The Paradigm Shift of Using Natural Molecules Extracted from Northern Canada to Combat Malaria.

IF 3.4 Q2 INFECTIOUS DISEASES Infectious Disease Reports Pub Date : 2024-06-26 DOI:10.3390/idr16040041
Alexandra Bourgeois, Juliana Aline Souza Lemos, Stéphanie Roucheray, Audrey Sergerie, Dave Richard
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Abstract

Parasitic diseases, such as malaria, are an immense burden to many low- and middle-income countries. In 2022, 249 million cases and 608,000 deaths were reported by the World Health Organization for malaria alone. Climate change, conflict, humanitarian crises, resource constraints and diverse biological challenges threaten progress in the elimination of malaria. Undeniably, the lack of a commercialized vaccine and the spread of drug-resistant parasites beg the need for novel approaches to treat this infectious disease. Most approaches for the development of antimalarials to date take inspiration from tropical or sub-tropical environments; however, it is necessary to expand our search. In this review, we highlight the origin of antimalarial treatments and propose new insights in the search for developing novel antiparasitic treatments. Plants and microorganisms living in harsh and cold environments, such as those found in the largely unexploited Northern Canadian boreal forest, often demonstrate interesting properties that are not found in other environments. Most prominently, the essential oil of Rhododendron tomentosum spp. Subarcticum from Nunavik and mortiamides isolated from Mortierella species found in Nunavut have shown promising activity against Plasmodium falciparum.

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利用从加拿大北部提取的天然分子抗击疟疾的范式转变。
疟疾等寄生虫病是许多中低收入国家的沉重负担。2022 年,世界卫生组织报告的疟疾病例就达 2.49 亿例,死亡 60.8 万人。气候变化、冲突、人道主义危机、资源限制和各种生物挑战威胁着消除疟疾工作的进展。不可否认的是,由于缺乏商业化疫苗和抗药性寄生虫的蔓延,治疗这种传染病需要新的方法。迄今为止,开发抗疟药物的大多数方法都是从热带或亚热带环境中汲取灵感;然而,我们有必要扩大搜索范围。在这篇综述中,我们将重点介绍抗疟药物的起源,并就开发新型抗寄生虫药物提出新的见解。生活在严酷和寒冷环境中的植物和微生物,例如那些在加拿大北部北方森林中发现的植物和微生物,往往表现出在其他环境中找不到的有趣特性。最突出的是,来自努纳维克的杜鹃花属植物 Subarcticum 的精油和从努纳武特的 Mortierella 物种中分离出的吗替麦酰胺对恶性疟原虫具有良好的活性。
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来源期刊
Infectious Disease Reports
Infectious Disease Reports INFECTIOUS DISEASES-
CiteScore
5.10
自引率
0.00%
发文量
82
审稿时长
11 weeks
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