Affinity-based drug delivery systems for the central nervous system: exploiting molecular interactions for local, precise targeting.

Pablo Ramos Ferrer, Shelly Sakiyama-Elbert
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Abstract

Objective: The effective treatment of central nervous system (CNS) disorders remains a significant challenge, primarily due to its molecular and structural complexity. Clinical translation of promising therapeutic agents is limited by the lack of optimal drug delivery systems capable of targeted, localized release of drugs to the brain and spinal cord.Approach: This review provides an overview of the potential of affinity-based drug delivery systems, which leverage molecular interactions to enhance the delivery and efficacy of therapeutic agents within the CNS.Main results: Various approaches, including hydrogels, micro- and nanoparticles, and functionalized biomaterials, are examined for their ability to provide local, sustained release of proteins, growth factors and other drugs.Significance: Furthermore, we present a detailed analysis of design considerations for developing effective affinity-based systems, incorporating insights from both existing literature and our group's research. These considerations include the biochemical modification of delivery vehicles and the optimization of physical and chemical properties to improve therapeutic outcomes.

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用于中枢神经系统的基于亲和力的给药系统:利用分子相互作用实现局部精确靶向。
中枢神经系统(CNS)疾病的有效治疗仍然是一项重大挑战,这主要是由于其分子和结构的复杂性。由于缺乏能够向大脑和脊髓定向、局部释放药物的最佳给药系统,有前景的治疗药物的临床转化受到了限制。本综述概述了基于亲和力的给药系统的潜力,这些系统利用分子间的相互作用来提高治疗药物在中枢神经系统内的给药和疗效。我们研究了包括水凝胶、微型和纳米颗粒以及功能化生物材料在内的各种方法,以了解它们在局部持续释放蛋白质、生长因子和其他药物方面的能力。此外,我们还结合现有文献和本研究小组的研究成果,详细分析了开发有效亲和系统的设计注意事项。这些考虑因素包括对递送载体进行生化修饰以及优化物理和化学特性,以改善治疗效果。
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