The Mediating Effect of Symptom Burden in the Depression and Quality of Life in Patients with Maintenance Hemodialysis.

IF 2.8 3区心理学 Q2 PSYCHOLOGY, CLINICAL Psychology Research and Behavior Management Pub Date : 2024-07-22 eCollection Date: 2024-01-01 DOI:10.2147/PRBM.S465215

Ning-Ning Xia, Kuei-Ching Pan, Jing Liu, Daxi Ji

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Abstract

Objective: To investigate current status of quality of life and the association between depression and symptom burden in a sample of Chinese maintenance hemodialysis (MHD) patients.

Methods: A self-designed patient general information questionnaire, disease-related information questionnaire, dialysis patient symptom burden scale, depression scale, and quality of survival scale were used to investigate 380 maintenance haemodialysis patients in haemodialysis centres. A regression model of the factors affecting the quality of survival was established using structural equation modelling.

Results: The regression model data had a high goodness of fit: c²/df = 4.736, RMSEA = 0.099, GFI = 0.918, CFI = 0.972, TLI = 0.962, SRMR = 0.0469. Structural equation model analysis showed that depression had a positive predictive effect on symptom burden, β = 0.398, P < 0.001; Symptom burden had a negative predictive effect on the quality of life, β =-0.851, P < 0.001; and Depression had a negative predictive effect on the quality of life, β =-0.151, P < 0.001. Depression indirectly affects the quality of life through symptom burdens.

Conclusion: Depression and symptom burden directly or indirectly affect the quality of life in patients with maintenance hemodialysis. Symptom burden moderates the relationship between depression and quality of life as a mediating variable.

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症状负担对维持性血液透析患者抑郁和生活质量的中介效应。

目的调查中国维持性血液透析（MHD）患者的生活质量现状以及抑郁与症状负担之间的关系：方法：采用自行设计的患者一般信息问卷、疾病相关信息问卷、透析患者症状负担量表、抑郁量表和生存质量量表，对血液透析中心的 380 名维持性血液透析患者进行调查。采用结构方程模型建立了影响生存质量因素的回归模型：回归模型数据拟合度较高：c2/df = 4.736，RMSEA = 0.099，GFI = 0.918，CFI = 0.972，TLI = 0.962，SRR = 0.0469。结构方程模型分析显示，抑郁对症状负担有正向预测作用，β = 0.398，P 0.001；症状负担对生活质量有负向预测作用，β =-0.851，P 0.001；抑郁对生活质量有负向预测作用，β =-0.151，P < 0.001。抑郁症通过症状负担间接影响生活质量：抑郁和症状负担直接或间接影响维持性血液透析患者的生活质量。症状负担作为中介变量调节抑郁与生活质量之间的关系。

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来源期刊

Psychology Research and Behavior Management Multiple-

CiteScore

4.50

自引率

4.70%

发文量

341

审稿时长

16 weeks

期刊介绍： Psychology Research and Behavior Management is an international, peer-reviewed, open access journal focusing on the science of psychology and its application in behavior management to develop improved outcomes in the clinical, educational, sports and business arenas. Specific topics covered in the journal include: -Neuroscience, memory and decision making -Behavior modification and management -Clinical applications -Business and sports performance management -Social and developmental studies -Animal studies The journal welcomes submitted papers covering original research, clinical studies, surveys, reviews and evaluations, guidelines, expert opinion and commentary, case reports and extended reports.