Contemporary Nanoemulsion Research: Extensive Examination of Self-Nanoemulsifying Drug Delivery Systems

Abstract

The administration of new pharmaceutical compounds orally can pose certain challenges in terms of drug absorption, bioavailability, and pharmacokinetic profile. However, a widely recognized method for enhancing bioavailability involves lipid-based drug delivery systems. Lipid-based drug delivery systems (LBDDS) are the most favourable method for formulating medicines that have low solubility in water. Nanotechnology exerts a significant impact on the therapeutic efficacy of hydrophobic medicines and has emerged as a crucial method in the field of drug delivery research. Self-nanoemulsifying drug delivery systems (SNEDDs) are an important approach that combines the advantages of lipid-based drug delivery systems (LBDDS) and nanotechnology. SNEDDs are currently the favoured method for enhancing the formulation of pharmaceuticals that have low solubility in water. SNEDDs are homogenous mixtures that can self-emulsify spontaneously with gentle stirring, forming an oil-in-water emulsion that conveniently protects and creates a pathway for the lipophilic drug. The small particle size of <200nm increases the solubilisation capacity of the drug by increasing its surface area. SNEDDs have demonstrated the ability to enhance the bioavailability of medicines that are not easily soluble in water. SNEDDs stand apart from other solubility enhancement approaches due to their inclusion of biodegradable components, their ease of large-scale manufacture, and their numerous potential for drug targeting. The aim of the present review was to provide basic knowledge about formulation, applications, and benefits of using SNEDDs. A detailed manuscript has been prepared by doing a literature survey on databases like Google Scholar, SCOPUS, and Pubmed to review the current state of nanotechnology applications, industrial developments, and challenges for using SNEDDS as a novel delivery system is provided in this manuscript.