Pub Date : 2024-07-18DOI: 10.2174/0124681873304985240627061125
Aakriti Patel, Astha Singh, Neha Minocha
The administration of new pharmaceutical compounds orally can pose certain challenges in terms of drug absorption, bioavailability, and pharmacokinetic profile. However, a widely recognized method for enhancing bioavailability involves lipid-based drug delivery systems. Lipid-based drug delivery systems (LBDDS) are the most favourable method for formulating medicines that have low solubility in water. Nanotechnology exerts a significant impact on the therapeutic efficacy of hydrophobic medicines and has emerged as a crucial method in the field of drug delivery research. Self-nanoemulsifying drug delivery systems (SNEDDs) are an important approach that combines the advantages of lipid-based drug delivery systems (LBDDS) and nanotechnology. SNEDDs are currently the favoured method for enhancing the formulation of pharmaceuticals that have low solubility in water. SNEDDs are homogenous mixtures that can self-emulsify spontaneously with gentle stirring, forming an oil-in-water emulsion that conveniently protects and creates a pathway for the lipophilic drug. The small particle size of <200nm increases the solubilisation capacity of the drug by increasing its surface area. SNEDDs have demonstrated the ability to enhance the bioavailability of medicines that are not easily soluble in water. SNEDDs stand apart from other solubility enhancement approaches due to their inclusion of biodegradable components, their ease of large-scale manufacture, and their numerous potential for drug targeting. The aim of the present review was to provide basic knowledge about formulation, applications, and benefits of using SNEDDs. A detailed manuscript has been prepared by doing a literature survey on databases like Google Scholar, SCOPUS, and Pubmed to review the current state of nanotechnology applications, industrial developments, and challenges for using SNEDDS as a novel delivery system is provided in this manuscript.
{"title":"Contemporary Nanoemulsion Research: Extensive Examination of Self-Nanoemulsifying Drug Delivery Systems","authors":"Aakriti Patel, Astha Singh, Neha Minocha","doi":"10.2174/0124681873304985240627061125","DOIUrl":"https://doi.org/10.2174/0124681873304985240627061125","url":null,"abstract":"\u0000\u0000The administration of new pharmaceutical compounds orally can pose certain challenges\u0000in terms of drug absorption, bioavailability, and pharmacokinetic profile. However, a widely\u0000recognized method for enhancing bioavailability involves lipid-based drug delivery systems.\u0000Lipid-based drug delivery systems (LBDDS) are the most favourable method for formulating\u0000medicines that have low solubility in water. Nanotechnology exerts a significant impact on the\u0000therapeutic efficacy of hydrophobic medicines and has emerged as a crucial method in the field of\u0000drug delivery research. Self-nanoemulsifying drug delivery systems (SNEDDs) are an important\u0000approach that combines the advantages of lipid-based drug delivery systems (LBDDS) and nanotechnology.\u0000SNEDDs are currently the favoured method for enhancing the formulation of pharmaceuticals\u0000that have low solubility in water. SNEDDs are homogenous mixtures that can self-emulsify\u0000spontaneously with gentle stirring, forming an oil-in-water emulsion that conveniently protects\u0000and creates a pathway for the lipophilic drug. The small particle size of <200nm increases\u0000the solubilisation capacity of the drug by increasing its surface area. SNEDDs have demonstrated\u0000the ability to enhance the bioavailability of medicines that are not easily soluble in water.\u0000SNEDDs stand apart from other solubility enhancement approaches due to their inclusion of\u0000biodegradable components, their ease of large-scale manufacture, and their numerous potential for\u0000drug targeting. The aim of the present review was to provide basic knowledge about formulation,\u0000applications, and benefits of using SNEDDs. A detailed manuscript has been prepared by doing a\u0000literature survey on databases like Google Scholar, SCOPUS, and Pubmed to review the current\u0000state of nanotechnology applications, industrial developments, and challenges for using SNEDDS\u0000as a novel delivery system is provided in this manuscript.\u0000","PeriodicalId":10818,"journal":{"name":"Current Nanomedicine","volume":" 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141824680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-05DOI: 10.2174/0124681873312057240622175745
