COVID-19 Pneumonia-Related ARDS – Can We Predict Mortality with Laboratory Parameters?

Abstract

Objective: To examine the laboratory characteristics of COVID-19 pneumonia-related ARDS patients who lived or died. Materials and methods: Retrospectively, two-center of patients who were hospitalized in the intensive care unit were researched in Abant Izzet Baysal University Education and Research Hospital in Bolu, Turkey. Between March 31 and December 31, 2020, data on the demographic characteristics, routine laboratory results, including arterial blood gas tests, and clinical outcomes were collected for both the survivor and non-survivor groups. Results: The median age of the 509 patients was 70 years (interquartile range, 59-79 years); 326 patients (64%) were men, and 161 patients (31.6%) tested positive for RT-PCR. While 232 (45.6%) patients in the non-survivor group died, 277 patients were discharged (54.4%) as survivors. The mortality markers of WBC, RBC, HGB, Ph, pO2, pCO2, HCO3, PLT, PCT, NEU, ALT, and D-dimer did not differ significantly (p>0.05). CRP, RDW, LDH, ferritin, urea, and creatinine levels were substantially higher and associated with death in the non-survivor group (p 0.05). Conclusion: A greater risk of death was linked to older age and the number of days spent in the hospital, most likely as a result of persistent underlying issues and weakened immune responses. Risk variables for the progression were CRP, LDH, RDW, ferritin, urea, and creatinine. With the help of laboratory parameters to predict mortality, we can define earlier the changes in immune insufficiency, coagulation problems, hepatic injury, and kidney injury.