Reproductive characteristics and success rate of intracytoplasmic sperm microinjection in spinal cord injury infertile men: Retrospective cohort study.

IF 1.4 4区医学 Q4 ENGINEERING, BIOMEDICAL Technology and Health Care Pub Date : 2024-07-14 DOI:10.3233/THC-240518

Ermin Čehić, Anis Cerovac, Tarik Zulović, Edin Begić

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Abstract

Background: Thanks to modern methods of assisted reproduction (ART), parenthood has become an attainable goal for couples in which the male partner has experienced spinal cord injury (SCI).

Objective: The aim of our study was to determine the success of the treatment of infertile patients with SCI with intracytoplasmic sperm injection (ICSI) of cryopreserved sperm obtained by the testicular sperm aspiration (TESA) procedure.

Methods: In this retrospective study 156 infertile couples were included, in which the male partner is primarily infertile due to azoospermia. Infertile couples were divided into two groups. The first group (n= 82) includes men with SCI, and the second (n= 74) men with obstructive azoospermia (OA) as the cause of infertility. All infertile men were examined and processed in the diagnostic procedure, and based on the urological findings, surgical extraction of sperm from the testicles was indicated. Exclusion criteria were the age of women over 40 and men over 45.

Results: We found that the quality of sperm was worse in the group with SCI, compared to the group with OA, but without statistical significance. Zenica and Johnsen score (p= 0.001; p= 0.000) showed worse semen characteristics in the group with SCI. There were no significant differences in the average number of embryos (p= 0.698), pregnancy rates per cycle (p= 0.979) and pregnancy rates per embrio transfer (ET), clinical pregnancy rates per ET (p= 0.987) and delivery rates per ET (p= 0.804) in couples with SCI, compared to couples with OA.

Conclusion: Based on the results of this research, the TESA and ICSI procedures can be recommended as a successful method in the treatment of male infertility caused by azoospermia due to SCI.

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脊髓损伤不育男性卵胞浆内单精子显微注射的生殖特征和成功率：回顾性队列研究。

背景：由于采用了现代辅助生殖（ART）方法，男性脊髓损伤（SCI）夫妇可以实现为人父母的目标：由于采用了现代辅助生殖（ART）方法，对于男方患有脊髓损伤（SCI）的夫妇来说，生儿育女已成为一个可以实现的目标：我们的研究旨在确定通过睾丸精子抽吸术（TESA）获得的冷冻保存精子进行卵胞浆内单精子显微注射（ICSI）治疗脊髓损伤不育患者的成功率：在这项回顾性研究中，共纳入了 156 对不育夫妇，其中男方主要因无精子症而不育。不育夫妇被分为两组。第一组（n= 82）包括患有 SCI 的男性，第二组（n= 74）包括以梗阻性无精子症（OA）为不育原因的男性。所有不育男性都在诊断程序中接受了检查和处理，并根据泌尿科检查结果，决定通过手术从睾丸中提取精子。排除标准是女性年龄超过 40 岁，男性年龄超过 45 岁：我们发现，与 OA 组相比，SCI 组的精子质量较差，但无统计学意义。Zenica和Johnsen评分（P= 0.001；P= 0.000）显示，患有SCI的一组精液特征较差。与OA夫妇相比，SCI夫妇的平均胚胎数（p= 0.698）、每个周期的妊娠率（p= 0.979）、每次胚胎移植（ET）的妊娠率、每次ET的临床妊娠率（p= 0.987）和每次ET的分娩率（p= 0.804）均无明显差异：根据这项研究的结果，TESA和ICSI程序可被推荐为治疗因SCI导致的无精子症引起的男性不育症的成功方法。

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来源期刊

Technology and Health Care HEALTH CARE SCIENCES & SERVICES-ENGINEERING, BIOMEDICAL

CiteScore

2.10

自引率

6.20%

发文量

282

审稿时长

>12 weeks

期刊介绍： Technology and Health Care is intended to serve as a forum for the presentation of original articles and technical notes, observing rigorous scientific standards. Furthermore, upon invitation, reviews, tutorials, discussion papers and minisymposia are featured. The main focus of THC is related to the overlapping areas of engineering and medicine. The following types of contributions are considered: 1.Original articles: New concepts, procedures and devices associated with the use of technology in medical research and clinical practice are presented to a readership with a widespread background in engineering and/or medicine. In particular, the clinical benefit deriving from the application of engineering methods and devices in clinical medicine should be demonstrated. Typically, full length original contributions have a length of 4000 words, thereby taking duly into account figures and tables. 2.Technical Notes and Short Communications: Technical Notes relate to novel technical developments with relevance for clinical medicine. In Short Communications, clinical applications are shortly described. 3.Both Technical Notes and Short Communications typically have a length of 1500 words. Reviews and Tutorials (upon invitation only): Tutorial and educational articles for persons with a primarily medical background on principles of engineering with particular significance for biomedical applications and vice versa are presented. The Editorial Board is responsible for the selection of topics. 4.Minisymposia (upon invitation only): Under the leadership of a Special Editor, controversial or important issues relating to health care are highlighted and discussed by various authors. 5.Letters to the Editors: Discussions or short statements (not indexed).