Archna Singh, Avijit Mazumder, Saumya Das, Rashmi Mishra, M. Chaitanya
Alzheimer's disease (AD), a progressive neurodegenerative disorder, arises from the buildup of beta-amyloid plaques within the intricate neural networks of the brain. A lasting remedy for Alzheimer's disease remains elusive, as current pharmaceutical options merely offer the potential to decelerate its advancement. Nevertheless, nanotechnology has demonstrated its efficacy in the realm of medical interventions. Nanotechnology holds immense promise for the treatment of Alzheimer's disease, particularly in the realms of disease detection and providing alternative therapeutic approaches. With its demonstrated superiority in medical applications, nanotechnology emerges as a potent tool with significant potential in addressing the complexities of Alzheimer's disease, offering enhanced diagnostics and novel treatment strategies. This feat is achieved by augmenting the efficacy of drug administration through the penetration and surmounting of the BBB. Nonetheless, it is crucial to thoroughly investigate and explore the limitations at hand, aiming to minimize undesired side effects and potential toxicity while enhancing medication absorption, thereby optimizing the overall therapeutic outcome. Cutting-edge breakthroughs in Alzheimer's disease treatment utilizing nanotechnology encompass a spectrum of remarkable advancements, including stem cell regeneration, nanomedicine, and neuroprotection. The present investigation delves into the remarkable strides made in nanotechnology, specifically examining its pivotal role in detecting and treating neurodegenerative disorders such as Alzheimer's while shedding light on the challenges ahead.
{"title":"Nanomedicine in Alzheimer’s Therapy: Enhancing Drug Delivery\u0000Strategies","authors":"Archna Singh, Avijit Mazumder, Saumya Das, Rashmi Mishra, M. Chaitanya","doi":"10.2174/0124681873312057240622175745","DOIUrl":"https://doi.org/10.2174/0124681873312057240622175745","url":null,"abstract":"\u0000\u0000Alzheimer's disease (AD), a progressive neurodegenerative disorder, arises from the\u0000buildup of beta-amyloid plaques within the intricate neural networks of the brain. A lasting remedy\u0000for Alzheimer's disease remains elusive, as current pharmaceutical options merely offer the potential\u0000to decelerate its advancement. Nevertheless, nanotechnology has demonstrated its efficacy\u0000in the realm of medical interventions. Nanotechnology holds immense promise for the treatment\u0000of Alzheimer's disease, particularly in the realms of disease detection and providing alternative\u0000therapeutic approaches. With its demonstrated superiority in medical applications, nanotechnology\u0000emerges as a potent tool with significant potential in addressing the complexities of\u0000Alzheimer's disease, offering enhanced diagnostics and novel treatment strategies. This feat is\u0000achieved by augmenting the efficacy of drug administration through the penetration and surmounting\u0000of the BBB.\u0000Nonetheless, it is crucial to thoroughly investigate and explore the limitations at hand, aiming to\u0000minimize undesired side effects and potential toxicity while enhancing medication absorption,\u0000thereby optimizing the overall therapeutic outcome. Cutting-edge breakthroughs in Alzheimer's\u0000disease treatment utilizing nanotechnology encompass a spectrum of remarkable advancements, including\u0000stem cell regeneration, nanomedicine, and neuroprotection. The present investigation\u0000delves into the remarkable strides made in nanotechnology, specifically examining its pivotal role\u0000in detecting and treating neurodegenerative disorders such as Alzheimer's while shedding light on\u0000the challenges ahead.\u0000","PeriodicalId":10818,"journal":{"name":"Current Nanomedicine","volume":" 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141674547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.2174/0124681873270131231023082115
A. Rani, R. Verma, Manish Kumar, Abhishek Tiwari, V. Tiwari, Shailendra Bhatt, Vineet Mittal, Deepak Kaushik
