.7 %, 95 % CI = (15.6 %; 17.8 %). The hospital mortality was higher in patients with thoracic lymphadenopathy (34.7 %) than in patients without (20.0 %). The pooled odds ratio for the influence of thoracic lymphadenopathy on mortality was 2.13 (95 % CI = [1.80-2.52], p < 0.001).

Conclusion: The prevalence of thoracic lymphadenopathy in COVID-19 is 16.7 %. The presence of thoracic lymphadenopathy is associated with an approximately twofold increase in the risk for hospital mortality in COVID-19.

Key points: · The prevalence of lymphadenopathy in COVID-19 is 16.7 %.. · Patients with lymphadenopathy in COVID-19 have a higher risk of mortality during hospitalization.. · Lymphadenopathy nearly doubles mortality and plays an important prognostic role..

Citation format: · Bucher AM, Sieren M, Meinel F et al. Prevalence and prognostic role of thoracic lymphadenopathy in Covid-19. Rofo 2025; 197: 163 - 171.

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胸部淋巴结病在 Covid-19 中的发病率和预后作用。

目的：流行性冠状病毒病 2019（COVID-19）大流行已蔓延至世界各地，被认为是对全球健康的严重威胁。胸腔淋巴结病在 COVID-19 中的预后作用尚不明确。本荟萃分析旨在分析胸部淋巴结病在预测 COVID-19 患者 30 天死亡率方面的预后作用：筛选了MEDLINE图书馆、Cochrane和SCOPUS数据库中截至2021年6月COVID-19患者的CT定义特征与死亡率之间的关系。本分析共纳入 21 项研究。纳入研究的质量采用纽卡斯尔-渥太华量表进行评估。荟萃分析使用 RevMan 5.3 进行。异质性通过不一致指数 I2 进行计算。使用反方差权重的 DerSimonian 和 Laird 随机效应模型进行分析，无需进一步校正：结果：纳入的研究包括 4621 名患者。胸部淋巴结病的发病率介于 1% 和 73.4% 之间。汇总患病率为 16.7%，95% CI = (15.6%; 17.8%)。胸腔淋巴结病患者的住院死亡率（34.7%）高于无胸腔淋巴结病患者（20.0%）。胸腔淋巴结病对死亡率影响的合计几率比为 2.13（95 % CI = [1.80-2.52]，p 结论：胸腔淋巴结病的发病率与死亡率之间存在显著相关性：在 COVID-19 中，胸部淋巴结病的发病率为 16.7%。在 COVID-19 中，胸腔淋巴结病的存在与住院死亡率风险增加约两倍有关：- COVID-19中淋巴结病的发病率为16.7%。- COVID-19中患有淋巴腺病的患者在住院期间的死亡风险较高。- 淋巴结病几乎使死亡率增加一倍，对预后起着重要作用：- Bucher AM, Sieren M, Meinel F et al.Covid-19胸腔淋巴结病的患病率和预后作用。Fortschr Röntgenstr 2024; DOI: 10.1055/a-2293-8132.

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Rofo-fortschritte Auf Dem Gebiet Der Rontgenstrahlen Und Der Bildgebenden Verfahren 医学-核医学

CiteScore

1.20

自引率

5.60%

发文量

340

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