Solubility is a critical factor for the therapeutic action of drugs and does not depend on the administration of routes. Various conventional methods are used to enhance the solubility of the drug, which show limited applicability. Nanotechnology is used to improve the solubility and bioavailability of drugs that belong to BCS classes II and IV. Nanosuspension is the dispersion of pure drug nanoparticles in aqueous with a minimum amount of surfactant, stabilizing the formula-tion. Various techniques, such as the bottom-up approach, dissocubes, nanopure, nanoedge, nano-jet process, supercritical fluid, dry co-grinding, milling media, and nanoprecipitation, have been used to formulate nanosuspension. Nanosuspension can be administered orally, inhalation, trans-dermal, ocular, injectable, topical, and pulmonary. To resolve the problem of solubility and stabil-ity, nanosuspension has received much attention because of its technical simplicity, cost-effectiveness, and ease of significant scale-up. Nanosuspension can control particle size surface charge properties and release the drug at specific sites at an optimal rate. Recently, more than 100 patents have been published on nanosuspension. This review article covers the different prepara-tion methods, formulation composition, marketed products, characterization, and recent patents on nanosuspension. The various benefits and evaluation of the parameters of nanosuspension are discussed briefly. This patent-based review will enhance the knowledge of control drug delivery and related patents on nanosuspension.
{"title":"Nanosuspension as a Novel Nanovehicle for Drug Delivery: A Recent\u0000Update on Patents and Therapeutic Applications","authors":"A. Rani, R. Verma, Manish Kumar, Abhishek Tiwari, V. Tiwari, Shailendra Bhatt, Vineet Mittal, Deepak Kaushik","doi":"10.2174/0124681873270131231023082115","DOIUrl":"https://doi.org/10.2174/0124681873270131231023082115","url":null,"abstract":"\u0000\u0000Solubility is a critical factor for the therapeutic action of drugs and does not depend on the administration of routes. Various conventional methods are used to enhance the solubility of the drug, which show limited applicability. Nanotechnology is used to improve the solubility and bioavailability of drugs that belong to BCS classes II and IV. Nanosuspension is the dispersion of pure drug nanoparticles in aqueous with a minimum amount of surfactant, stabilizing the formula-tion. Various techniques, such as the bottom-up approach, dissocubes, nanopure, nanoedge, nano-jet process, supercritical fluid, dry co-grinding, milling media, and nanoprecipitation, have been used to formulate nanosuspension. Nanosuspension can be administered orally, inhalation, trans-dermal, ocular, injectable, topical, and pulmonary. To resolve the problem of solubility and stabil-ity, nanosuspension has received much attention because of its technical simplicity, cost-effectiveness, and ease of significant scale-up. Nanosuspension can control particle size surface charge properties and release the drug at specific sites at an optimal rate. Recently, more than 100 patents have been published on nanosuspension. This review article covers the different prepara-tion methods, formulation composition, marketed products, characterization, and recent patents on nanosuspension. The various benefits and evaluation of the parameters of nanosuspension are discussed briefly. This patent-based review will enhance the knowledge of control drug delivery and related patents on nanosuspension.\u0000","PeriodicalId":10818,"journal":{"name":"Current Nanomedicine","volume":"26 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141701947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
There is an urgent need of advanced techniques/technologies for the treatment of can-cer as it is becoming the major cause of mortality and morbidity worldwide. The improvement of the cancer drug delivery system has been made possible by the formation of novel nanomaterials and nanocarriers. The nanocarriers prevent rapid degradation of the drug and thereby deliver the drug to a specific tumor site at therapeutic concentrations, meanwhile reducing the adverse/side effects by avoiding the delivery of the drug to normal sites. The antitumor activity can be en-hanced by increasing the tumoral uptake of nanocarriers. By delivering the nanocarriers either by active or passive targeting, the tumoral uptake can be increased. The pharmacokinetics, pharma-codynamics, and safety profile of the drug are determined by structural and physical factors like size, charge, shape, and other surface characteristics, hence the design of the nanoparticles is an important factor. In the present review, the mechanism of cellular targeting, along with the differ-ent nanoparticles used in cancer therapy is discussed. Nanotechnology have gained huge ground due to improved diagnosis and treatment additionally saving the time and resources, which makes this technology to get more landscape for researchers/ oncologists.
{"title":"Nanotechnological Carriers in the Treatment of Cancer: A Review","authors":"Darsh Gautam, Poonam Talwan, Sanjay Kumar, Gaurav Joshi, Ranjit Singh","doi":"10.2174/0124681873270774231008100554","DOIUrl":"https://doi.org/10.2174/0124681873270774231008100554","url":null,"abstract":"\u0000\u0000There is an urgent need of advanced techniques/technologies for the treatment of can-cer as it is becoming the major cause of mortality and morbidity worldwide. The improvement of the cancer drug delivery system has been made possible by the formation of novel nanomaterials and nanocarriers. The nanocarriers prevent rapid degradation of the drug and thereby deliver the drug to a specific tumor site at therapeutic concentrations, meanwhile reducing the adverse/side effects by avoiding the delivery of the drug to normal sites. The antitumor activity can be en-hanced by increasing the tumoral uptake of nanocarriers. By delivering the nanocarriers either by active or passive targeting, the tumoral uptake can be increased. The pharmacokinetics, pharma-codynamics, and safety profile of the drug are determined by structural and physical factors like size, charge, shape, and other surface characteristics, hence the design of the nanoparticles is an important factor. In the present review, the mechanism of cellular targeting, along with the differ-ent nanoparticles used in cancer therapy is discussed. Nanotechnology have gained huge ground due to improved diagnosis and treatment additionally saving the time and resources, which makes this technology to get more landscape for researchers/ oncologists.\u0000","PeriodicalId":10818,"journal":{"name":"Current Nanomedicine","volume":"57 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141710248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-13DOI: 10.2174/0124681873299099240530075454
Shivani Yadav, Manoj Kumar Mishra
Nanocrystals, composed of a few hundred to tens of thousands of atoms, coalesce to form crystalline clusters, revolutionizing the landscape of pharmaceutical compounds. These clusters, often referred to as “clusters,” serve as crystalline structures that wield significant influence over the pharmacokinetic and pharmacodynamic characteristics of diverse pharmacological agents. Employed for various applications, nanocrystals play a pivotal role in safeguarding drug entities during systemic circulation within the body. The production of nanocrystals employs diverse methodologies, including spray drying, top-down approaches, bottom-up strategies, and innovative techniques. The formulation of nanocrystals yields a spectrum of advantages, such as augmenting oral bioavailability, optimizing dose proportionality, mitigating food-related effects, ensuring suitability for administration through diverse routes, and enabling sterile filtration due to a more confined particle size range. The selection of the appropriate method is contingent upon the specific target sites and the drug's capacity to reach the intended site of action consistently and at a controlled rate. This exploration delves into several facets of nanocrystals in drug delivery, shedding light on their multifaceted uses within the pharmaceutical realm.
{"title":"Nanocrystals in Drug Delivery: A Cutting-Edge Approach for Enhanced Therapeutic Values","authors":"Shivani Yadav, Manoj Kumar Mishra","doi":"10.2174/0124681873299099240530075454","DOIUrl":"https://doi.org/10.2174/0124681873299099240530075454","url":null,"abstract":"\u0000\u0000Nanocrystals, composed of a few hundred to tens of thousands of atoms, coalesce to\u0000form crystalline clusters, revolutionizing the landscape of pharmaceutical compounds. These clusters,\u0000often referred to as “clusters,” serve as crystalline structures that wield significant influence\u0000over the pharmacokinetic and pharmacodynamic characteristics of diverse pharmacological\u0000agents. Employed for various applications, nanocrystals play a pivotal role in safeguarding drug\u0000entities during systemic circulation within the body. The production of nanocrystals employs diverse\u0000methodologies, including spray drying, top-down approaches, bottom-up strategies, and innovative\u0000techniques. The formulation of nanocrystals yields a spectrum of advantages, such as augmenting\u0000oral bioavailability, optimizing dose proportionality, mitigating food-related effects, ensuring\u0000suitability for administration through diverse routes, and enabling sterile filtration due to a\u0000more confined particle size range. The selection of the appropriate method is contingent upon the\u0000specific target sites and the drug's capacity to reach the intended site of action consistently and at\u0000a controlled rate. This exploration delves into several facets of nanocrystals in drug delivery, shedding\u0000light on their multifaceted uses within the pharmaceutical realm.\u0000","PeriodicalId":10818,"journal":{"name":"Current Nanomedicine","volume":"49 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141345776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-12DOI: 10.2174/0124681873318371240604062807
S. Bahadur, Gaurav Agrawal
Green chemistry has been recognised as a new prominent field that endeavours to work at the molecular level to achieve sustainability in the various area of pharmaceuticals. Sustainable chemistry can be defined as the formation of chemical products which reduces the generation of toxic and harmful substances. Hence, green chemistry may decrease pollution and risks of chemical release into the biosphere. Green chemistry has various applications in specific fields like pharmaceutical product development, analytical chemistry and chemical synthesis methods. The applications of green chemistry and nanotechnology for drug delivery in pharmaceuticals can enhance safety and effectiveness. The pollution resulting from conventional methods creates a requirement for environmentally friendly methods. Green nanotechnology may be useful in several areas of biomedical, such as plant extract may be used for the development of advanced novel nanoparticles with the need for progress in biomedicine, antibacterial, nano-biotechnology, sensing and in electrochemical, cosmetics, electronics, biosensors and other applications. The green chemistry approaches may be implemented in various sectors of the pharmaceutical industry, such as biocatalysts, green solvents, green nanotechnology, etc. Hence, the present review article highlights several aspects of green chemistry and its applications in waste management and pollution control. Further, the pharmaceutical application of green chemistry has been discussed.
{"title":"A Review on Current Prospective and Applications of Green Nanoparticles in Biomedical Applications","authors":"S. Bahadur, Gaurav Agrawal","doi":"10.2174/0124681873318371240604062807","DOIUrl":"https://doi.org/10.2174/0124681873318371240604062807","url":null,"abstract":"\u0000\u0000Green chemistry has been recognised as a new prominent field that endeavours to work\u0000at the molecular level to achieve sustainability in the various area of pharmaceuticals. Sustainable\u0000chemistry can be defined as the formation of chemical products which reduces the generation of\u0000toxic and harmful substances. Hence, green chemistry may decrease pollution and risks of chemical\u0000release into the biosphere. Green chemistry has various applications in specific fields like pharmaceutical\u0000product development, analytical chemistry and chemical synthesis methods. The applications\u0000of green chemistry and nanotechnology for drug delivery in pharmaceuticals can enhance\u0000safety and effectiveness. The pollution resulting from conventional methods creates a requirement\u0000for environmentally friendly methods. Green nanotechnology may be useful in several areas of\u0000biomedical, such as plant extract may be used for the development of advanced novel nanoparticles\u0000with the need for progress in biomedicine, antibacterial, nano-biotechnology, sensing and in\u0000electrochemical, cosmetics, electronics, biosensors and other applications. The green chemistry approaches\u0000may be implemented in various sectors of the pharmaceutical industry, such as biocatalysts,\u0000green solvents, green nanotechnology, etc. Hence, the present review article highlights several\u0000aspects of green chemistry and its applications in waste management and pollution control.\u0000Further, the pharmaceutical application of green chemistry has been discussed.\u0000","PeriodicalId":10818,"journal":{"name":"Current Nanomedicine","volume":"13 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141355220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-07DOI: 10.2174/0124681873309210240525182209
Sourav De, Sabyasachi Banerjee, Nibir Ghosh, Gourab Dey, Subhasis Banerjee, Ashok Kumar S K
Cancer is the second leading cause of global mortality. Modern medical technologies, including chemotherapy, radiation treatment, and surgery, are extending the lifespan of cancer patients. The potential of nano medicine opens up a new way to get over the restrictions of traditional cancer treatments. Due to their unique basic features, gold nanoparticles (AuNPs) have been extensively explored and used in the field of tumor diagnostics and therapy. Two perspectives are presented on the physical and chemical aspects of AuNPs' characteristics. Localized surface plasmon resonance (LSPR), radioactivity, and a high X-ray absorption coefficient are among the physical characteristics of AuNPs that are commonly employed in tumor diagnostics and therapy. AuNPs also have some advantages like customizable size and shape, as well as various physiochemical properties. Additionally, they can effectively encapsulate drugs to enable simultaneous therapy and incorporate supplementary imaging labels. Recent research has emphasized the use of multifunctional AuNPs in techniques that involve simultaneous diagnosis and therapy. This article explores the use of AuNPs in cancer diagnosis and treatment, detailing clinical trials and providing insights for researchers on their physiochemical properties.
{"title":"Role of Gold Nanoparticles for Diagnosis and Therapy of Malignancy","authors":"Sourav De, Sabyasachi Banerjee, Nibir Ghosh, Gourab Dey, Subhasis Banerjee, Ashok Kumar S K","doi":"10.2174/0124681873309210240525182209","DOIUrl":"https://doi.org/10.2174/0124681873309210240525182209","url":null,"abstract":"\u0000\u0000Cancer is the second leading cause of global mortality. Modern medical technologies,\u0000including chemotherapy, radiation treatment, and surgery, are extending the lifespan of cancer patients.\u0000The potential of nano medicine opens up a new way to get over the restrictions of traditional\u0000cancer treatments. Due to their unique basic features, gold nanoparticles (AuNPs) have been extensively\u0000explored and used in the field of tumor diagnostics and therapy. Two perspectives are\u0000presented on the physical and chemical aspects of AuNPs' characteristics. Localized surface plasmon\u0000resonance (LSPR), radioactivity, and a high X-ray absorption coefficient are among the physical\u0000characteristics of AuNPs that are commonly employed in tumor diagnostics and therapy.\u0000AuNPs also have some advantages like customizable size and shape, as well as various physiochemical\u0000properties. Additionally, they can effectively encapsulate drugs to enable simultaneous\u0000therapy and incorporate supplementary imaging labels. Recent research has emphasized the use of\u0000multifunctional AuNPs in techniques that involve simultaneous diagnosis and therapy. This article\u0000explores the use of AuNPs in cancer diagnosis and treatment, detailing clinical trials and providing\u0000insights for researchers on their physiochemical properties.\u0000","PeriodicalId":10818,"journal":{"name":"Current Nanomedicine","volume":" 44","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141372877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-20DOI: 10.2174/0124681873293988240508094705
Sahar Masoudi, A. Torab, R. Negahdari, Solmaz Maleki Dizaj, Simin Sharifi, S. Salatin
Considering the success of dental implant treatments and their long-term effectiveness, it is important to prevent a series of biological complications such as peri-implant diseases. The development of antimicrobial coatings is known as a promising strategy to overcome these challenges. This study aimed to investigate the durability of simvastatin-loaded gelatin nanoparticle coating on titanium healing abutments. 40 titanium healing abutments were prepared in two groups, including the test group (titanium healing abutments coated with simvastatin nanoparticles, n=20) and the control group (titanium healing abutments without simvastatin nanoparticle coating, n=20). The dip-coating process was then applied to cover the surface of the healing-abutments. The morphology and composition of coatings were evaluated by Scanning Electron Microscope (SEM) and X-Ray Diffraction analysis (XRD), respectively. The resulting data from SEM and XRD confirmed the successful coating of simvastatin- loaded gelatin nanoparticles on the implant. Based on the Sidak test results, it was observed that the average weight before coating and immediately after coating had a significant difference. Also, the average weight between the initial time (after coating) and the time of 1 day after coating and 30 days after coating was not statistically significant. It means that the coating has been stable for at least 30 days. The difference between the initial weight (after coating) and 60 days after plating was significant. This means that the durability of the coating has decreased until the 60th day. The resulting data showed that the coating of gelatinous nanoparticles containing simvastatin on the titanium healing abutments was successful, and the durability of the coating lasted for at least 1 month.
{"title":"The Durability of Simvastatin Nanoparticle Coatings on Dental Implant Healing-Abutments","authors":"Sahar Masoudi, A. Torab, R. Negahdari, Solmaz Maleki Dizaj, Simin Sharifi, S. Salatin","doi":"10.2174/0124681873293988240508094705","DOIUrl":"https://doi.org/10.2174/0124681873293988240508094705","url":null,"abstract":"\u0000\u0000Considering the success of dental implant treatments and their long-term\u0000effectiveness, it is important to prevent a series of biological complications such as peri-implant\u0000diseases. The development of antimicrobial coatings is known as a promising strategy to overcome\u0000these challenges. This study aimed to investigate the durability of simvastatin-loaded gelatin\u0000nanoparticle coating on titanium healing abutments.\u0000\u0000\u0000\u000040 titanium healing abutments were prepared in two groups, including the test group (titanium\u0000healing abutments coated with simvastatin nanoparticles, n=20) and the control group (titanium\u0000healing abutments without simvastatin nanoparticle coating, n=20). The dip-coating process\u0000was then applied to cover the surface of the healing-abutments. The morphology and composition\u0000of coatings were evaluated by Scanning Electron Microscope (SEM) and X-Ray Diffraction analysis\u0000(XRD), respectively.\u0000\u0000\u0000\u0000The resulting data from SEM and XRD confirmed the successful coating of simvastatin-\u0000loaded gelatin nanoparticles on the implant. Based on the Sidak test results, it was observed\u0000that the average weight before coating and immediately after coating had a significant difference.\u0000Also, the average weight between the initial time (after coating) and the time of 1 day after coating\u0000and 30 days after coating was not statistically significant. It means that the coating has been\u0000stable for at least 30 days. The difference between the initial weight (after coating) and 60 days after\u0000plating was significant. This means that the durability of the coating has decreased until the\u000060th day.\u0000\u0000\u0000\u0000The resulting data showed that the coating of gelatinous nanoparticles containing simvastatin\u0000on the titanium healing abutments was successful, and the durability of the coating lasted\u0000for at least 1 month.\u0000","PeriodicalId":10818,"journal":{"name":"Current Nanomedicine","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141120122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-20DOI: 10.2174/0124681873281058240509114133
Neha Kumari, Sumit Sharma
Ever since the invention of liposomes by Bangham in 1963, researchers have been fascinated by the vesicular carriers. Liposomes and niosomes have been used extensively by researchers for various routes such as oral and nasal. However, lately, it has been understood that traditional liposomes are not very significant when it comes to penetration. The use of nanovesicles in transdermal drug delivery systems has been enhanced exponentially ever since the discovery of ultra- deformable liposomes known as transfersomes or transferosomes. Transferosomes have numerous advantages, such as biocompatibility, biodegradability, flexibility, and deformability, so that they can pass through narrow constrictions. They have good entrapment efficiency and can act as a depot to sustain the release of drugs. The methods of preparation include the rotary film evaporation method, reverse phase evaporation method, vortexing sonication method, ethanol injection method, and freeze-thaw method. Transfersomes are characterized by particle size, zeta potential, polydispersity index, surface morphology, and encapsulation efficiency. Transferosomes have been successfully exploited for the enhancement of efficacy of many drugs like Hydroquinone, Itraconazole, Ivabradine, lornoxicam, minoxidil etc., via transdermal and nasal routes. The technology is easy to scale up. Consequently, it can be inferred that transfersomes are the future of transdermal drug delivery systems.
{"title":"An Overview of Transferosomal Technology","authors":"Neha Kumari, Sumit Sharma","doi":"10.2174/0124681873281058240509114133","DOIUrl":"https://doi.org/10.2174/0124681873281058240509114133","url":null,"abstract":"\u0000\u0000Ever since the invention of liposomes by Bangham in 1963, researchers have been fascinated\u0000by the vesicular carriers. Liposomes and niosomes have been used extensively by researchers\u0000for various routes such as oral and nasal. However, lately, it has been understood that traditional\u0000liposomes are not very significant when it comes to penetration. The use of nanovesicles in\u0000transdermal drug delivery systems has been enhanced exponentially ever since the discovery of ultra-\u0000deformable liposomes known as transfersomes or transferosomes. Transferosomes have numerous\u0000advantages, such as biocompatibility, biodegradability, flexibility, and deformability, so that\u0000they can pass through narrow constrictions. They have good entrapment efficiency and can act as\u0000a depot to sustain the release of drugs. The methods of preparation include the rotary film evaporation\u0000method, reverse phase evaporation method, vortexing sonication method, ethanol injection\u0000method, and freeze-thaw method. Transfersomes are characterized by particle size, zeta potential,\u0000polydispersity index, surface morphology, and encapsulation efficiency. Transferosomes have\u0000been successfully exploited for the enhancement of efficacy of many drugs like Hydroquinone,\u0000Itraconazole, Ivabradine, lornoxicam, minoxidil etc., via transdermal and nasal routes. The technology\u0000is easy to scale up. Consequently, it can be inferred that transfersomes are the future of transdermal\u0000drug delivery systems.\u0000","PeriodicalId":10818,"journal":{"name":"Current Nanomedicine","volume":"48 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141122040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-03DOI: 10.2174/0124681873287041240328133414
S. Beiranvand, F. H. Kiabi
This review focuses on the use of Colchicum species that have been capsuled to treat lower back pain. Low levels of physical activity produce atypical spinal loading, which increases the risk of discomfort and damage. Acetylcholine (AChE inhibitors acetylcholinesterase AChE-I) has a crucial role in the development of amyloid- plaques, one of the disease's main pathogenic processes, and in boosting psychological function. To increase the natural preservatives in food, research on the encapsulation of phytochemicals has been employed to create nanoparticle delivery systems for a combination of terpenes that have been isolated from plants. For the administration of formulations containing encapsulated plant extracts, dermal and oral routes are used. The current strategies of encapsulation should be enhanced, as well as techniques to achieve the goal.
{"title":"Nanoencapsulation of Colchicum speciosum for Alleviating Lower Back Pain","authors":"S. Beiranvand, F. H. Kiabi","doi":"10.2174/0124681873287041240328133414","DOIUrl":"https://doi.org/10.2174/0124681873287041240328133414","url":null,"abstract":"\u0000\u0000This review focuses on the use of Colchicum species that have been capsuled to treat\u0000lower back pain. Low levels of physical activity produce atypical spinal loading, which increases\u0000the risk of discomfort and damage. Acetylcholine (AChE inhibitors acetylcholinesterase AChE-I)\u0000has a crucial role in the development of amyloid- plaques, one of the disease's main pathogenic\u0000processes, and in boosting psychological function. To increase the natural preservatives in food, research\u0000on the encapsulation of phytochemicals has been employed to create nanoparticle delivery\u0000systems for a combination of terpenes that have been isolated from plants. For the administration\u0000of formulations containing encapsulated plant extracts, dermal and oral routes are used. The current\u0000strategies of encapsulation should be enhanced, as well as techniques to achieve the goal.\u0000","PeriodicalId":10818,"journal":{"name":"Current Nanomedicine","volume":"120 S16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141017534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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